Molecular Basis for the P450-Catalyzed sp³ C–N Glycosidic Bond Formation in Staurosporine Biosynthesis

ACS Catalysis, Год журнала: 2024, Номер 14(19), С. 14274 - 14284

Опубликована: Сен. 12, 2024

Язык: Английский

Keto-Oxygen on Graphitic Surface with Downshifted p-Band Center Achieves Efficient Metal-Free Transfer Hydrogenation of Nitroarenes

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

The critical challenge in utilizing carbon-based nanomaterials is identifying the active site. Herein, we demonstrate keto-oxygen on graphitic surface as sites for catalytic transfer hydrogenation (CTH) and present an efficient nanocrystalline diamond (ND)-derived catalyst metal-free CTH of nitroarenes to imine with 99.9% nitrobenzene conversion exclusive selectivity (99.9%). By selectively deconstructing or eliminating carbonyl groups, graphite-conjugated group confirmed catalytically Moreover, kinetic studies display lower activation barrier benzylalcohol than that (88.8 vs 119.1 kJ mol-1, respectively), indicating alcohol dehydrogenation occurs prior nitrobenzene. Density functional theory calculations reveal downshifted p-band center sp2 hybrid C affords moderate adsorption benzaldehyde intermediates, which accelerates formation H following step responsible high activity.

Язык: Английский

Progress in Enzyme-Catalyzed C(sp³)–H Amination

ACS Catalysis, Год журнала: 2024, Номер 14(18), С. 14139 - 14160

Опубликована: Сен. 11, 2024

Язык: Английский