Clove Essential Oil as a Source of Antitumoral Compounds Capable of Crossing the Blood–Brain Barrier: A Focus on the Effects of β-Caryophyllene and Eugenol in a Glioblastoma Cell Line DOI Open Access
Renato Spigarelli, Enzo Spisni, Mariana Magalhães

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 238 - 238

Опубликована: Дек. 30, 2024

This study aimed to investigate β-Caryophyllene (BCA) pharmacokinetics as well the potential antitumor activity and mechanism of action BCA eugenol (EU), alone or in combination, U87 glioblastoma (GB) cells. The pharmacokinetic was studied by evaluating its concentration profiles rat blood cerebrospinal fluid after oral intravenous administration. EU mechanisms were assessed comparing their effects GB cells non-tumoral HMC3 Cell death, cell cycle regulation mitochondrial membrane (MMP) evaluated using flow cytometry. mRNA levels target genes qPCR. Secreted cytokines measured Luminex®. BCA, EU, permeates brain. affected viability proliferation (up 50%, p < 0.001) but not showed a synergistic effect. induced G0/G1 arrest, increasing apoptosis/necrosis. downregulation mRNAs encoding for key proteins involved angiogenesis (VEGFA decreased op 60%, 0.01), progression, anti-inflammatory (IL-4 significantly decreased, 0.001). demonstrated strong multitarget Our results provide rationale further evaluation possible therapeutic molecules management.

Язык: Английский

Molecular principles underlying aggressive cancers DOI Creative Commons
Ruth Nussinov, Bengi Ruken Yavuz, Hyunbum Jang

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 16, 2025

Язык: Английский

Процитировано

3
Comparisons of clinical characteristics, treatments, and outcomes among different pathological subtypes of chondrosarcoma in the spine DOI
Jian Sun, Zhipeng Wu,

Jian Jiao

и другие.

Journal of Neuro-Oncology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 14, 2024

Язык: Английский

Процитировано

0
Clove Essential Oil as a Source of Antitumoral Compounds Capable of Crossing the Blood–Brain Barrier: A Focus on the Effects of β-Caryophyllene and Eugenol in a Glioblastoma Cell Line DOI Open Access
Renato Spigarelli, Enzo Spisni, Mariana Magalhães

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 238 - 238

Опубликована: Дек. 30, 2024

This study aimed to investigate β-Caryophyllene (BCA) pharmacokinetics as well the potential antitumor activity and mechanism of action BCA eugenol (EU), alone or in combination, U87 glioblastoma (GB) cells. The pharmacokinetic was studied by evaluating its concentration profiles rat blood cerebrospinal fluid after oral intravenous administration. EU mechanisms were assessed comparing their effects GB cells non-tumoral HMC3 Cell death, cell cycle regulation mitochondrial membrane (MMP) evaluated using flow cytometry. mRNA levels target genes qPCR. Secreted cytokines measured Luminex®. BCA, EU, permeates brain. affected viability proliferation (up 50%, p < 0.001) but not showed a synergistic effect. induced G0/G1 arrest, increasing apoptosis/necrosis. downregulation mRNAs encoding for key proteins involved angiogenesis (VEGFA decreased op 60%, 0.01), progression, anti-inflammatory (IL-4 significantly decreased, 0.001). demonstrated strong multitarget Our results provide rationale further evaluation possible therapeutic molecules management.

Язык: Английский

Процитировано

0