Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis

Pharmaceuticals, Год журнала: 2023, Номер 16(1), С. 130 - 130

Опубликована: Янв. 16, 2023

Background: The COVID-19 pandemic represents one of the world’s most important challenges for global public healthcare. Various studies have found an association between severe vitamin D deficiency and COVID-19-related outcomes. Vitamin plays a crucial role in immune function inflammation. Recent data suggested protective health purpose this meta-analysis trial sequential analysis (TSA) was to better explain strength supplementation risk mortality admission intensive care units (ICUs) patients with COVID-19. Methods: We searched four databases on 20 September 2022. Two reviewers screened randomized clinical trials (RCTs) assessed bias, independently duplicate. pre-specified outcomes interest were ICU admission. Results: identified 78 bibliographic citations. After reviewers’ screening, only five RCTs be suitable our analysis. performed meta-analyses then TSAs. administration results decreased death (standardized mean difference (95% CI): 0.49 (0.34–0.72) 0.28 (0.20–0.39), respectively). TSA showed that, since pooling reached definite sample size, positive is conclusive. that z-curve inside alpha boundaries, indicating need further studies. Discussion: respective TSAs suggest definitive hospitalization.

Язык: Английский

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Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19

Nature Reviews Rheumatology, Год журнала: 2023, Номер 19(5), С. 265 - 287

Опубликована: Март 28, 2023

Язык: Английский

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Effect of Cholecalciferol Supplementation on the Clinical Features and Inflammatory Markers in Hospitalized COVID-19 Patients: A Randomized, Open-Label, Single-Center Study

Nutrients, Год журнала: 2022, Номер 14(13), С. 2602 - 2602

Опубликована: Июнь 23, 2022

Recent studies showed that a low 25-hydroxyvitamin D (25(OH)D) level was associated with higher risk of morbidity and severe course COVID-19. Our study aimed to evaluate the effects cholecalciferol supplementation on clinical features inflammatory markers in patients A serum 25(OH)D determined 311 COVID-19 patients. Among them, 129 were then randomized into two groups similar concomitant medication. Group I (n = 56) received bolus at dose 50,000 IU first eighth days hospitalization. Patients from II 54) did not receive supplementation. We found significant differences between preferential increase Δ ninth day hospitalization (p < 0.001). The negatively number bed (r −0.23, p 0.006); we observe other benefits receiving an oral cholecalciferol. Moreover, I, neutrophil lymphocyte counts significantly 0.04; 0.02), while C-reactive protein lower 0.02). 100,000 cholecalciferol, compared those without supplementation, decrease frequencies CD38++CD27 transitional CD27−CD38+ mature naive B cells 0.006 0.02) CD27−CD38− DN Thus, rise caused by vitamin insufficient deficient may positively affect immune status hence

Язык: Английский

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Consensus and Controversial Aspects of Vitamin D and COVID-19

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2022, Номер 108(5), С. 1034 - 1042

Опубликована: Дек. 8, 2022

Abstract Objective This work aims to review and discuss controversial topics in the field of vitamin D, SARS-CoV-2 infection, COVID-19. Methods The International Conferences “Controversies Vitamin D” are a series workshops that started 2017 featuring international experts leaders D research clinical practice. fifth annual conference was held Stresa, Italy, September 15 18, 2021. Evidence Before event, participants reviewed available studies on their assigned topic, drafted related abstract, presented findings at time conference. Relevant literature became since also discussed within panel updated accordingly. Consensus abstracts had been merged prepare preliminary document. After presentations, in-depth discussions open sessions led consensus. document subsequently modified according up-to-date inclusion. Conclusions There is quite consistent evidence for an association between low 25 OH (25(OH)D) levels poor COVID-19 outcomes, despite heterogeneous publications variable quality. However, status patients might reflect reverse causality. supplementation have positive role prevention. supporting beneficial effect treatment decreasing risk complications conflicting. Conclusive statements regarding this context await high-quality, randomized controlled trials.

Язык: Английский

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A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 7, 2025

Current evidence is inconsistent on whether vitamin D supplementation can prevent COVID-19 infection or improve its clinical outcomes. To better understand and look into the issue, we went through background knowledge of D, searched in Pubmed [by using key words title containing "randomized trial", "COVID-19", "vitamin (25-hydroxyvitamin cholecalciferol, calcidiol, calcifediol) supplementation"] for publications studies D/supplementation patients, especially those about randomized trials (RCTs). After reviewing these papers, did a short review pathophysiology COVID-19, summarized features 25 RCTs text tabulated table some features, commented, compared discussed differences between (for example, change serum 25-hydroxyvitamin concentration from nmol/L to ng/mL, making comparison easier). The take-home question that an important indicator effect correction but may not be reliable predicting outcomes COVID-19.

Язык: Английский

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Mechanistic Insight into the role of Vitamin D and Zinc in Modulating Immunity Against COVID-19: A View from an Immunological Standpoint

Biological Trace Element Research, Год журнала: 2023, Номер 201(12), С. 5546 - 5560

Опубликована: Март 8, 2023

The pathophysiology of coronavirus disease-19 (COVID-19) is characterized by worsened inflammation because weakened immunity, causing the infiltration immune cells, followed necrosis. Consequently, these pathophysiological changes may lead to a life-threatening decline in perfusion due hyperplasia lungs, instigating severe pneumonia, and fatalities. Additionally, acute respiratory syndrome 2 (SARS-CoV-2) infection can cause mortality viral septic shock, resulting from unrestrained backfiring reactions pathogen. Sepsis premature organ failure COVID-19 patients, as well. Notably, vitamin D its derivatives minerals, such zinc magnesium, have been reported improve system against illnesses. This comprehensive review aims provide updated mechanistic details immunomodulators. this also focuses on their role illnesses, while specifically delineating plausibility employing them preventive therapeutic agent current future pandemics an immunological perspective. Furthermore, will attract attention health professionals, nutritionists, pharmaceuticals, scientific communities, it encourages use micronutrients for purposes, well promoting benefits healthy lifestyle wellbeing.

