Renal-targeting bioinspired curcumin framework nanozyme for regulating inflammatory and oxidative stress homeostasis in acute kidney injury DOI Creative Commons

Xinyue Hou,

Mingyao Hu,

Jie Zhang

и другие.

Materials & Design, Год журнала: 2025, Номер unknown, С. 113900 - 113900

Опубликована: Апрель 1, 2025

Язык: Английский

Multifunctional integrated polyphenol-copper nanozymes for sepsis-induced acute liver injury via ameliorating endoplasmic reticulum stress and reprogramming inflammatory microenvironment DOI

D. Che,

Yao Xiao, Xiaoyong Zhang

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160293 - 160293

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Advanced 3D bioprinted liver models with human-induced hepatocytes for personalized toxicity screening DOI Creative Commons
Yue Ma,

Runbang He,

Bo Deng

и другие.

Journal of Tissue Engineering, Год журнала: 2025, Номер 16

Опубликована: Янв. 1, 2025

The development of advanced in vitro models for assessing liver toxicity and drug responses is crucial personalized medicine preclinical development. 3D bioprinting technology provides opportunities to create human that are suitable conducting high-throughput screening toxicity. In this study, we fabricated a humanized model using human-induced hepatocytes (hiHeps) derived from fibroblasts via rapid efficient reprogramming process. These hiHeps were then employed bioprinted with bioink materials closely mimic the natural extracellular matrix. constructed livers (h3DPLs) exhibited mature hepatocyte functions, including albumin expression, glycogen storage, uptake/release indocyanine green acetylated low-density lipoprotein. Notably, h3DPLs demonstrated increased sensitivity hepatotoxic agents such as acetaminophen (APAP), making them promising platform studying drug-induced injury. Furthermore, our accurately reflected impact rifampin, cytochrome P450 inducer, on CYP2E1 levels APAP hepatotoxicity. results highlight potential hiHep-based cost-effective high-performance alternative testing, paving way improved strategies therapeutic interventions.

Язык: Английский

Процитировано

0
An “all-in-one” therapeutic platform for programmed antibiosis, immunoregulation and neuroangiogenesis to accelerate diabetic wound healing DOI
Xue Yang, Lan Zhang, Jun Chen

и другие.

Biomaterials, Год журнала: 2025, Номер unknown, С. 123293 - 123293

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Renal-targeting bioinspired curcumin framework nanozyme for regulating inflammatory and oxidative stress homeostasis in acute kidney injury DOI Creative Commons

Xinyue Hou,

Mingyao Hu,

Jie Zhang

и другие.

Materials & Design, Год журнала: 2025, Номер unknown, С. 113900 - 113900

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0