Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 15, 2025
Ferroptosis
plays
a
critical
role
in
myocardial
ischemia-reperfusion
injury
(MIRI),
posing
significant
clinical
challenge.
Nanoenzymes
like
cerium
oxide
(CeO2)
hold
promise
for
mitigating
oxidative
damage
and
inhibiting
ferroptosis,
but
their
delivery
efficiency
biological
activity
require
optimization.
This
study
aims
to
develop
targeted
nanozyme
system
MIRI
treatment
by
integrating
CeO2
with
mesoporous
polydopamine
(mPDA)
dexrazoxane
(DXZ)
achieve
synergistic
therapeutic
effects.
A
biomineralization
technique
was
used
synthesize
nanoparticles
(2–3
nm)
within
mPDA,
forming
~
130
nm
composite
(Ce@mPDA).
Surface
modifications
cardiac
homing
peptide
(CHP)
triphenylphosphine
(TPP)
enabled
hierarchical
targeting
injured
myocardium
mitochondria.
DXZ-loaded
Ce@mPDA-C/P
(D/Ce@mPDA-C/P)
were
evaluated
vitro
mouse
model
effects
on
stress,
apoptosis,
inflammation,
function.
D/Ce@mPDA-C/P
exhibited
robust
ROS
scavenging,
sustained
DXZ
release,
efficient
mitochondrial
targeting.
The
significantly
reduced
upregulated
GPX4
expression,
inhibited
modulated
the
inflammatory
microenvironment.
Long-term
studies
demonstrated
reductions
fibrosis
improvements
function,
including
enhanced
fractional
shortening
ejection
fraction.
effectively
combines
antioxidant
properties
of
iron-chelating
DXZ,
providing
promising
strategy
MIRI.
approach
may
expand
use
advance
nanomedicine-based
interventions
repair.
Язык: Английский
Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment
Bioengineering,
Год журнала:
2025,
Номер
12(2), С. 205 - 205
Опубликована: Фев. 19, 2025
Myocardial
infarction
(MI)
is
a
cardiovascular
disease
(CVD)
with
high
morbidity
and
mortality
worldwide,
which
serious
threat
to
human
life
health.
Inflammatory
immune
responses
are
initiated
immediately
after
MI,
unbalanced
inflammation
post-MI
can
lead
cardiac
dysfunction,
scarring,
ventricular
remodeling,
emphasizing
the
critical
need
for
an
effective
inflammation-regulating
treatment.
With
development
of
novel
therapies,
drug
delivery
system
specific
inflammatory
cells
offers
significant
potential.
In
this
review,
we
introduce
fibroblasts
involved
in
MI
summarize
newly
developed
systems
related
use
injectable
hydrogels,
patches,
nanoparticles,
extracellular
vesicles
(EVs).
Finally,
highlight
recent
trends
cell-targeting
involving
different
strategies
that
facilitate
treatment
MI.
Язык: Английский
Roles of Autophagy, Mitophagy, and Mitochondria in Left Ventricular Remodeling after Myocardial Infarction
Xin Zhang,
Shuai Shao,
Qiuting Li
и другие.
Reviews in Cardiovascular Medicine,
Год журнала:
2025,
Номер
26(3)
Опубликована: Март 24, 2025
This
review
examines
the
mechanisms
of
left
ventricular
dysfunction,
focusing
on
interplay
between
remodeling,
autophagy,
and
mitochondrial
dysfunction
following
myocardial
infarction.
Left
directly
affects
heart's
pumping
efficiency
can
lead
to
severe
clinical
outcomes,
including
heart
failure.
After
infarction,
ventricle
may
suffer
from
weakened
contractility,
diastolic
cardiac
progressing
Thus,
this
article
discusses
pathophysiological
processes
involved
in
injury
repair
infarcted
non-infarcted
myocardia,
adaptive
changes,
specific
changes
systolic
functions.
Furthermore,
role
autophagy
maintaining
cellular
energy
homeostasis,
clearing
dysfunctional
mitochondria,
key
failure
is
addressed.
Finally,
therapeutic
strategies
targeting
enhancing
mitophagy,
providing
clinicians
researchers
with
latest
insights
future
research
directions.
Язык: Английский
Cardiac Macrophages Promote Polarization of Macrophages toward M2 Phenotype to Improve Myocardial Remodeling via NGAL after Myocardial Infarction
Cell Biochemistry and Biophysics,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Язык: Английский
Targeted delivery of Saikosaponin A and doxorubicin via hyaluronic acid-modified ZIF-8 nanoparticles for TNBC treatment: Inhibiting metastasis and reducing cardiotoxicity
Biomaterials Advances,
Год журнала:
2024,
Номер
167, С. 214114 - 214114
Опубликована: Ноя. 12, 2024
Язык: Английский
Immunomodulation with M2 macrophage–derived extracellular vesicles for enhanced titanium implant osseointegration under diabetic conditions
Materials Today Bio,
Год журнала:
2024,
Номер
30, С. 101385 - 101385
Опубликована: Дек. 6, 2024
M2
macrophage-derived
extracellular
vesicles
(M2-EVs)
demonstrate
the
capacity
to
reduce
pro-inflammatory
M1
macrophage
formation,
thereby
restoring
M1-M2
balance
and
promoting
immunoregulation.
However,
efficacy
of
M2-EVs
in
regulating
polarization
subsequently
enhancing
osseointegration
around
titanium
(Ti)
implants
patients
with
diabetes
mellitus
(DM)
remains
be
elucidated.
In
this
study,
Ti
were
coated
polydopamine
facilitate
adherence.
vitro
experiment
results
demonstrated
that
could
carry
miR-23a-3p,
inhibiting
NOD-like
receptor
protein3(NLRP3)
inflammasome
activation
reducing
levels
inflammatory
cytokines
such
as
IL-1β
by
targeting
NEK7.
This
improved
enhanced
mineralization
on
implant
surfaces.
The
vivo
diabetic
conditions,
nanocoated
significantly
promoted
high-quality
bone
deposition
implants.
current
provide
a
novel
perspective
for
simple
effective
decoration
implants;
clinically,
method
may
afford
osteoimmunomodulatory
effects
DM.
Язык: Английский