Pharmaceuticals,
Год журнала:
2023,
Номер
16(2), С. 151 - 151
Опубликована: Янв. 19, 2023
Dementia,
most
often
associated
with
neurodegenerative
diseases,
affects
millions
of
people
worldwide,
predominantly
the
elderly.
Unfortunately,
no
treatment
is
still
available.
Therefore,
there
an
urgent
need
to
address
this
situation.
This
review
presents
state
art
drug
discovery
and
developments
in
targeting
dementia.
Several
approaches
are
discussed,
such
as
repurposing,
use
small
molecules,
phosphodiesterase
inhibitors.
Furthermore,
also
provides
insights
into
clinical
trials
these
molecules.
Emphasis
has
been
placed
on
molecules
multi-target-directed
ligands,
well
disease-modifying
therapies.
Finally,
attention
drawn
possibilities
applications
nanotechnology
managing
Nanomaterials,
Год журнала:
2022,
Номер
12(13), С. 2140 - 2140
Опубликована: Июнь 22, 2022
Neurological
disorders
(NDs)
are
recognized
as
one
of
the
major
health
concerns
globally.
According
to
World
Health
Organization
(WHO),
neurological
main
causes
mortality
worldwide.
include
Alzheimer’s
disease,
Parkinson′s
Huntington′s
Amyotrophic
lateral
sclerosis,
Frontotemporal
dementia,
Prion
Brain
tumor,
Spinal
cord
injury,
and
Stroke.
These
diseases
considered
incurable
because
no
specific
therapies
available
cross
blood-brain
barrier
(BBB)
reach
brain
in
a
significant
amount
for
pharmacological
effect
brain.
There
is
need
development
strategies
that
can
improve
efficacy
drugs
circumvent
BBB.
One
promising
approaches
use
different
types
nano-scale
materials.
nano-based
have
ability
increase
therapeutic
effect,
reduce
toxicity,
exhibit
good
stability,
targeted
delivery,
drug
loading
capacity.
Different
shapes
nanomaterials
been
widely
used
treatment
disorders,
including
quantum
dots,
dendrimers,
metallic
nanoparticles,
polymeric
carbon
nanotubes,
liposomes,
micelles.
nanoparticles
unique
characteristics,
sensitivity,
selectivity,
BBB
when
nano-sized
particles,
imaging
studies
NDs.
In
this
review,
we
briefly
summarized
recent
literature
on
various
their
mechanism
action
disorders.
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 17, 2024
The
unique
anatomical
and
physiological
connections
between
the
nasal
cavity
brain
provide
a
pathway
for
bypassing
blood–brain
barrier
to
allow
direct
brain-targeted
drug
delivery
through
administration.
There
are
several
advantages
of
administration
compared
with
other
routes;
example,
first-pass
effect
that
leads
metabolism
orally
administered
drugs
can
be
bypassed,
poor
compliance
associated
injections
minimized.
Nasal
also
help
maximize
delivery,
allowing
high
pharmacological
activity
at
lower
dosages,
thereby
minimizing
likelihood
adverse
effects
providing
highly
promising
treatment
central
nervous
system
diseases.
aim
this
review
article
was
briefly
describe
structures
brain,
pathways
which
enter
nose,
factors
affecting
methods
improve
systems
application
related
biomaterials,
common
experimental
used
in
intranasal
research,
current
limitations
such
approaches,
solid
foundation
further
in-depth
research
on
(see
Graphical
Abstract
).
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(19)
Опубликована: Янв. 4, 2024
Abstract
The
blood–brain
barrier
(BBB)
is
a
tailored
system
of
capillary
endothelial
cells
intermixed
with
tight
junctions
and
adherent
that
regulates
the
transport
various
materials
substances
between
blood
vasculature
central
nervous
(CNS).
However,
in
cases
brain
diseases,
BBB's
protective
regulatory
effects
hamper
therapeutics
from
reaching
affected
sites
sufficient
quantities.
