Pathology - Research and Practice, Год журнала: 2023, Номер 248, С. 154657 - 154657
Опубликована: Июль 1, 2023
Язык: Английский
Pathology - Research and Practice, Год журнала: 2023, Номер 253, С. 155015 - 155015
Опубликована: Дек. 6, 2023
Язык: Английский
Процитировано
25
Extracellular Vesicle, Год журнала: 2023, Номер 2, С. 100025 - 100025
Опубликована: Май 20, 2023
Extracellular vesicles (EVs) are membrane-bound nanoparticles with different types of cargo released by cells and postulated to mediate functions such as intercellular communications. Recent studies have shown that long non-coding RNAs (lncRNAs) or their fragments present within EVs. LncRNAs a heterogeneous group RNA species length exceeding 200 nucleotides diverse in based on localization. While lncRNAs known for important cellular regulation, presence role EVs only recently been explored. certain observed EV-lncRNAs be tissue- disease-specific, it remains determined whether not this is global observation. Nonetheless, these molecules demonstrated promising potential serve new diagnostic prognostic biomarkers. In review, we critically evaluate the EV-derived several prevalent diseases, including cancer, cardiovascular neurodegenerative specific focus
Язык: Английский
Процитировано
24
Pathology - Research and Practice, Год журнала: 2024, Номер 257, С. 155316 - 155316
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
12
Non-Coding RNA, Год журнала: 2024, Номер 10(1), С. 12 - 12
Опубликована: Фев. 6, 2024
Extracellular vesicles (EVs) are defined as subcellular structures limited by a bilayer lipid membrane that function important intercellular communication transporting active biomolecules, such proteins, amino acids, metabolites, and nucleic including long non-coding RNAs (lncRNAs). These cargos can effectively be delivered to target cells induce highly variable response. LncRNAs functional composed of at least 200 nucleotides do not code for proteins. Nowadays, lncRNAs circRNAs known play crucial roles in many biological processes, plethora diseases cancer. Growing evidence shows an presence lnc- EVs, generating downstream responses ultimately affect cancer progression mechanisms, angiogenesis. Moreover, studies have revealed some tumor promote angiogenesis secreting which endothelial take up new vessel formation. In this review, we aim summarize the bioactive EVs with cargo their effect on Also, discuss future clinical strategies treatment based current knowledge circ- lncRNA-EVs.
Язык: Английский
Процитировано
9
Pathology - Research and Practice, Год журнала: 2024, Номер 260, С. 155374 - 155374
Опубликована: Май 29, 2024
Язык: Английский
Процитировано
8
Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101179 - 101179
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Translational Oncology, Год журнала: 2025, Номер 53, С. 102210 - 102210
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
1
Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Язык: Английский
Процитировано
1
Cancers, Год журнала: 2022, Номер 15(1), С. 286 - 286
Опубликована: Дек. 31, 2022
Exosomes are nanovesicles secreted into biofluids by various cell types and have been implicated in different physiological pathological processes. Interestingly, a plethora of studies emphasized the mediating role exosomes bidirectional communication between donor recipient cells. Among cargoes exosomes, long non-coding RNAs (lncRNAs) identified as crucial regulators cancer cells immune tumor microenvironment (TME) that can interfere with innate adaptive responses to affect therapeutic efficiency. Recently, few major focused on exosomal lncRNA-mediated interaction infiltrated TME. Nevertheless, dearth pertains regulating lncRNAs is still early stages. Comprehensive mechanisms immunity not well understood. Herein, we provide an overview immunomodulatory function treatment resistance. In addition, also summarize potential strategies toward
Язык: Английский
Процитировано
31
Journal of Experimental & Clinical Cancer Research, Год журнала: 2023, Номер 42(1)
Опубликована: Авг. 29, 2023
Abstract Lung cancer remains the leading cause of cancer-related deaths globally, and survival rate low despite advances in diagnosis treatment. The progression lung is a multifaceted dynamic phenomenon that encompasses interplays among cancerous cells their microenvironment, which incorporates immune cells. Exosomes, are small membrane-bound vesicles, released by numerous cell types normal stressful situations to allow communication between Tumor-derived exosomes (TEXs) possess diverse neo-antigens cargoes such as proteins, RNA, DNA have unique molecular makeup reflecting tumor genetic complexity. TEXs contain both immunosuppressive immunostimulatory factors may play role immunomodulation influencing innate adaptive components. Moreover, they transmit signals contribute promoting metastasis, epithelial-mesenchymal transition (EMT), angiogenesis, immunosuppression. This makes them valuable resource for investigating environment tumors, could pave way development non-invasive biomarkers aid prognosis, diagnosis, immunotherapy cancer. While checkpoint inhibitor (ICI) has shown promising results treating initial-stage cancers, most patients eventually develop resistance over time. Emerging evidence demonstrates serve prognostic biomarker immunotherapeutic response significant impact on systemic suppression advancement. Therefore, understanding tumorigenesis immunotherapies an exciting research area needs further investigation. review highlights key contributors advancement clinical significance immune-oncology, including possible use monitoring disease well emerging shreds regarding possibility using targets improve therapy.
Язык: Английский
Процитировано
21