Abstract
Enzyme
inhibition
is
a
frequently
employed
technique
for
regulating
enzyme
activity
in
several
biological
systems
that
are
physiologically
significant.
In
this
study,
it
was
evaluated
the
effectiveness
of
six
specific
quinolone
medicines,
namely
lomefloxacin,
nalidixic
acid,
gatifloxacin,
norfloxacin,
sparfloxacin
and
nitrofurantoin,
inhibiting
two
human
isoforms
carbonic
anhydrase
(hCA)
play
role
different
physiological
pathological
circumstances.
order
to
achieve
objective,
both
vitro
silico
investigations
were
conducted
get
deeper
understanding
potential
binding
interactions
affinities
hCA
I
II
isoforms.
The
kinetic
inhibitory
effects
(K
i
s)
ranged
from
1.31
13.07
μM,
comparison
reference
medication
acetazolamide
(AAZ,
K
0.12
μM).
addition,
effectively
suppressed
by
these
drugs,
with
s
ranging
1.42
11.93
compared
AAZ
0.098
Significant
between
medicines
hCAs
indicated
their
support
therapeutic
targets
against
diseases.
Furthermore,
findings
acquired
will
contribute
enhancement
dose
regimens
medications
prevention
unforeseen
drug‐drug
when
administered
concurrently
other
substances.
New Journal of Chemistry,
Год журнала:
2024,
Номер
48(24), С. 10979 - 10989
Опубликована: Янв. 1, 2024
Investigating
innovative
frameworks
for
addressing
Alzheimer's
disease
is
a
challenging
goal.
In
this
specific
scenario,
selection
of
asymmetric
biscarbothioamide
derivatives
(3a–l)
with
different
substitutions
has
been
carefully
formulated
and
successfully
synthesized.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
38(4)
Опубликована: Апрель 1, 2024
Abstract
Doxorubicin
(DOX)
is
widely
used
in
cancer
treatment
but
the
dose‐related
toxicity
of
DOX
on
organs
including
liver
limit
its
use.
Therefore,
there
great
interest
combining
with
natural
compounds
antioxidant
properties
to
reduce
and
increase
drug
efficacy.
Esculetin
a
coumarin
derivative
biological
encompassing
anti‐inflammatory
activities.
In
light
these
properties,
this
study
was
meticulously
crafted
investigate
potential
esculetin
preventing
doxorubicin
(DOX)‐induced
hepatotoxicity
Sprague‐Dawley
rats.
The
rats
were
divided
into
total
six
groups:
control
group,
group
(administered
at
cumulative
dose
5
mg/kg
intraperitoneally
every
other
day
for
2
weeks),
E50
50
day),
E100
100
day)
combined
groups
(DOX
+
E100)
which
administered
together
DOX.
treatments,
both
alone
combination
E50,
manifested
reduction
catalase
(CAT
mRNA)
levels
comparison
group.
Notably,
enzymatic
activities
superoxide
dismutase
(SOD),
CAT,
glutathione
peroxidase
(GPx)
witnessed
significant
decreases
treated
Moreover,
induced
statistically
elevation
malondialdehyde
(MDA)
levels,
coupled
concurrent
decrease
(GSH)
levels.
Additionally,
molecular
docking
studies
conducted.
However,
further
are
needed
confirm
hepatoprotective
precisely
elucidate
mechanisms
action.
