Focusing on development of novel sampling approaches and alternative therapies for COVID-19: Are they still useful in an era after the pandemic? DOI Open Access
Tetsuya Asakawa

BioScience Trends, Год журнала: 2022, Номер 16(6), С. 386 - 388

Опубликована: Дек. 8, 2022

The different viral characteristics of the Omicron variant SARS-CoV-2 have fundamentally changed people's view concerning COVID-19. Many alternative sampling approaches and therapies been developed that may be better suited to variant, such as a saline gargle detect nasal irrigation with chlorine dioxide. mechanisms these methods are briefly summarized here. Development novel sampling/therapeutic for COVID-19 is crucial due uncertain future emerging respiratory viruses, their efficiency/safety needs verified in post-pandemic era since infections tract similar route transmission SARS-CoV-2.

Язык: Английский

Exploring the Potential of Stem Cells in Modulating Gut Microbiota and Managing Hypertension DOI
Asma Ismail Mahmod, Kayatri Govindaraju, Yogeswaran Lokanathan

и другие.

Stem Cells and Development, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Hypertension, commonly known as high blood pressure, is a significant health issue that increases the risk of cardiovascular diseases, stroke, and renal failure. This condition broadly encompasses both primary secondary forms. Despite extensive research, underlying mechanisms systemic arterial hypertension-particularly hypertension, which has no identifiable cause affected by genetic lifestyle agents-remain complex not fully understood. Recent studies indicate an imbalance in gut microbiota, referred to dysbiosis, may promote affecting pressure regulation through metabolites such short-chain fatty acids trimethylamine N-oxide. Current antihypertensive medications face limitations, including resistance adherence issues, highlighting need for novel therapeutic approaches. Stem cell therapy, emerging field regenerative medicine, shows promise addressing these challenges. cells, with mesenchymal stem cells being prime example, have regenerative, anti-inflammatory, immunomodulatory properties. Emerging research indicates can modulate reduce inflammation, improve vascular health, potentially aiding management. Research shown positive impact on microbiota various disorders, suggesting their potential role treating hypertension. review synthesizes recent interactions between By offering thorough analysis current literature, it highlights key insights, uncovers critical gaps, identifies trends will inform guide future investigations this rapidly advancing field.

Язык: Английский

Процитировано

0
Gene mutation estimations via mutual information and Ewens sampling based CNN & machine learning algorithms DOI
Wanyang Dai

Journal of Applied Statistics, Год журнала: 2025, Номер unknown, С. 1 - 33

Опубликована: Фев. 3, 2025

Язык: Английский

Процитировано

0
Subinhibitory concentrations of Rhubarb Palmatum and its main monomers causing inhibition of alpha-hemolysin virulence in Staphylococcus aureus USA300 DOI
Miao Liu,

Manlin Ding,

Xinyi Ou

и другие.

South African Journal of Botany, Год журнала: 2025, Номер 179, С. 39 - 47

Опубликована: Фев. 10, 2025

Язык: Английский

Процитировано

0
A Novel Paradigm on Data and Knowledge-Driven Drug Formulation Development: Opportunities and Challenges of Machine Learning DOI
Xinrui Wang,

Zhenda Liu,

Lin Xiao

и другие.

Journal of Industrial Information Integration, Год журнала: 2025, Номер unknown, С. 100796 - 100796

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Insights into the antibacterial activity of Limosilactobacillus fermentum curd isolate against gram-positive and gram-negative pathogenic bacteria DOI
Suchhanda Nandi, Shyamapada Mandal

Deleted Journal, Год журнала: 2025, Номер unknown, С. 100034 - 100034

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Chinese Medicine for the Community—Present and the Future DOI
Vivian Lee,

Ida Ngai Tan Chow

Quality of life in Asia, Год журнала: 2025, Номер unknown, С. 259 - 267

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Analysis of causal effects on metabolic syndrome and inflammatory bowel disease: a Mendelian randomization study DOI Creative Commons
Danyang Zhang,

Haitao Shi,

C C Wei

и другие.

Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 28, 2025

Metabolic syndrome (MetS) is a conglomerate of metabolic abnormalities including hypertension, obesity, hyperglycemia, hypertriglyceridemia, and low levels high-density lipoprotein cholesterol (HDL-C). The relationship between MetS Inflammatory Bowel Disease (IBD) has received lot attention lately. Epidemiological investigation yet to determine if the two illnesses are causally related. To investigate causal link IBD levels, we screened publically available genome-wide association study (GWAS) data using Mendelian randomization (MR) analysis. aimed comprehensively analyze each component MetS, fasting blood glucose(FBG), HDL-C, triglyceride(TG), waist circumference(WC), on risk its subtypes via univariate, two-way, multivariate MR (MVMR) methods. We selected independent genetic variants as instrumental variables (IVs) from published IEU OpenGWAS project IIBDGC (International Genetic Consortium), used infer potential effects them, variety methods (random effect inverse variance weighting (IVW), weighted median, MR-Egger regression, etc.) ensure robustness effects. Univariate two-sample (TSMR) revealed that WC was significantly linked Crohn's disease (CD) (OR = 1.659; 95% CI: 1.144-2.405; p 0.008) 1.383; 1.050-1.822; 0.021). However, MVMR did not support this finding. In analysis, hypertension predicted be positively associated with 2.322516, 1.097713-4.91392, 0.0275365), whereas FBG confirmed reduce CD in studies 0.4346427, 0.2685399-0.7034868, 0.0006948939). Other elements correlate IBD. Although confounding factors cannot completely ruled out, certain components, such WC, may impact addition highlighting need for more research understand underlying mechanisms indirect components IBD, offers insight into therapeutic treatment decisions patients MetS.

Язык: Английский

Процитировано

0
A Direct Relationship Between ‘Blood Stasis’ and Fibrinaloid Microclots in Chronic, Inflammatory, and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment DOI Creative Commons
Douglas B. Kell, Etheresia Pretorius, Huihui Zhao

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(5), С. 712 - 712

Опубликована: Май 12, 2025

'Blood stasis' (syndrome) (BSS) is a fundamental concept in Traditional Chinese Medicine (TCM), where it known as Xue Yu (). Similar concepts exist Korean ('Eohyul') and Japanese Kampo medicine (Oketsu). Blood stasis considered to underpin large variety of inflammatory diseases, though an exact equivalent Western systems yet be described. Some time ago we discovered that blood can clot into anomalous amyloid form, creating what have referred fibrinaloid microclots. These microclots occur great many chronic, diseases are comparatively resistant fibrinolysis, thus the ability block microcapillaries hence lower oxygen transfer tissues, with multiple pathological consequences. We here develop idea precisely relate to, largely mechanistically responsible for, traditional (a term also used by Virchow). First, associated all stasis. Secondly, blocking red cell transport, provide simple mechanistic explanation for physical slowing down ('stasis') flow. Thirdly, herbal formulae proposed treat these especially Fu Zhu its derivatives, anticoagulatory anti-inflammatory, consistent they actually helping levels microclots, plausibly part catalysis polymerization fibrinogen form. rehearse some actions constituent herbs specific bioactive molecules contain. Consequently, such formulations (and their components), which little science medicine, would seem offer opportunity novel, safe, useful treatments chronic display including Myalgic Encephalopathy/Chronic Fatigue Syndrome, long COVID, even ischemic stroke.

Язык: Английский

Процитировано

0
Targeting intestinal microecology: potential intervention strategies of traditional Chinese medicine for managing hypertension DOI Creative Commons
Zhihua Yang, Shanshan Lin,

Yangxi Liu

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Май 31, 2023

Hypertension has become one of the major public health problems in world. At present, pathogenesis hypertension still not been completely elucidated. In recent years, an increasing evidence shows that intestinal microecology is closely related to hypertension, which provides a new thinking for prevention and treatment hypertension. Traditional Chinese medicine (TCM) unique advantages Taking as target, it possible interpreting scientific connotation TCM by updating concept so improve therapeutic effect. our study, clinical was systematicly summarized. And relationship among TCM, analyzed. addition, methods regulates prevent treat were presented, provide research ideas

Язык: Английский

Процитировано

8
An Update on the Mutual Impact between SARS-CoV-2 Infection and Gut Microbiota DOI Creative Commons
Shaoshuai Li, Yang Zhou, Dongmei Yan

и другие.

Viruses, Год журнала: 2022, Номер 14(8), С. 1774 - 1774

Опубликована: Авг. 15, 2022

The gut microbiota is essential for good health. It has also been demonstrated that the can regulate immune responses against respiratory tract infections. Since outbreak of COVID-19 pandemic, accumulating evidence suggests there a link between severity and alteration one’s microbiota. composition be profoundly affected by vice versa. Here, we summarize observations mutual impact SARS-CoV-2 infection composition. We discuss consequences mechanisms bi-directional interaction. Moreover, cross-reactivity commensal bacteria, which represents previously overlooked connection bacteria. Finally, progress in managing utilizing microbial interventions.

Язык: Английский

Процитировано

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