The Efficacy and Safety of Budesonide/Glycopyrronium/Formoterol in the Treatment of COPD in the Elderly

Contrast Media & Molecular Imaging, Год журнала: 2022, Номер 2022(1)

Опубликована: Янв. 1, 2022

Chronic obstructive pulmonary disease (COPD) is a major and difficult of the chronic respiratory system that common frequent, with huge burden. The aim this study was to investigate efficacy safety budesonide/glyburide/formoterol fumarate (BGF) in treatment COPD.A comprehensive literature search conducted PubMed, Embase, Cochrane Library, Web Science. basic features seven pieces were identified using strategy. sample size range 130∼1264.The effects BGF increased FEV1 patients COPD (mean difference = 2.86, 95%CI: 2.71-3.01, p < 0.00001). improved ≥1 TEAE COPD, not statistically significant after (Odds rate 1.00, 0.85-1.17, p=0.97). TEAEs related (odds 1.27, 95% CI: 1.03-1.57, p=0.02). decreased serious -0.02, -0.03--0.00, p=0.04). death 0.77, 0.31-1.97, p=0.59). hypertension 0.92, 0.44-1.89, p=0.81), treatment. pneumonia 1.55, 0.81-2.97, p=0.19), FEV1, treatment, COPD.This elucidates view providing clinical reference.

Язык: Английский

---

Dynamic changes in marker components during the stir-frying of Pharbitidis Semen, and network analysis of its potential effects on nephritis

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Март 14, 2023

Introduction: Pharbitidis Semen (PS) has been widely used in traditional Chinese medicine to treat several diseases such as nephritis. PS is usually stir-fried enhance its therapeutic efficacy before use clinical practice. However, the changes phenolic acids during stir-frying and mechanisms of their effects on nephritis are still unclear. Methods: Here, we studied processing-induced chemical elucidated mechanism treatment We determined levels 7 raw (RPS) (SPS) using high-performance liquid chromatography, analyzed dynamic compositional stir-frying, network analysis molecular docking predict verify compound targets pathways corresponding Results: The suggestive a transesterification reaction. Pathway revealed that were mainly enriched AGE-RAGE, hypoxia-inducible factor-1, interleukin-17, tumor necrosis factor signaling among others. Molecular results showed had good binding ability with key nephritic targets. Discussion: potential pharmaceutical basis, targets, treating explored. Our findings provide scientific basis for

Язык: Английский

---

A Review on the Medicinal Plants for Tobacco Cessation

SVOA Dentistry, Год журнала: 2023, Номер 4(3), С. 102 - 109

Опубликована: Май 31, 2023

Tobacco use is one of the major causes mortality due to non-communicable diseases. The chemicals present in tobacco affect almost all parts body and cause various Although majority users are aware about ill effects tobacco, they unable quit because presence highly addictive substance nicotine. experience withdrawal symptoms their attempt which further discourages them from quitting. Despite fact that Nicotine replacement therapy (NRT) found be effective, it associated with several side effects. Natural products or herbal remedies safer alternatives NRT. Numerous herbs antioxidant antianxiety properties have been tried combat nicotine thereby facilitate cessation. Alternative therapies those easily available, fewer can used reduce burden world. In this review, we enlisted for cessation medicinal on tobacco.

Язык: Английский

---

UHPLC–HRMS based saponins profiling of three morphological regions in American ginseng (Panax quinquefolium L.) and their correlation with the antioxidant activity

Food Science and Biotechnology, Год журнала: 2023, Номер 33(7), С. 1685 - 1696

Опубликована: Ноя. 28, 2023

Язык: Английский

---