Nutrients,
Год журнала:
2022,
Номер
14(11), С. 2303 - 2303
Опубликована: Май 30, 2022
Liver
disease
is
a
global
health
burden
with
high
morbidity
and
mortality
worldwide.
injuries
can
develop
into
severe
end-stage
diseases,
such
as
cirrhosis
or
hepatocellular
carcinoma,
without
valid
treatment.
Therefore,
identifying
novel
drugs
may
promote
liver
Phytochemicals,
including
polysaccharides,
flavonoids,
alkaloids,
terpenes,
are
abundant
in
foods
medicinal
plants
have
various
bioactivities,
antioxidation,
immunoregulation,
tumor
killing.
Recent
studies
shown
that
many
natural
polysaccharides
play
protective
roles
models
vitro
vivo,
fatty
disease,
alcoholic
drug-induced
injury,
cancer.
The
mechanisms
of
complex.
Notably,
ferroptosis,
new
type
cell
death
driven
by
iron
lipid
peroxidation,
considered
to
be
the
key
mechanism
hepatic
pathologies.
other
types
phytochemicals
activities
ferroptosis
regulation
provide
therapeutic
strategies
for
ferroptosis-related
diseases.
This
review
summarizes
our
current
understanding
injury
compelling
preclinical
evidence
bioactive
treating
disease.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 117174 - 117174
Опубликована: Авг. 3, 2024
Mangiferin(MGF)
exhibits
crucial
biological
roles,
including
antioxidant
and
anti-inflammatory
functions.
However,
how
to
clearly
elucidate
the
functioning
mechanism
of
MGF
for
inhibiting
cisplatin-induced
hearing
loss
requires
in-depth
investigation.
In
this
work,
we
aimed
at
gaining
insight
into
functions
as
protective
agent
against
cisplatin-triggered
ototoxicity
using
various
assays.
The
variation
reactive
oxygen
species
(ROS)
concentrations
was
determined
with
MitoSOX-Red
2',7'-Dichlorodihydrofluorescein
diacetate
staining
(DCFH-DA).
function
corresponding
in
hair
cell
survival
House
Ear
Institute-Organ
Corti
(HEI-OC1)
line
were
assessed
RNA
sequencing
(RNA-Seq).
Our
findings
demonstrated
that
significantly
alleviated
injury
cells
vitro,
encompassing
lines
cochlear
explants,
well
vivo
models,
C57BL/6
J
mice
zebrafish
larvae.
Mechanistic
studies
revealed
reversed
increased
accumulation
ROS
inhibited
apoptosis
through
mitochondrial-mediated
intrinsic
pathway.
Moreover,
real-time
quantitative
polymerase
chain
reaction
(RT-qPCR)
western
blotting
data
indicated
protected
cisplatin-mediated
via
mitogen-activated
protein
kinase
pathway
(MAPK).
These
has
significant
potential
promise
combating
ototoxicity,
offering
a
foundation
expanded
investigation
therapeutic
approaches
auditory
protection.
Pharmaceuticals,
Год журнала:
2022,
Номер
15(11), С. 1419 - 1419
Опубликована: Ноя. 17, 2022
Honey
and
propolis
have
recently
become
the
key
target
of
attention
for
treating
certain
diseases
promoting
overall
health
well-being.
A
high
content
flavonoids
phenolic
acids
found
in
both
honey
contributes
to
antioxidant
properties
scavenge
free
radicals.
also
exhibited
antibacterial
effects
where
they
act
two
ways,
namely
production
hydrogen
peroxide
(H2O2)
gluconic
following
enzymatic
activities
glucose
oxidase,
which
exerts
oxidative
damage
on
bacteria.
Additionally,
anti-inflammatory
are
mainly
by
reducing
proinflammatory
factors
such
as
interleukins
tumor
necrosis
factor
alpha
(TNF-α).
Their
pain
were
discovered
through
modulation
at
a
peripheral
nociceptive
neuron
or
binding
an
opioid
receptor
higher
center.
The
aforementioned
been
reported
possess
potential
therapeutic
topical
application
exterior
parts
eyes,
particularly
conjunctivitis,
keratitis,
blepharitis,
corneal
injury.
In
contrast,
most
medicinal
values
beneficial
internal
ocular
area,
retina,
optic
nerve,
uvea.
This
review
aims
update
current
discoveries
various
diseases,
including
their
antioxidant,
anti-inflammatory,
antibacterial,
anti-nociceptive
properties.
conclusion,
research
has
shown
that
considerable
promise
eye
illnesses,
although
present
study
designs
primarily
animal
vitro
studies.
Therefore,
there
is
urgent
need
translate
this
finding
into
clinical
setting.
Nutrients,
Год журнала:
2022,
Номер
14(11), С. 2303 - 2303
Опубликована: Май 30, 2022
Liver
disease
is
a
global
health
burden
with
high
morbidity
and
mortality
worldwide.
injuries
can
develop
into
severe
end-stage
diseases,
such
as
cirrhosis
or
hepatocellular
carcinoma,
without
valid
treatment.
Therefore,
identifying
novel
drugs
may
promote
liver
Phytochemicals,
including
polysaccharides,
flavonoids,
alkaloids,
terpenes,
are
abundant
in
foods
medicinal
plants
have
various
bioactivities,
antioxidation,
immunoregulation,
tumor
killing.
Recent
studies
shown
that
many
natural
polysaccharides
play
protective
roles
models
vitro
vivo,
fatty
disease,
alcoholic
drug-induced
injury,
cancer.
The
mechanisms
of
complex.
Notably,
ferroptosis,
new
type
cell
death
driven
by
iron
lipid
peroxidation,
considered
to
be
the
key
mechanism
hepatic
pathologies.
other
types
phytochemicals
activities
ferroptosis
regulation
provide
therapeutic
strategies
for
ferroptosis-related
diseases.
This
review
summarizes
our
current
understanding
injury
compelling
preclinical
evidence
bioactive
treating
disease.
