Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin

Critical Reviews in Food Science and Nutrition, Год журнала: 2022, Номер 64(15), С. 5073 - 5092

Опубликована: Ноя. 23, 2022

Neohesperidin (hesperetin 7-O-neohesperidoside), a well-known flavanone glycoside widely found in citrus fruits, exhibits variety of biological activities, with potential applications ranging from food ingredients to therapeutics. The purpose this manuscript is provide comprehensive overview the chemical, biosynthesis, and pharmacokinetics profiles neohesperidin, as well therapeutic effects mechanisms neohesperidin against diseases. This literature review covers wide range pharmacological responses elicited by Neohesperidin, including neuroprotective, anti-inflammatory, antidiabetic, antimicrobial, anticancer focus on those responses. Additionally, mechanistic pathways underlying compound's osteoporosis, antiulcer, cardioprotective, hepatoprotective have been outlined. includes detailed illustrations biopharmacokinetics, toxicology, controlled release neohesperidine. demonstrated broad activities treatment complex disorders, neurodegenerative, hepato-cardiac, cancer, diabetes, obesity, infectious, allergic, inflammatory promising candidate for management various etiologically However, further vivo vitro studies are required before clinical trials confirm safety, bioavailability, toxicity neohesperidin.

Язык: Английский

---

Natural plant products as effective alternatives to synthetic chemicals for postharvest fruit storage management

Critical Reviews in Food Science and Nutrition, Год журнала: 2022, Номер 63(30), С. 10332 - 10350

Опубликована: Май 25, 2022

Fruits contain enormous source of vitamins that provides energy to the human body. These are also affluent in essential and vital vitamins, minerals, fiber, health-promoting components, which has led an increase fruit consumption recent years. Though expanded considerably years, use synthetic chemicals ripen or store fruits been steadily increasing, resulting postharvest deterioration. Alternatives should be considered control this problem. Instead utilizing chemicals, study suggests using natural plant products decay. The aim indicates how can useful effective eliminate diseases rather than chemicals. Several electronic databases were investigated as information sources, including Google Scholar, PubMed, Web Science, Scopus, ScienceDirect, SpringerLink, Semantic MEDLINE, CNKI Scholar. current review focused on become more necessary because these vast demands fruits. Pathogen-induced main component so portion get wasted after harvest. Besides, it may occur harmful during harvesting subsequent handling, storage, marketing consumer purchasing causes for numerous endogenous exogenous via activating ROS, oxidative stress, lipid peroxidation, etc. However, pathogenicity halted by originating containing bioactive elements responsible management nutritional deficiency, inflammation, cancer, on. issues arising must controlled resolved before releasing horticultural commodities commercialization. Therefore, pathogens still depends fungicides; however, due problem development fungicide-resistant strains there is a good demand public eradicate pesticides with arrival their intensity specific chemical product. By organic controlling mandatory step take. In addition, antimicrobial packaging have greater impact long-term food security lowering risk increasing longevity shelf life. Taken together, acetaldehyde, hexanal, eugenol, linalool, jasmonates, glucosinolates, oils, many reported combating illnesses guide way storage review.

Язык: Английский

---

Asthma and allergic diseases: Cross talk of immune system and environmental factors

European Journal of Immunology, Год журнала: 2023, Номер 53(6)

Опубликована: Янв. 16, 2023

Air pollution and immune-related diseases including allergy asthma are constantly on the rise worldwide. Thus, a comprehensive investigation of environmentally induced immune regulation is required for deeper understanding disease pathogenesis, progression as well prevention. Here, we summarize current knowledge environmental factors such microbiome or geographical locations with harmful protective effects human health their different routes exposure. This review comprises brief outline regarding latest findings interaction innate adaptive system, exemplarily one factor, respectively.

Язык: Английский

---

Biology of cyclooxygenase-2: An application in depression therapeutics

Frontiers in Psychiatry, Год журнала: 2022, Номер 13

Опубликована: Ноя. 10, 2022

Depressive Disorder is a common mood disorder or affective that dominated by depressed mood. It characterized high incidence and recurrence. The onset of depression related to genetic, biological psychosocial factors. However, the pathogenesis still unclear. In recent years, there has been an increasing amount research on inflammatory hypothesis depression, in which cyclo-oxygen-ase 2 (COX-2), pro-inflammatory cytokine, closely associated with depression. A variety chemical drugs natural products have found exert therapeutic effects modulating COX-2 levels. This paper summarizes relationship between terms neuroinflammation, intestinal flora, neurotransmitters, HPA axis, mitochondrial dysfunction hippocampal neuronal damage, can provide reference for further preventive control, clinical treatment scientific

Язык: Английский

---

Muscone with Attenuation of Neuroinflammation and Oxidative Stress Exerts Antidepressant-Like Effect in Mouse Model of Chronic Restraint Stress

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 10

Опубликована: Сен. 30, 2022

Major depressive disorder (MDD) is a common mental with high morbidity. Stress negatively affects for MDD development, whereby transport of stress-induced inflammatory mediators to the central nervous system (CNS) associated etiology mood disorders. Muscone pharmacologically active ingredient isolated from musk, anti-inflammatory and neuroprotective effects. We hypothesized that muscone may ameliorate depression-like behavior by regulating responses. To test this hypothesis, we used chronic restraint stress (CRS) depression model, CRS mice were treated (10 mg/kg, i.g., respectively) 14 days. The effects drug on depressive-like behaviors evaluated via open field (OFT), novelty-suppressed feeding (NSFT), tail suspension (TST), forced swimming (FST). Quantitative reverse transcription-PCR (qRT-PCR) was utilized assess levels proinflammatory cytokines (IL-6, TNF-α, COX2, IL-1) (IL-4 IL-10). also determined oxidative factors (malondialdehyde, superoxide dismutase, glutathione peroxidase), as well doublecortin (DCX) expression immunofluorescence. results showed improved after treatment. significantly neurogenesis in mouse hippocampus decreased both peripheral systems. In conclusion, work first demonstrate has an antidepressant effect using model. Oxidative stress, neurogenesis, pathways are key affected represent new therapeutic targets treat MDD, impact. These target MDD.

Язык: Английский

---