Cardiology and Angiology An International Journal,
Год журнала:
2022,
Номер
unknown, С. 384 - 391
Опубликована: Ноя. 5, 2022
Background:
Left
ventricular
(LV)
dysfunction
is
the
single
most
accurate
predictor
of
death
and
one
common
lethal
consequences
after
ST
segment
elevation
myocardial
infarction
(STEMI)
that
has
been
substantially
decreased
by
primary
percutaneous
coronary
intervention
(PCI).
This
research
investigated
impact
duration
ischemia
on
severity
improvement
wall
motion
abnormalities
revascularization
40-day
follow-up.
Methods:
study
was
performed
60
STEMI
patients,
treated
with
1ry
PCI
distributed
in
two
groups;
group1:
37
patients
presented
early
before
12h
group
II:
23
late
12h.
Echocardiogram
(ECHO)
done
for
ejection
fraction
(EF)
resting
segmental
(RSWMA)
detection
within
24
h
hospitalization
follow
up
40
days.
Results:
MI
complication
showed
insignificant
difference
between
both
groups.
Wall
score
index
(WMSI)
values
I
were
significantly
relative
to
II
during
follow-up
period
(p=0.001).
Major
LV
from
hospital
admission
(p=0.001)
beginning
chest
pain
compared
II.
Correlation
time
wire
crossing
WMSI
significant
positive
correlation
days
(p=0.016)
negative
EF
(p=0.018).
Conclusions:
Ischemic
≤
12
hours
symptoms
a
degree
recovery
RWMA
days.
Polymers,
Год журнала:
2023,
Номер
15(5), С. 1177 - 1177
Опубликована: Фев. 26, 2023
Cardiovascular
diseases
are
one
of
the
leading
global
causes
morbidity
and
mortality,
posing
considerable
health
economic
burden
on
patients
medical
systems
worldwide.
This
phenomenon
is
attributed
to
two
main
motives:
poor
regeneration
capacity
adult
cardiac
tissues
insufficient
therapeutic
options.
Thus,
context
calls
for
upgrading
treatments
deliver
better
outcomes.
In
this
respect,
recent
research
has
approached
topic
from
an
interdisciplinary
perspective.
Combining
advances
encountered
in
chemistry,
biology,
material
science,
medicine,
nanotechnology,
performant
biomaterial-based
structures
have
been
created
carry
different
cells
bioactive
molecules
repairing
restoring
heart
tissues.
regard,
paper
aims
present
advantages
approaches
tissue
engineering
regeneration,
focusing
four
strategies:
patches,
injectable
hydrogels,
extracellular
vesicles,
scaffolds
reviewing
most
developments
these
fields.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(7), С. 3482 - 3482
Опубликована: Март 23, 2022
The
human
heart
has
the
least
regenerative
capabilities
among
tissues
and
organs,
disease
continues
to
be
a
leading
cause
of
mortality
in
industrialized
world
with
insufficient
therapeutic
options
poor
prognosis.
Therefore,
developing
new
strategies
for
regeneration
is
major
goal
modern
cardiac
biology
medicine.
Recent
advances
stem
cell
biotechnologies
such
as
pluripotent
cells
(hPSCs)
tissue
engineering
hold
great
promise
opening
novel
paths
repair
disease,
although
these
areas
are
still
their
infancy.
In
this
review,
we
summarize
discuss
recent
progress
strategies,
highlighting
cardiomyocyte
maturation,
development
functional
biomaterials
biofabrication
tools,
applications
involving
drug
discovery,
modeling,
medicine
disease.
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100798 - 100798
Опубликована: Сен. 17, 2023
Biomaterial
tissue
engineering
scaffolds
play
a
critical
role
in
providing
mechanical
support,
promoting
cells
growth
and
proliferation.
However,
due
to
the
insulation
inappropriate
stiffness
of
most
biomaterials,
there
is
an
unmet
need
engineer
biomimetic
nanofibrous
cardiac
scaffold
with
tailorable
electrical
properties.
Here,
we
demonstrate
for
first
time
feasibility
generate
novel
type
biocompatible
fibrous
by
blending
elastic
poly(glycerol
sebacate)
(PGS)
conductive
polyaniline
(PANI)
help
nontoxic
carrier
polymer,
poly
(vinyl
alcohol)
(PVA).