This
has
so
far
been
leading
challenge
treating
CNS
diseases
disorders.
For
this
problem
to
be
overcome,
recent
research
sought
develop
novel
modalities
achieve
efficient
therapy
alleviate
associated
symptoms.
Therefore,
numerous
strategies
have
operated
years
address
limitations
traditional
invasive
methods,
including
poor
penetration
serious
side
effects.
As
desperately
in‐demand
technology,
nanotheranostics
particularly
shown
promising
results.
Herein,
review
reports
advancements
techniques
nanotechnology‐based
developed
for
neurodegenerative
study
provides
comprehensive
data
on
subject
used
future
studies
management
disorders
diseases.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 26, 2025
Abstract
The
central
nervous
system
(CNS)
diseases
are
major
contributors
to
death
and
disability
worldwide.
However,
the
blood–brain
barrier
(BBB)
often
prevents
drugs
intended
for
CNS
from
effectively
crossing
into
brain
parenchyma
deliver
their
therapeutic
effects.
is
a
semi-permeable
with
high
selectivity.
BBB
primarily
manages
transport
of
substances
between
blood
CNS.
To
enhance
drug
delivery
disease
treatment,
various
brain-based
strategies
overcoming
have
been
developed.
Among
them,
nanoparticles
(NPs)
emphasized
due
multiple
excellent
properties.
This
review
starts
an
overview
BBB’s
anatomical
structure
physiological
roles,
then
explores
mechanisms,
both
endogenous
exogenous,
that
facilitate
NP
passage
across
BBB.
text
also
delves
how
nanoparticles'
shape,
charge,
size,
surface
ligands
affect
ability
cross
offers
different
nanoparticle
classifications.
concludes
examination
current
challenges
in
utilizing
nanomaterials
discusses
corresponding
directions
solutions.
aims
propose
innovative
diagnostic
approaches
design
more
effective
Graphical
abstract
Smart Materials in Medicine,
Год журнала:
2022,
Номер
3, С. 274 - 288
Опубликована: Янв. 1, 2022
We
develop
multidrug-loaded
cubosome
and
spongosome
lipid
nanoparticles
for
targeting
of
endoplasmic
reticulum
stress
as
a
potential
emerging
therapeutic
strategy
against
neuronal
degeneration.
The
multicompartment
organization
the
liquid
crystalline
(LCNPs),
fabricated
by
self-assembly,
was
characterized
cryogenic
transmission
electron
microscopy
(cryo-TEM)
small-angle
X-ray
scattering
(SAXS).
Monoolein-based
LCNPs
co-encapsulated
natural
plant-derived
antioxidant
curcumin,
fish
oil
rich
in
ω-3
polyunsaturated
fatty
acids
(PUFA),
neurotrophin
brain-derived
neurotrophic
factor
(BDNF),
which
is
vital
need
neurogenesis.
neuroprotective
properties
were
vitro
investigated
cellular
model
tunicamycin-induced
(ER)
using
differentiated
human
neuroblastoma
SH-SY5Y
cells
deprieved
from
serum.
intracellular
accumulation
aggregates
misfolded
proteins,
typical
ER
process,
analyzed
fluorescence
co-localization
imaging
staining.
performed
bioassays
established
that
BDNF-loaded
enhanced
cell
survival.
diminution
upon
internalization
quantified
via
changes
Thioflavin
T
fluorescence,
sensitive
marker
protein
aggregation.
with
multi-drug
loading
appear
to
be
promising
candidates
face
challenges
nanomedicine
development
exploiting
ER-stress
mechanisms.
Ageing and Neurodegenerative Diseases,
Год журнала:
2022,
Номер
2(3), С. 11 - 11
Опубликована: Янв. 1, 2022
Alzheimer’s
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
two
pathological
hallmark
lesions:
extracellular
plaques
composed
of
β-amyloid
(Aβ)
peptide
and
intracellular
neurofibrillary
tangles
made
up
highly
phosphorylated
tau
protein.
