Current Molecular Medicine,
Год журнала:
2020,
Номер
20(7), С. 516 - 526
Опубликована: Янв. 29, 2020
Circular
RNAs,
a
group
of
endogenous
non-coding
are
characterized
by
covalently
closed
cyclic
structures
with
no
poly-adenylated
tails.
It
has
been
recently
recommended
that
cirRNAs
have
an
essential
role
in
regulating
genes
expression
functioning
as
translational
regulator,
RNA
binding
protein
sponge
and
microRNA
sponge.
Due
to
their
close
relation
the
progression
various
diseases
such
diabetes,
circRNAs
become
research
hotspot.
A
number
(i.e.,
circRNA_0054633,
circHIPK3,
circANKRD36,
circRNA11783-2)
shown
be
associated
initiation
diabetes.
Based
on
reports,
tissue,
some
expressed
developmental
stage-specific
manner.
In
this
study,
we
reviewed
circular
RNAs
involved
pathogenesis
diagnosis
diabetes
prognostic
roles.
Abstract
The
tumour
microenvironment
(TME)
constitutes
the
area
surrounding
during
its
development
and
has
been
demonstrated
to
play
roles
in
cancer-related
diseases
through
crosstalk
with
cells.
Circular
RNAs
(circRNAs)
are
a
subpopulation
of
endogenous
noncoding
(ncRNAs)
that
ubiquitously
expressed
eukaryotes
have
multiple
biological
functions
regulation
cancer
onset
progression.
An
increasing
number
studies
shown
circRNAs
participate
multifaceted
TME.
However,
details
on
mechanisms
involved
remained
elusive
until
now.
In
this
review,
we
analyse
effects
TME
from
various
perspectives,
including
immune
surveillance,
angiogenesis,
hypoxia,
matrix
remodelling,
exo-circRNAs
chemoradiation
resistance.
Currently,
enormous
potential
for
circRNA
use
targeted
therapy
as
noninvasive
biomarkers
drawn
our
attention.
We
emphasize
prospect
targeting
an
essential
strategy
regulate
TME,
overcome
resistance
improve
therapeutic
outcomes.
Cardiovascular Research,
Год журнала:
2019,
Номер
115(12), С. 1732 - 1756
Опубликована: Авг. 5, 2019
Atherosclerosis
underlies
the
predominant
number
of
cardiovascular
diseases
and
remains
a
leading
cause
morbidity
mortality
worldwide.
The
development,
progression
formation
clinically
relevant
atherosclerotic
plaques
involves
interaction
distinct
over-lapping
mechanisms
which
dictate
roles
actions
multiple
resident
recruited
cell
types
including
endothelial
cells,
vascular
smooth
muscle
monocyte/macrophages.
discovery
non-coding
RNAs
(ncRNAs)
microRNAs,
long
RNAs,
circular
their
identification
as
key
mechanistic
regulators
mRNA
protein
expression
has
piqued
interest
in
potential
contribution
to
atherosclerosis.
Accruing
evidence
revealed
ncRNAs
regulate
pivotal
cellular
molecular
processes
during
all
stages
atherosclerosis
invasion,
growth,
survival;
uptake
efflux
lipids,
release
pro-
anti-inflammatory
intermediaries,
proteolytic
balance.
profile
within
lesions
circulation
have
been
determined
with
aim
identifying
individual
or
clusters
may
be
viable
therapeutic
targets
alongside
deployment
biomarkers
plaque
progression.
Consequently,
numerous
vivo
studies
convened
determine
effects
moderating
function
select
well-characterized
animal
models
Together,
clinicopathological
findings
elucidated
multifaceted
frequently
divergent
impose
both
directly
indirectly
on
From
these
findings'
novel
strategies
discovered
pave
way
for
further
translational
possibly
taken
forward
clinical
application.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2019,
Номер
38(1)
Опубликована: Фев. 8, 2019
Angiogenesis
plays
a
critical
role
in
the
progression
of
glioma.