Aligned
random
PGS/PANI
are
successfully
obtained
after
electrospinning,
cross-linking,
water
ethanol
wash.
Incorporating
different
concentrations
PANI
into
PGS
fibers,
sheets
show
enhanced
conductivity
slower
degradation
rates
while
maintaining
favorable
hemocompatibility.
The
modulus
range
0.65-2.18
MPa
under
wet
conditions,
which
similar
that
natural
myocardium.
All
these
mats
good
cell
viability
were
able
promote
adhesion
proliferation
H9c2
cells.
Furthermore,
vivo
host
responses
both
aligned
confirm
their
biocompatibility.
Therefore,
have
great
potential
engineering.
Abstract
Muscle
regeneration
is
a
vital
biological
process
that
crucial
for
maintaining
muscle
function
and
integrity,
particularly
the
treatment
of
diseases
such
as
sarcopenia
muscular
dystrophy.
Generally,
tissues
can
self‐repair
regenerate
under
various
conditions,
including
acute
or
chronic
injuries,
aging,
genetic
mutation.
However,
becomes
challenging
beyond
certain
threshold,
in
severe
injuries
progressive
diseases.
In
recent
years,
liposome‐based
nanotechnologies
have
shown
potential
promising
therapeutic
strategies
regeneration.
Liposomes
offer
an
adaptable
platform
targeted
drug
delivery
due
to
their
cell
membrane‐like
structure
excellent
biocompatibility.
They
enhance
solubility,
stability,
while
minimizing
systemic
side
effects
by
different
mechanisms.
This
review
summarizes
advancements,
discusses
current
applications
mechanisms,
highlights
challenges
future
directions
possible
clinical
translation
nanomaterials
It
hoped
this
offers
new
insights
into
development
liposome‐enabled
nanomedicine
address
limitations.
PubMed,
Год журнала:
2025,
Номер
15(1), С. 98 - 107
Опубликована: Янв. 1, 2025
Myocardial
infarction
(MI)
is
the
most
common
heart
disorder
in
patients
with
cardiovascular
disease.
Obstruction
of
blood
flow
to
causes
ischemia
and
results
pump
failure.
This
study
aims
evaluate
effects
porcine
amniotic
epithelial
cell
(pAEC)-based
stem
therapy
alone
combination
cardiomyocytes
understand
its
potential
benefits
MI
treatment.
In
this
study,
we
conducted
using
pluripotent
cells
derived
from
amnion
(AEC)
implanted
into
infarcted
heart.
Nine
domestic
pigs
(Sus
scrofa
domestica),
aged
3-4
months
weighing
35-40
kg,
were
used
as
models.
The
animal
models
divided
three
groups:
placebo
group,
group
treated
pAEC
cells,
combined
cardiomyocyte
cells.
Electrocardiography
(ECG),
pulsed
wave
(PW)
Doppler,
biomarker
examinations
performed
intervention
on
MI.
Single
lesions
demonstrated
improvements
VTI,
particularly
renal
artery,
mitral,
tricuspid
valve
compared
untreated
(placebo).
Notably,
single
significantly
improved
more
than
combining
them
cardiomyocytes.
Treatment
AEC
resulted
significant
function
large
vessels
allowed
us
better
hemodynamics
parameters
injury.
MedComm – Biomaterials and Applications,
Год журнала:
2025,
Номер
4(1)
Опубликована: Март 1, 2025
ABSTRACT
Cardiac
tissue
engineering
presents
a
viable
strategy
for
the
targeted
therapy
of
myocardial
infarction
(MI),
overcoming
limitations
existing
therapies
in
cardiac
repair
and
regeneration.
This
review
explores
potential
stimuli‐responsive
biomaterials
that
engage
with
environment
by
reacting
to
various
environmental
stimuli
including
pH,
temperature,
enzymes,
ultrasound,
reactive
oxygen
species.
These
materials
enable
precise
drug
delivery,
modulate
cellular
responses,
enhance
Biomaterials
such
as
hydrogels,
polymers,
chitosan,
collagen,
alginate
improve
accuracy
effectiveness
localized
delivery
drugs,
stem
cells,
growth
factors,
thus
improving
precision
efficacy
treatments.
The
looks
at
ability
these
mimic
complex
biochemical
mechanical
cues
healthy
myocardium.
challenges
prospects
clinical
applications
are
discussed,
highlighting
their
transformative
while
outcomes
patients
MI.
