Edible Mushrooms for Sustainable and Healthy Human Food: Nutritional and Medicinal Attributes

Sustainability, Год журнала: 2022, Номер 14(9), С. 4941 - 4941

Опубликована: Апрель 20, 2022

Global food production faces many challenges, including climate change, a water crisis, land degradation, and desertification. These challenges require research into non-traditional sources of human foods. Edible mushrooms are considered an important next-generation healthy source. rich in proteins, dietary fiber, vitamins, minerals, other bioactive components (alkaloids, lactones, polysaccharides, polyphenolic compounds, sesquiterpenes, sterols, terpenoids). Several ingredients can be extracted from edible incorporated health-promoting supplements. It has been suggested that several diseases treated with extracts mushrooms, as these have biological effects anticancer, antidiabetic, antiviral, antioxidant, hepatoprotective, immune-potentiating, hypo-cholesterolemic influences. The current study focuses on sustainable approaches for handling their secondary metabolites, biofortification. Comparisons between poisonous well the common species different ingredients, crucial. Nutritional values health benefits biomedical applications, also emphasized. Further is needed to explore economic sustainability medicinal mushroom compound potential applications against emerging such COVID-19. New nano-biofortification supply essential nutrients and/or increase ingredients.

Язык: Английский

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Mushrooms as future generation healthy foods

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Дек. 6, 2022

The potential of edible mushrooms as an unexploited treasure trove, although rarely included in known food guidelines, is highlighted. Their role shielding people against the side effects unhealthy stylish diet reviewed. Mushrooms complement human with various bioactive molecules not identified or deficient foodstuffs plant and animal sources, being considered a functional for prevention several diseases. have been widely used medicinal products more than 2,000 years, but globally field use wild has untapped. There broad range which remain poorly even unreported valuable pool sources compounds biopharma utilization new dietary supplements. Some unique elements their preventative healthcare are emphasized, through positive impact on immune system. antiviral, anti-inflammatory, anti-neoplastic, other health concerns discussed. incorporate top non-digestible oligosaccharides, ergothioneine, humans unable to synthesize, later antioxidant, cytoprotective, anti-inflammatory element, therapeutic potential, approved by world agencies. prebiotic activity beneficially affects gut homeostasis performance balance microbiota enhanced. Several recent studies neurological contribution growth nerve brain cells mentioned. Indeed, foods' nutraceuticals presently regarded next-generation foods, supporting wellness, promising prophylactic agents.

Язык: Английский

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Quality evaluation of value-added nutritious biscuit with high antidiabetic properties from blends of wheat flour and oyster mushroom

Food Chemistry Advances, Год журнала: 2023, Номер 3, С. 100375 - 100375

Опубликована: Июль 5, 2023

The aim of this study was to produce biscuit from blend mushroom flour and wheat flour. composite at 0, 10, 20, 30 40% level inclusion. analyzed for proximate composition, physical properties, mineral content, antioxidant carbohydrate inhibitory enzyme activities, glycemic index, trend in blood glucose concentration, microbiological sensory evaluation. Result the analysis showed that as proportion increased protein con also increased. content ranged 10.36 17.92 % while ash 0.63 3.31%. properties spread ratio with increase incorporation result revealed sodium calcium activities inhibited key digestive enzymes such (α- amylase α- glucosidase). index possessed low load. concentration rats fed increasing has a positive effect lower postprandial response WFMRB4 being lowest. microbial count 2 × 102 5.0 Cfu/g bacteria 1.0×102 3.0 cfu/g mould count. E coli not detected biscuit. Sensory evaluation biscuits were rated above average. can therefore be used manage diabetes mellitus overcome protein-energy deficiency.

Язык: Английский

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Understanding of Alzheimer's Disease Pathophysiology for Therapeutic Implications of Natural Products as Neuroprotective Agents

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102680 - 102680

Опубликована: Фев. 1, 2025

Язык: Английский

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Therapeutic Potential of Vital Transcription Factors in Alzheimer’s and Parkinson’s Disease With Particular Emphasis on Transcription Factor EB Mediated Autophagy

Frontiers in Neuroscience, Год журнала: 2021, Номер 15

Опубликована: Дек. 14, 2021

Autophagy is an important cellular self-digestion and recycling pathway that helps in maintaining homeostasis. Dysregulation at various steps of the autophagic endolysosomal has been reported several neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s (PD), Huntington (HD) cited a critically feature for central nervous system (CNS) proteostasis. Recently, another molecular target, namely transcription factor EB (TFEB) explored globally to treat disorders. This TFEB, key regulator autophagy lysosomal biogenesis pathway. Multiple research studies suggested therapeutic potential by targeting TFEB human diseases involving autophagy-lysosomal dysfunction, especially A common observation all their poor efficacy clearing recycle toxic aggregated proteins damaged organelles due impairment dysfunction characterized accumulation protein aggregates leads progressive loss structural integrity/functionality neurons may even result neuronal death. In recent years biogenesis, received considerable attention. It emerged target numerous like AD PD. neurobiology animal models, found ameliorate neurotoxicity rescue neurodegeneration. Since master transcriptional plays crucial role defining activation. Studies have done understand mechanisms which yield insights into how might be targeted used strategy develop treatment process with extensive application this review, we explore different factor-based therapy some natural compounds PD special emphasis on TFEB.