Over
the
past
decades,
most
disease-modifying
therapies
against
AD
have
been
developed
mainly
on
basis
amyloid
cascade
hypothesis
with
focus
Aβ.
However,
these
agents
yielded
only
limited
benefits
progression,
which
prompts
us
to
revitalize
long-neglected
hypothesis.
Tau
protein
microtubule-associated
protein,
can
stabilize
microtubules,
regulate
microtubule
assembly,
affect
morphology
growth
neuronal
axons.
Much
more
importantly,
degree
pathology
closely
related
cognitive
decline
in
patients
than
that
Aβ
pathology.
Therefore,
tau-targeting
therapy
seems
be
promising
approach
combat
AD.
This
review
describes
research
progress
AD,
an
emphasis
immunotherapy.
The
current
challenges
future
perspectives
this
field
are
also
discussed.
Journal of Drug Delivery Science and Technology,
Год журнала:
2023,
Номер
87, С. 104774 - 104774
Опубликована: Июль 20, 2023
Huntington's
disease
(HD)
is
a
neurological
disorder
characterized
by
reduction
in
medium-spiny
neurons
the
brain.
Currently,
there
no
cure
for
HD
and
treatment
relies
on
symptomatic
therapy.
The
generation
of
stem
cells,
including
neural,
mesenchymal,
pluripotent,
through
conventional
strategies
or
direct
cell
reprogramming
has
revolutionized
therapy
research.
Due
to
their
unique
ability
differentiate
into
variety
self-renew,
grow,
cells
have
become
an
area
interest
treating
various
complex
unresolved
neurodegenerative
disorders.
Nanotechnology
emerged
as
novel
approach
with
great
potential
reduced
side
effects.
Nanoparticles
(NPs)
can
act
nanovehicles
delivering
therapeutic
agents,
siRNAs,
neurotrophic
factors,
different
drugs.
Additionally,
NPs
be
used
alternative
based
antioxidant
reactive
oxygen
species
(ROS)-scavenging
properties
that
protect
neuronal
cells.
Some
even
exhibit
interfere
protein
aggregation
mutant
Huntingtin
proteins
during
processes.
This
review
focuses
most
studied
HD,
polymeric,
lipid-based,
liposomes,
solid
lipid
metal/metal
oxide.
combination
diagnosis
treatment.
been
manage
cellular
microenvironment,
improve
efficiency
drug
delivery
brain
enhance
transplant
survival.
Understanding
characteristics
essential
applying
them
purposes.
In
this
study,
biology
well
benefits
drawbacks
using
its
are
discussed.
Heliyon,
Год журнала:
2023,
Номер
9(11), С. e21227 - e21227
Опубликована: Окт. 20, 2023
The
past
decade
has
witnessed
a
breakthrough
in
novel
strategies
to
treat
cancer.
One
of
the
most
common
cancer
treatment
modalities
is
chemotherapy
which
involves
administering
anti-cancer
drugs
body.
However,
these
can
lead
undesirable
side
effects
on
healthy
cells.
To
overcome
this
challenge
and
improve
cell
targeting,
many
nanocarriers
have
been
developed
deliver
directly
cancerous
cells
minimize
tissues.
majority
research
studies
conclude
that,
using
encapsulated
much
safer
more
effective
alternative
than
delivering
drug
alone
its
free
form.
This
review
provides
summary
types
mainly
studied
for
delivery,
namely:
liposomes,
polymeric
micelles,
dendrimers,
magnetic
nanoparticles,
mesoporous
gold
carbon
nanotubes
quantum
dots.
In
review,
synthesis,
applications,
advantages,
disadvantages,
previous
nanomaterials
are
discussed
detail.
Furthermore,
future
opportunities
possible
challenges
translating
materials
into
clinical
applications
also
reported.