Previous
studies
have
indicated
that
RNA-binding
proteins
(RBPs)
interact
with
RNAs
and
participate
regulation
malignant
behaviors
tumors.
As
type
endogenous
non-coding
RNAs,
circular
(circRNAs)
are
abnormally
expressed
various
cancers
involved
diverse
tumorigeneses
including
angiogenesis.The
expression
levels
FUS,
circ_002136,
miR-138-5p,
SOX13,
SPON2
were
determined
using
quantitative
real-time
PCR
(qRT-PCR)
western
blot.
Transient
cell
transfection
was
performed
Lipofectamine
3000
reagent.
The
protein
immunoprecipitation
(RNA-IP)
RNA
pull-down
assays
used
to
detect
interaction
between
FUS
circ_002136.
dual-luciferase
reporter
assay
system
binding
sites
circ_002136
miR-138-5p
SOX13.
chromatin
(ChIP)
examine
interactions
transcription
factor
SOX13
its
target
.We
demonstrated
down-regulation
or
dramatically
inhibited
viability,
migration
tube
formation
U87
glioma-exposed
endothelial
cells
(GECs).
MiR-138-5p
down-regulated
GECs
functionally
targeted
an
RNA-induced
silencing
complex
(RISC).
Inhibition
combined
restoration
robustly
reduced
angiogenesis
GECs.
gene
overexpressed
proved
be
miR-138-5p-mediated
gliomas.
In
addition,
we
found
directly
associated
activated
promoter,
thereby
up-regulating
at
transcriptional
level.
Knockdown
suppressed
More
important,
promoter
increased
expression,
forming
feedback
loop.Our
data
suggests
loop
FUS/circ_002136/miR-138-5p/SOX13
played
crucial
This
also
provides
potential
alternative
strategy
for
glioma
therapy.
Theranostics,
Год журнала:
2021,
Номер
11(8), С. 3996 - 4010
Опубликована: Янв. 1, 2021
Exosomes
are
nanosized
lipid
vesicles
originating
from
the
endosomal
system
that
carry
many
macromolecules
their
parental
cells
and
play
important
roles
in
intercellular
communication.
The
functions
underlying
mechanisms
of
exosomes
atherosclerosis
have
recently
been
intensively
studied.
In
this
review,
we
briefly
introduce
exosome
biology
then
focus
on
advances
atherosclerosis,
specifically
exosomal
changes
associated
with
cellular
origins
potential
functional
cargos,
detailed
impacts
recipient
cells.
We
also
discuss
as
biomarkers
drug
carriers
for
managing
atherosclerosis.
Aging,
Год журнала:
2018,
Номер
10(9), С. 2266 - 2283
Опубликована: Сен. 6, 2018
Atherosclerosis
is
a
chronic
and
multifactorial
inflammatory
disease
closely
associated
with
cardiovascular
cerebrovascular
diseases.
circRNAs
can
act
as
competing
endogenous
RNAs
to
mRNAs
function
in
various
However,
there
little
known
about
the
of
atherosclerosis.
In
this
study,
three
rabbits
case
group
were
fed
high-fat
diet
induce
atherosclerosis
another
normal
diet.
To
explore
biological
functions
atherosclerosis,
we
analyzed
circRNA,
miRNA
mRNA
expression
profiles
using
RNA-seq.
Many
miRNAs,
identified
significantly
changed
We
next
predicted
miRNA-target
interactions
miRanda
tool
constructed
differentially
expressed
circRNA-miRNA-mRNA
triple
network.
A
gene
ontology
enrichment
analysis
showed
that
genes
network
involved
cell
adhesion,
activation
immune
response.
Furthermore,
generated
dysregulated
circRNA-related
ceRNAs
found
seven
(ocu-cirR-novel-18038,
-18298,
-15993,
-17934,
-17879,
-18036
-14389)
related
these
also
functioned
These
results
show
crosstalk
between
their
might
play
crucial
roles
development