Palladium-Catalyzed Asymmetric Allylic Alkylation of Azlactones: An Efficient Access to Unsaturated Trifluoromethylated α-Amino Acid Derivatives Possessing α-Quaternary Stereogenic Centers

Synthesis, Год журнала: 2024, Номер 56(20), С. 3220 - 3232

Опубликована: Июль 4, 2024

Abstract A new strategy for the asymmetric allylic alkylation of azlactones with α-(trifluoromethyl)allyl acetates catalyzed by Pd(OAc)2/(R)-BINAP is designed and developed, providing access to unsaturated α-quaternary α-amino acid derivatives bearing a trifluoromethyl group contiguous quaternary tertiary stereogenic centers. The products are obtained in good yields exclusive regioselectivity excellent stereoselective control under relatively mild reaction conditions. scale-up experiment shows no loss reactivity or stereoselectivity. synthetic utility current demonstrated through transformations representative product afford several potentially bioactive species.

Язык: Английский

2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat

Bioorganic Chemistry, Год журнала: 2024, Номер 154, С. 108050 - 108050

Опубликована: Дек. 13, 2024

Язык: Английский