The Effects of Probiotics, Prebiotics and Synbiotics in Non-Alcoholic Fat Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(15), С. 8805 - 8805

Опубликована: Авг. 8, 2022

Modifications in the microbiota caused by environmental and genetic reasons can unbalance intestinal homeostasis, deregulating host's metabolism immune system, intensifying risk factors for development aggravation of non-alcoholic fat liver disease (NAFLD). The use probiotics, prebiotics synbiotics have been considered a potential promising strategy to regulate gut produce beneficial effects patients with conditions. For this reason, review aimed evaluate effectiveness prebiotics, symbiotics NAFLD NASH. Pubmed, Embase, Cochrane databases were consulted, PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analysis) guidelines followed. clinical trials used study demonstrated that interventions could improve wide range markers inflammation, glycemia, insulin resistance, dyslipidemia, obesity, injury (decrease hepatic enzymes steatosis fibrosis). Although modulators do not play healing role, they work as an important adjunct therapy pathological processes involving its spectrums, either improving barrier or preventing formation toxic metabolites acting on system.

Язык: Английский

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Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives

Microorganisms, Год журнала: 2024, Номер 12(3), С. 430 - 430

Опубликована: Фев. 20, 2024

Next-generation probiotics (NGPs) represent an innovative group of beneficial bacteria that are currently undergoing research and development. NGPs designed not only for conventional use as foods or dietary supplements but also tailored pharmaceutical applications. Research indicates show therapeutic promise in addressing various chronic ailments. Offering multiple advantages over probiotics, present opportunities personalized probiotic therapies, involvement synthetic biology gene editing, participation combination targeted delivery methods, application settings. Our review discusses the potential effect NGPs, covering diverse trajectories including their identification, characterization, delivery. Furthermore, this elucidates influence on critical aspects human health, specifically, gut immune function, broader health outcomes. Mechanistic insights encompass production bioactive compounds, competitive interactions with pathogenic bacteria, modulation cell activity, reinforcement barrier. What is noteworthy current points out prevalent NGP strains sources, providing a highlight comprehensive framework understanding applications future benefits domain advanced therapeutics.

Язык: Английский

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Gut Microbiota Dysbiosis, Oxidative Stress, Inflammation, and Epigenetic Alterations in Metabolic Diseases

Antioxidants, Год журнала: 2024, Номер 13(8), С. 985 - 985

Опубликована: Авг. 14, 2024

Gut dysbiosis, resulting from an imbalance in the gut microbiome, can induce excessive production of reactive oxygen species (ROS), leading to inflammation, DNA damage, activation immune system, and epigenetic alterations critical genes involved metabolic pathways. dysbiosis-induced inflammation also disrupt barrier integrity increase intestinal permeability, which allows gut-derived toxic products enter liver systemic circulation, further triggering oxidative stress, associated with diseases. However, specific metabolites, such as short-chain fatty acids (SCFAs), lactate, vitamins, modulate stress system through mechanisms, thereby improving function. microbiota diet-induced diseases, obesity, insulin resistance, dyslipidemia, hypertension, transfer next generation, involving mechanisms. In this review, we will introduce key that, along dysbiosis ROS, are engaged developing Finally, discuss potential therapeutic interventions dietary modifications, prebiotics, probiotics, postbiotics, fecal transplantation, may reduce syndrome by altering alterations. summary, review highlights crucial role pathogenesis a particular focus on (including histone methylomics, RNA interference) that prevent or improve

Язык: Английский

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Metabolic memory: mechanisms and diseases

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 28, 2024

Metabolic diseases and their complications impose health economic burdens worldwide. Evidence from past experimental studies clinical trials suggests our body may have the ability to remember metabolic environment, such as hyperglycemia or hyperlipidemia, thus leading chronic inflammatory disorders other even after elimination of these environments. The long-term effects that aberrant metabolism on been summarized memory are found assume a crucial role in states disease. Multiple molecular mechanisms collectively participate management, resulting different cellular alterations well tissue organ dysfunctions, culminating disease progression affecting offspring. elucidation expansion concept provides more comprehensive insight into pathogenic underlying promises be new target detection management. Here, we retrace history relevant research summarize its salient characteristics. We provide detailed discussion by which involved development at molecular, cellular, levels, with emphasis impact epigenetic modulations. Finally, present some pivotal findings arguing favor targeting develop therapeutic strategies for latest reflections consequences implications human diseases.

Язык: Английский

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Modulation of immunity by tryptophan microbial metabolites

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Июнь 21, 2023

Tryptophan (Trp) is an essential amino acid that can be metabolized via endogenous and exogenous pathways, including the Kynurenine Pathway, 5-Hydroxyindole Pathway (also Serotonin pathway), Microbial pathway. Of these, Trp metabolic pathways in gut have recently been extensively studied for their production of bioactive molecules. The microbiota plays important role host metabolism immunity, microbial metabolites influence development progression various diseases, inflammatory, cardiovascular neurological cancer, by mediating body’s immunity. This review briefly outlines crosstalk between microorganisms body, starting from three Trp. mechanisms which act on organism immunity are summarized, potential implications disease prevention treatment highlighted.

