Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

The enantioselective formal (3 + 2) cyclization and sequential reaction of 2-malononitrile-substituted oxindoles with benzaldehydes ortho-aminobenzaldehydes were achieved by chiral N,N′-dioxide/metal complex Lewis acid catalysts. This protocol supplies facile efficient access to highly functionalized dihydrofuran- azepine-based spirooxindoles. Based on the control experiments deuterium labeling studies, interconversion diastereomeric intermediates under conditions reversible 1,5-H transfer step disclosed.

Язык: Английский