Язык: Английский

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The Effect of Vitamin D Supplementation on the Length of Hospitalisation, Intensive Care Unit Admission, and Mortality in COVID-19—A Systematic Review and Meta-Analysis

Nutrients, Год журнала: 2023, Номер 15(15), С. 3470 - 3470

Опубликована: Авг. 5, 2023

The coronavirus disease 2019 (COVID-19) pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has become a global health crisis and pushed researchers physicians to discover possible treatments improve outcome of their patients. Vitamin D, known for its role in immune system function, been hypothesized play COVID-19 treatment. A systematic review meta-analysis were conducted evaluate efficacy vitamin D supplementation COVID-19, focusing on length hospital stay (LOS), admission intensive care unit (ICU), mortality. Thirteen randomized controlled trials (RCTs) included, revealed that high-dose showed potential benefits reducing ICU rates patients with COVID-19. However, overall effect mortality did not reach statistical significance. While this suggests stays patients, caution is warranted due high heterogeneity limitations included studies. Further large-scale consistent study characteristics are needed provide more robust evidence regarding therapeutic outcomes.

Язык: Английский

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Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy

Inflammopharmacology, Год журнала: 2023, Номер 32(1), С. 249 - 271

Опубликована: Ноя. 13, 2023

Abstract Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose this study was evaluate clinical efficacy vitamin D (VD) in COVID-19 long COVID-19, explain discrepancy outcomes highlight potential impact metformin on VD recent articles. Articles January 2022 August 2023 were selected for review. objective achieved by reviewing, analyzing, discussing articles demonstrating (1) mechanism action (2) observational or randomized trials (RCTs) that support not beneficial effects COVID. (3) genetic non-genetic reasons variation VD. collected electronic databases such as PubMed, Scopus, MEDLINE, Google Scholar, Egyptian Knowledge Bank, Science Direct, Cochrane Database Systematic Reviews. Twenty three studies conducted vitro animal models indicated may act through protecting respiratory system antimicrobial peptide cathelicidins, reducing lung inflammation, regulating innate adaptive immune functions up regulation autophagy gene activity. Our review identified 58 met criteria. number publications supporting a activity treating 49 (86%), including 12 meta-analyses. Although total patients included all 14,071,273, role 14,029,411 (99.7%). Collectively, extensive decisive relationship between low levels severity mortality outcomes. Importantly, evidence intervention has demonstrated effectiveness supplements COVID-19. Furthermore, results 4 supported alleviating symptoms disease. However, eight RCTs one meta-analysis contain low-grade against Twenty-five have addressed association VDR DBP polymorphisms treatment failure Impaired signaling underlie variability mechanisms. Interestingly, studies, therapeutic possibly improving AMPK enhancing In conclusion, been significantly strengthened over past 18 months, with several meta-analyses reporting conclusive supplementation highlighting improve sensitivity

Язык: Английский

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Vitamin D Levels as a Marker of Severe SARS-CoV-2 Infection

Life, Год журнала: 2024, Номер 14(2), С. 210 - 210

Опубликована: Янв. 31, 2024

The SARS-CoV-2 virus may cause severe infection, which is associated with diverse clinical manifestations. Vitamin D has immunomodulating properties and enhance the body’s defense system against invading pathogenic organisms. aim was to assess 25(OH)D3 levels in patients hospitalized for infection from explore relationship between outcomes. In a group of 88 control matched age sex, were analyzed. Levels 17.36 ± 8.80 ng/mL (mean SD) compared 24.34 10.34 group, respectively, p < 0.001 (Student’s t-test). significantly related outcomes, i.e., survival as opposed non-survival, more deficiency (0–10 ng/mL) insufficiency (10–20 had fatal outcome those vitamin sufficiency (p 0.001, chi-square test, Fisher’s exact test). inversely C-reactive protein (CRP), ferritin, d-dimer, fibrinogen linear regression analysis, beta coefficient variation, −0.176, −0.160, −0.178, −0.158, respectively). observed disease

Язык: Английский

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Therapeutic effects of vitamin D supplementation on COVID-19 aggravation: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 27, 2024

Background The therapeutic effects of vitamin D supplementation on Coronavirus disease 2019 (COVID-19) aggravation remain controversial and inconclusive. To probe into this contentious issue, we performed the present meta-analysis randomized controlled trials (RCTs). Methods Literature published up to June 2023 was retrieved from Cochrane Library, PubMed, Web Science Embase. RCTs assessing mortality, intensive care unit (ICU) admission, mechanical ventilation (MV), length hospitalization (LOH), inflammatory markers containing C-reactive protein (CRP), D-dimer, interleukin-6 (IL-6), lactate dehydrogenase (LDH) were included. 19 involved in analysis conducted subgroup analyses baseline COVID-19 severity administration. Results In subgroup, statistically significant moderate severe group observed ICU admission (OR 0.43, 95% CI 0.23, 0.80; p = 0.008), MV 0.44, 0.27, 0.72; 0.001) LOH (SMD –0.49, –0.92, −0.06; 0.027). administration 0.39, 0.16, 0.97; 0.044), 0.18, 0.07, 0.46; 0.000) –0.50, –0.96, −0.04; 0.034) more pronounced patients supplied with multiple-dose than single-dose. Although result mortality showed no effect, it indicated a reduced trend 0.87, 0.63, 1.12; &gt; 0.05). results reached statistical differences. Conclusion This revealed that multiple doses less apt need have shorter hospital stays.

Язык: Английский

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