Thienopyrimidine: A promising scaffold in the development of kinase inhibitors with anticancer activities
Bioorganic & Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown, С. 118109 - 118109
Опубликована: Фев. 1, 2025
Язык: Английский
Potential bidirectional regulatory effects of botanical drug metabolites on tumors and cardiovascular diseases based on the PI3K/Akt/mTOR pathway
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 24, 2025
Pharmacological
interventions
targeting
the
phosphatidylinositol-3-kinase/protein
kinase
B/mammalian
target
of
rapamycin
(PI3K/Akt/mTOR)
signaling
pathway
are
predominantly
employed
as
anticancer
therapies,
yet
they
frequently
associated
with
significant
cardiac
toxicity.
Additionally,
PI3K/Akt/mTOR
plays
a
crucial
role
in
treatment
cardiovascular
diseases,
highlighting
its
dual
significance
both
oncology
and
cardiology.
Therefore,
has
become
an
ideal
for
studying
cardioprotection,
effects,
their
Botanical
drugs
have
emerged
source
developing
therapeutic
agents
cardioprotective
often
exhibiting
bidirectional
protective
properties.
Consequently,
this
study
investigates
regulatory
influence
botanical
drug
metabolites
cardiology
via
pathway.
The
research
indicated
that
critical
pathogenesis
tumors
diseases.
Ruscogenin,
Sulforaphane,
Naringenin,
Kaempferol,
Poncirin,
Puerarin
can
improve
cancer
by
inhibiting
phosphorylation
levels
within
cascade.
Moreover,
also
provide
effects
injury
conditions
activating
dynamics
key
components
pathway,
particularly
Akt,
along
functional
implications
different
sites,
may
offer
new
strategies
insights
mitigation
cardiotoxicity
therapies.
Язык: Английский
Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway
Phytomedicine,
Год журнала:
2025,
Номер
141, С. 156701 - 156701
Опубликована: Март 29, 2025
Язык: Английский
Novel Strategies in Breast Cancer Management: from Treatment to Long-term Remission
Critical Reviews in Oncology/Hematology,
Год журнала:
2025,
Номер
unknown, С. 104715 - 104715
Опубликована: Апрель 1, 2025
Язык: Английский
Expanding the Horizon of Pteridine Chemistry: Optimized Synthesis by the Isay Reaction, and Molecular-Docking Studies
Synlett,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Abstract
The
Isay
reaction
was
used
to
synthesize
novel
disubstituted
pteridine
derivatives.
scaffold
synthesized
by
reacting
a
mercaptopyrimidine
derivative
with
substituted
diketone,
followed
phenylurea
derivative.
Standard
physicochemical
and
spectroscopic
techniques,
such
as
FTIR,
mass
spectrometry,
1H
NMR,
D2O
exchange,
HPLC
confirmed
the
structures
purities
of
compounds.
Various
key
substituents
on
were
incorporated
explore
their
effects
chemical
biological
properties
products.
Molecular-docking
studies
against
proteins
PI3K
(PDB
ID:
4L23)
mTOR
4JT6),
showed
promising
interactions
that
supported
potential
activity
These
findings
provide
strong
basis
for
further
optimization
evaluation,
particularly
in
development
anticancer
agents.
Язык: Английский
The antibreast cancer therapeutic potential of quinazoline hybrids–Part I
Future Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown, С. 1 - 15
Опубликована: Апрель 30, 2025
Breast
cancer
is
the
most
commonly
diagnosed
in
women
and
leading
cause
of
cancer-related
mortality
among
female
patients
across
world.
Chemotherapy
a
critical
means
for
breast
therapy,
administration
chemotherapy
could
reduce
risk
recurrence
by
approximately
one-third
early
cancer.
However,
multidrug
resistance
represents
principal
obstacle
to
effective
chemotherapeutic
interventions
against
an
increasing
clinical
challenge,
creating
urgent
demand
explore
innovative
chemotherapeutics
combat
this
formidable
disease.
