Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress DOI Creative Commons

Hurmat Malik,

Muhammad Usman, Mehreen Arif

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Авг. 16, 2023

Introduction: Post-traumatic stress disorder (PTSD) is a chronic mental illness triggered by traumatic experiences such as wars, natural disasters, or catastrophes, and it characterized anxiety, depression cognitive impairment. Diosgenin steroidal sapogenin with known neuroprotective antioxidant properties. This study aimed to assess the pharmacological potential of diosgenin in single prolonged (SPS) model PTSD, plus other behavioral models along any consequent alterations brain neurochemistry male mice. Methodology: SPS was induced restraining animals for 2 h, followed 20 min forced swim, recuperation 15 min, finally, exposure ether induce anesthesia. The SPS-exposed were treated (20, 40, 60 mg/kg) compared positive controls, fluoxetine donepezil, then they observed changes anxiety/depression-like behaviors, After screening, postmortem serotonin, noradrenaline, dopamine, vitamin C, adenosine its metabolites inosine hypoxanthine quantified frontal cortex, hippocampus, striatum high-performance liquid chromatography. Additionally, animal serum screened corticosterone levels. Results: results showed that reversed anxiety- depression-like ameliorated impairment dose-dependent manner. restored monoamine C levels dose-dependently modulated regions. also reinstated otherwise increased Conclusion: findings suggest may be candidate improving symptoms PTSD.

Язык: Английский

Dioscin alleviates the dysfunction of fibroblast-like synoviocytes by circ_0008267/miR-942-5p/FKBP5 axis during rheumatoid arthritis DOI
Lifeng Chen, Xu Li, Yujing Zhang

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Язык: Английский

Процитировано

0
Steroidal saponins: a treasure trove of natural resources that require urgent development DOI
Zhiqiang Sun, Chunmei Zhong, Hongdan Zhang

и другие.

Phytochemistry Reviews, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Язык: Английский

Процитировано

0
Evaluation of the Effects of Thymoquinone on RAGE/NOX4 Expressions and Brain Tissue Morphometry in Experimental Alzheimer’s Disease Induced by Amyloid Beta 1–42 Peptide DOI Creative Commons
Şükrü Ateş, Harun Ülger, Sümeyye Uçar

и другие.

Biomolecules, Год журнала: 2025, Номер 15(4), С. 543 - 543

Опубликована: Апрель 7, 2025

The onset of Alzheimer’s disease (AD) is attributed to widespread amyloid beta (Aβ) plaque accumulation, tau hyperphosphorylation, oxidative stress, and neuroinflammation. However, the underlying mechanism AD remains unclear, no curative treatment currently exists. aim was investigate effect thymoquinone by suppressing RAGE/NOX4 pathway in AD. Mice (n = 60) were divided into five groups, an experimental model induced Aβ1–42 peptide established two groups. We also administered 5 mg/kg (TMQ) mice for its properties slow or treat neurodegeneration Behavioral tests memory emotional states, micro-computed tomography (Micro CT) assess brain volume, ELISA measure malondialdehyde (MDA) levels, hematoxylin eosin staining (H&E) evaluate neuronal degeneration used. Immunohistochemical (IHC), Western blot (WB), real-time polymerase chain reaction (PCR) methods used inhibitory TMQ on a receptor advanced glycation end products (RAGE)/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) signaling results showed that may have ameliorative effects memory, spatial learning, learning ability, anxiety has antioxidative decreasing MDA levels ELSIA method (p < 0.05). There marked increase compared other groups concluded could ameliorate H&E suppress IHC WB analysis. be therapeutic reducing AB expression level analysis Real-time PCR APP 0.05), RAGE, NOX4 0.05) gene expressions reduced TMQ. In conclusion, high potential effective preventive strategy can developed with more comprehensive studies

Язык: Английский

Процитировано

0
Classic Famous Prescription Kai-Xin-San Ameliorates Alzheimer’s Disease via the Wnt/β-Catenin Signaling Pathway DOI

Xiaoxiao Shan,

Shujie Lv,

Peng Huang

и другие.

Molecular Neurobiology, Год журнала: 2023, Номер 61(4), С. 2297 - 2312

Опубликована: Окт. 24, 2023

Язык: Английский

Процитировано

10
Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress DOI Creative Commons

Hurmat Malik,

Muhammad Usman, Mehreen Arif

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Авг. 16, 2023

Introduction: Post-traumatic stress disorder (PTSD) is a chronic mental illness triggered by traumatic experiences such as wars, natural disasters, or catastrophes, and it characterized anxiety, depression cognitive impairment. Diosgenin steroidal sapogenin with known neuroprotective antioxidant properties. This study aimed to assess the pharmacological potential of diosgenin in single prolonged (SPS) model PTSD, plus other behavioral models along any consequent alterations brain neurochemistry male mice. Methodology: SPS was induced restraining animals for 2 h, followed 20 min forced swim, recuperation 15 min, finally, exposure ether induce anesthesia. The SPS-exposed were treated (20, 40, 60 mg/kg) compared positive controls, fluoxetine donepezil, then they observed changes anxiety/depression-like behaviors, After screening, postmortem serotonin, noradrenaline, dopamine, vitamin C, adenosine its metabolites inosine hypoxanthine quantified frontal cortex, hippocampus, striatum high-performance liquid chromatography. Additionally, animal serum screened corticosterone levels. Results: results showed that reversed anxiety- depression-like ameliorated impairment dose-dependent manner. restored monoamine C levels dose-dependently modulated regions. also reinstated otherwise increased Conclusion: findings suggest may be candidate improving symptoms PTSD.

Язык: Английский

Процитировано

9