Synthesis and biological evaluation of indole derivatives containing thiazolidine-2,4-dione as α-glucosidase inhibitors with antidiabetic activity

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 264, С. 115957 - 115957

Опубликована: Ноя. 24, 2023

Язык: Английский

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Thiazolidine-2,4-dione derivatives as potential α-glucosidase inhibitors: Synthesis, inhibitory activity, binding interaction and hypoglycemic activity

Bioorganic Chemistry, Год журнала: 2024, Номер 144, С. 107177 - 107177

Опубликована: Фев. 6, 2024

Язык: Английский

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Exploring the synthesis, molecular structure and biological activities of novel Bis-Schiff base derivatives: A combined theoretical and experimental approach

Journal of Molecular Structure, Год журнала: 2024, Номер 1306, С. 137828 - 137828

Опубликована: Фев. 17, 2024

Язык: Английский

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Synthesis, anti-α-glucosidase activity, inhibition interaction, and anti-diabetic activity of novel cryptolepine derivatives

Journal of Molecular Structure, Год журнала: 2024, Номер 1310, С. 138311 - 138311

Опубликована: Апрель 11, 2024

Язык: Английский

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Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α-Amylase and α-Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological Screening

ACS Omega, Год журнала: 2025, Номер 10(9), С. 9368 - 9380

Опубликована: Фев. 26, 2025

A series of chalcones containing a pyrrolidine moiety were synthesized to examine their in vitro α-amylase and α-glucosidase inhibitory activities, for the treatment Diabetes mellitus, which is one most dangerous rapidly increasing disorders today. Compound 3 exhibited an excellent dual effect with IC50 value 14.61 ± 0.12 μM against α-amylase, IC50: 25.38 2.09 α-glucosidase. The cytotoxic effects all compounds nonsmall lung cancer (A549) bronchial epithelial normal (BEAS-2B) cell lines also evaluated. 5 (IC50: 82.20 μM) compound 8 59.96 showed better activity than cisplatin A549 84.39 cells. Furthermore, these had no harmful on healthy BEAS-2B cells at determined values. Moreover, molecular docking dynamics simulation analysis revealed that stronger binding affinities toward compared positive control acarbose.

Язык: Английский

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Synthesis, activity, docking and dynamic simulation studies of novel pyrazolo-pyrano[2,3-d]-pyrimidine analogues as anti-diabetic agents

Journal of Molecular Structure, Год журнала: 2024, Номер 1305, С. 137720 - 137720

Опубликована: Фев. 7, 2024

Язык: Английский

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Lignan constituents with α-amylase and α-glucosidase inhibitory activities from the fruits of Viburnum urceolatum

Phytochemistry, Год журнала: 2023, Номер 216, С. 113895 - 113895

Опубликована: Окт. 11, 2023

Язык: Английский

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Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones

Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(10), С. 8461 - 8475

Опубликована: Окт. 19, 2023

Natural products are a boundless source for the development of pharmaceutical agents against wide range human diseases. Accordingly, naturally occurring aurones possess various biological benefits, such as anticancer, antioxidant, antimicrobial, antidiabetic, anti-inflammatory, antiviral and neuroprotective effects. In addition, studies have revealed that potential templates regulation diabetes mellitus its associated complications. Likewise, certain their analogues been found to be remarkable kinase inhibitors DARK2, PPAR-γ, PTPM1, AGE, α-amylase α-glucosidase, which represents promising approach treatment chronic metabolic disorders diabetes. Therefore, in our present study, we provide detailed account advances antidiabetic over past decade.

Язык: Английский

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Carbonylbis(hydrazine‐1‐carbothioamide) derivatives as a new class of α‐glucosidase inhibitors and their mechanistic insights via molecular docking and dynamic simulations

Archiv der Pharmazie, Год журнала: 2023, Номер 357(3)

Опубликована: Дек. 26, 2023

Abstract In the past, efforts have been made to find a cure for diabetes, mainly evaluating new classes of compounds explore their potency. this study, we present synthesis and evaluation carbonylbis(hydrazine‐1‐carbothioamide) derivatives as potential α‐glucosidase inhibitors, employing both in vivo silico investigations. The vitro experiments revealed that all tested were significantly potent inhibition, with lead compound 3a displaying approximately 80 times higher activity than acarbose. To delve deeper, induced fit docking, pharmacokinetics, molecular dynamics studies conducted. Significantly, exhibited docking score −7.87 kcal/mol, surpassing acarbose, which had −6.59 kcal/mol. ADMET indicated most synthesized properties conducive drug development. Molecular analysis demonstrated that, when ligand was coupled target 3TOP, Cα‐RMSD backbone RMSD values below 2.4 Å “Lig_fit_Prot” 2.7 observed. QSAR demonstrates “fOC8A” descriptor positively correlates inhibition activity, while “lipoplus_AbSA” contributes “notringC_notringO_8B” negatively activity.

Язык: Английский

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1,2,3-Triazole based xanthene and acridine linkers as potential α-glucosidase and α-amylase inhibitors: design, green synthesis, kinetics, and in silico studies

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 141196 - 141196

Опубликована: Дек. 1, 2024

Язык: Английский

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