Quinazoline
hybrids
with
structural
mechanistic
diversity
exhibit
excellent
activity
cancers
including
drug-resistant
forms
have
potential
side
effects
caused
corresponding
pharmacophores.
Notably,
lapatinib,
quinazoline-furan-sulfone
hybrid,
has
already
been
launched
therapy.
Thus,
quinazoline
represent
fertile
source
development
novel
deployment
control
eradication
This
review
emphasizes
current
scenario
antibreast
therapeutic
focuses
on
structure-activity
relationships
(SARs)
modes
action,
developed
from
2020
onwards,
facilitate
rational
discovery
more
candidates.
[Figure:
see
text]This
landscape
potential,
delves
into
mechanisms
action
aiming
less
toxic
Язык: Английский
Gene selection and cancer classification using interaction-based feature clustering and improved-binary Bat algorithm
Computers in Biology and Medicine,
Год журнала:
2024,
Номер
181, С. 109071 - 109071
Опубликована: Авг. 27, 2024
Язык: Английский
Comprehensive single-cell and bulk transcriptomic analyses to develop an NK cell-derived gene signature for prognostic assessment and precision medicine in breast cancer
Qianshan Hou,
Chunzhen Li,
Y.M. Chong
и другие.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 23, 2024
Background
Natural
killer
(NK)
cells
play
crucial
roles
in
mediating
anti-cancer
activity
breast
cancer
(BRCA).
However,
the
potential
of
NK
cell-related
molecules
predicting
BRCA
outcomes
and
guiding
personalized
therapy
remains
largely
unexplored.
This
study
focused
on
developing
a
prognostic
therapeutic
prediction
model
for
by
incorporating
genes.
Methods
The
data
analyzed
primarily
originated
from
TCGA
GEO
databases.
role
was
evaluated,
marker
genes
were
identified
via
single-cell
analysis.
Module
closely
associated
with
immunotherapy
resistance
bulk
transcriptome-based
weighted
correlation
network
analysis
(WGCNA).
Following
taking
intersection
LASSO
regression,
NK-related
(NKRGs)
relevant
to
prognosis
screened,
signature
subsequently
constructed.
Analyses
further
expanded
clinicopathological
relevance,
GSEA,
tumor
microenvironment
(TME)
analysis,
immune
function,
responsiveness,
chemotherapeutics.
Key
NKRGs
screened
machine
learning
validated
spatial
transcriptomics
(ST)
immunohistochemistry
(IHC).
Results
Tumor-infiltrating
are
favorable
factor
BRCA.
By
combining
scRNA-seq
transcriptomic
analyses,
we
7
(CCL5,
EFHD2,
KLRB1,
C1S,
SOCS3,
IRF1,
CCND2)
developed
an
risk
scoring
(NKRS)
system.
reliability
NKRS
verified
through
survival
clinical
relevance
analyses
across
multiple
cohorts.
also
demonstrated
robust
predictive
power
various
aspects,
including
TME
landscape,
functions,
responses,
chemotherapeutic
sensitivity.
Additionally,
KLRB1
CCND2
emerged
as
key
external
validation,
their
expression
confirmed
specimens
ST
IHC.
Conclusions
We
novel
gene
that
has
proven
valuable
evaluating
treatment
response
BRCA,
expecting
advance
precision
medicine
Язык: Английский
Discovery of novel pyrrolo[2,3-d]pyrimidine derivatives as anticancer agents: virtual screening and molecular dynamic studies
SAR and QSAR in environmental research,
Год журнала:
2024,
Номер
unknown, С. 1 - 33
Опубликована: Ноя. 28, 2024
CDK/Cyclins
are
dysregulated
in
several
human
cancers.
Recent
studies
showed
inhibition
of
CDK4/6
was
responsible
for
controlling
cell
cycle
progression
and
cancer
growth.
In
the
present
study,
atom-based
field-based
3D-QSAR,
virtual
screening,
molecular
docking
dynamics
were
done
development
novel
pyrrolo[2,3-d]pyrimidine
(P2P)
derivatives
as
anticancer
agents.
The
developed
models
good
Язык: Английский