Язык: Английский

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DHA and Its Elaborated Modulation of Antioxidant Defenses of the Brain: Implications in Aging and AD Neurodegeneration

Antioxidants, Год журнала: 2021, Номер 10(6), С. 907 - 907

Опубликована: Июнь 3, 2021

DHA (docosahexaenoic acid) is perhaps the most pleiotropic molecule in nerve cell biology. This long-chain highly unsaturated fatty acid has evolved to accomplish essential functions ranging from structural components allowing fast events membrane physiology regulation of neurogenesis and synaptic function. Strikingly, plethora effects take place within hostile pro-oxidant environment brain parenchyma, which might suggest a molecular suicide. In order circumvent this paradox, different strategies have during evolution cells preserve minimize deleterious its oxidation. context, emerged as member “indirect antioxidants” family, redox are not due direct interactions with reactive species, but modulation gene expression thioredoxin glutathione antioxidant systems related pathways. Weakening or deregulation these self-protecting defenses orchestrated by associated normal aging also, more worryingly, development neurodegenerative diseases. present review, we elaborate on brain, including role indirect antioxidant, selenium connection for proper function their changes Alzheimer’s disease.

Язык: Английский

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A Comprehensive Review on Phytochemical Profiling in Mushrooms: Occurrence, Biological Activities, Applications and Future Prospective

Food Reviews International, Год журнала: 2023, Номер 40(3), С. 924 - 951

Опубликована: Апрель 17, 2023

Mushrooms have been an acclaimed food for their unique flavor and medicinal properties since ancient times. Modern research shows that mushrooms are rich in various nutrients biologically active substances. In recent years, researchers become increasingly interested because they contain important secondary metabolites, such as phenolic compounds with significant bioactive properties. This review introduces the nutritional components metabolites mushrooms, focusing on functions potential applications of mushroom polyphenols. Finally, current challenges future trends polyphenols briefly discussed. aspect value, high protein insoluble fiber, while low fat sodium, making them a low-energy, healthy food. large amount beneficial substances health, including compounds, well tocopherols, terpenoids, phytosterols. Mushroom antioxidant, anti-inflammatory, anti-cancer, anti-tyrosine, antihyperglycemic, other biological activities to human health medical applications, especially degenerative disease cancer treatments. However, based development commercial still face many issues need be addressed by researchers.

Язык: Английский

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Recent advances in Mushroom-mediated nanoparticles: A critical review of mushroom biology, nanoparticles synthesis, types, characteristics and applications

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 96, С. 105695 - 105695

Опубликована: Апрель 21, 2024

Язык: Английский

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Edible Mushroom Bioactive Compounds and Neurogenic Diseases

Reference series in phytochemistry, Год журнала: 2025, Номер unknown, С. 1 - 37

Опубликована: Янв. 1, 2025

Язык: Английский

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Pharmacological evaluation and phytochemical profiling of butanol extract of L. edodes with in- silico virtual screening

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 8, 2024

Abstract L. edodes ( ) is the most consumed mushroom in world and has been well known for its therapeutic potential as an edible medicinal candidate, it contains dietary fibers, vitamins, proteins, minerals, carbohydrates. In current study butanolic extract of was used to form semisolid butanol extract. The aimed explore biometabolites that might have biological activities n -butanol using FT-IR GC–MS LC–MS. synergistic properties bioactive compounds were futher assessed by performing different assays such antioxidant, anti-inflammatory antidiabetic. FTIR spectra showed functional groups including amide N–H group, Alkane (C-H stretching), (C = C stretching) at spectrum peaks range 500 cm −1 5000 respectively. profiling depicted 34 potent biomolecules among those dimethyl; Morphine, 2TMS derivative; Benzoic acid, methyl ester 1-(2-methoxy-1-methylethoxy)-2-propanol spotted highest range. Results indicate n- a maximum 91.4% 300 mg/mL. Antioxidant activity observed measuring free radical scavenging which 64.6% optimized concentration along with good antidiabetic activity. In-silico executed biopotential active ingredient morphine proved best docking score (− 7.0 kJ/mol) against aldose reductase. in-silico drug design analysis performed on detected through be target sulfatase-2 treat ruminated arthritis. Morphine binds more strongly 7.9 than other constituents indicated. QSAR ADMET shown candidates molecules cure multiple ailments. As mushrooms high bioactivity, they can diseases develop antibacterial drugs based situation resistance going increase due misuse antibiotics so new noval are needed overcome situation.

Язык: Английский

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