Язык: Английский

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Short-chain fatty acids in nonalcoholic fatty liver disease: New prospects for short-chain fatty acids as therapeutic targets

Heliyon, Год журнала: 2024, Номер 10(5), С. e26991 - e26991

Опубликована: Фев. 27, 2024

Nonalcoholic fatty liver disease (NAFLD) is a stress-induced injury related to heredity, environmental exposure and the gut microbiome metabolism. Short-chain acids (SCFAs), metabolites of microbiota (GM), participate in regulation hepatic steatosis inflammation through gut-liver axis, which play an important role alleviation NAFLD. However, little progress has been made systematically elucidating mechanism how SCFAs improve NAFLD, especially epigenetic mechanisms potential therapeutic application as clinical treatment for Herein, we adopted PubMed Medline search relevant keywords such 'SCFAs', 'NAFLD', 'gut microbiota', 'Epigenetic', 'diet', 'prebiotic effect' review latest research on NAFLD up November 2023. In this review, firstly, specifically discussed production function SCFAs, well their crosstalk coordination axis. Secondly, provided updated summary intensive discussion affect alleviate from perspective genetic epigenetic. Thirdly, paid attention pharmacological physiological characteristics proposed promising future direction adopt alone or combination with prebiotics drugs prevent treat Together, aimed elucidate provide new insights prospects target

Язык: Английский

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Personalizing Nutrition Strategies: Bridging Research and Public Health

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(3), С. 305 - 305

Опубликована: Март 13, 2024

In recent years, although life expectancy has increased significantly, non-communicable diseases (NCDs) continue to pose a significant threat the health of global population. Therefore, eating habits have been recognized as key modifiable factors that influence people’s and well-being. For this reason, it is interesting study dietary patterns, since human diet complex mixture macronutrients, micronutrients, bioactive compounds, can modulate multiple physiological processes, including immune function, metabolism, inflammation. To ensure data we acquired were current relevant, searched primary secondary sources, scientific journals, bibliographic indexes, databases in last 15 years with most relevant articles. After search, observed all research on NCDs suggests critical factor shaping an individual’s outcomes. Thus, cardiovascular, metabolic, mental, dental, visual depends largely intake, nutritional behaviors. A high processed refined foods, added sugars, saturated fats increase risk developing chronic diseases. On other hand, rich whole, nutrient-dense such vegetables, fruits, nuts, legumes, adherence Mediterranean improve health’s people.

Язык: Английский

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Mechanism of Acupuncture in Treating Obesity: Advances and Prospects

The American Journal of Chinese Medicine, Год журнала: 2024, Номер 52(01), С. 1 - 33

Опубликована: Янв. 1, 2024

Obesity is a common metabolic syndrome that causes significant burden on individuals and society. Conventional therapies include lifestyle interventions, bariatric surgery, pharmacological therapies, which are not effective have high risk of adverse events. Acupuncture an alternative for obesity, it modulates the hypothalamus, sympathetic activity parasympathetic activity, obesity-related hormones (leptin, ghrelin, insulin, CCK), brain-gut axis, inflammatory status, adipose tissue browning, muscle blood flow, hypoxia, reactive oxygen species (ROS) to influence metabolism, eating behavior, motivation, cognition, reward system. However, hypothalamic regulation by acupuncture should be further demonstrated in human studies using novel techniques, such as functional MRI (fMRI), positron emission tomography (PET), electroencephalogram (EEG), magnetoencephalography (MEG). Moreover, longer follow-up phase clinical trials required detect long-term effects acupuncture. Also, future investigate optimal therapeutic option obesity. This review aims consolidate recent improvements mechanism obesity well discuss research prospects potential

Язык: Английский

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The Gut Microbial Regulation of Epigenetic Modification from a Metabolic Perspective

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7175 - 7175

Опубликована: Июнь 29, 2024

Obesity is a global health challenge that has received increasing attention in contemporary research. The gut microbiota been implicated the development of obesity, primarily through its involvement regulating various host metabolic processes. Recent research suggests epigenetic modifications may serve as crucial pathways which and metabolites contribute to pathogenesis obesity other disorders. Hence, understanding interplay between mechanisms for elucidating impact on host. This review focuses relationship with several obesity-related pathogenic mechanisms, including energy dysregulation, inflammation, maternal inheritance. These findings could novel therapeutic targets probiotics, prebiotics, fecal transplantation tools treating disruptions. It also aid developing strategies modulate microbiota, thereby characteristics obesity.

Язык: Английский

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The effect of gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review and network meta-analysis

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 6, 2025

The incidence of NAFLD is increasing. Preclinical evidences indicate that modulation the gut microbiome could be a promising target in nonalcoholic fatty liver disease. A systematic review and network meta-analysis was conducted to compare effect probiotics, synbiotics, prebiotics, fecal microbiota transplant, antibiotics on liver-enzyme, metabolic effects liver-specific patients with NAFLD. randomized controlled trails (RCTs), limited English language were searched from database such as Pubmed, Embase, Web science Cochrane Library inception November 2024. Review Manager 5.3 used draw bias risk. Inconsistency test publication-bias assessed by Stata 14.0. Random model assemble direct indirect evidences. intervention presented mean differences 95% confidence interval. total 1921 37 RCTs eventually included our study. 23 evaluated 10 4 3 FMT one RCT antibiotics. Probiotics synbiotics associated significantly reduction alanine aminotransferase [ALT, (MD: -5.09; 95%CI: -9.79, -0.39), -7.38, 95CI%: -11.94, -2.82)] stiffness measurement elastograph [LSM, -0.37;95%CI: -0.49, -0.25), -1.00;95%CI: -1.59, -0.41)]. In addition to, superior probiotics reducing LSM. Synbiotics significant Controlled Attenuation Parameter [CAP, -39.34; -74.73, -3.95)]. Both aspartate transaminase [AST, -7.81; -15.49, -0.12), -13.32; -23, -3.64)]. Allogenic Homeostatic Model Assessment for Insulin Resistance [HOMA-IR, -0.7, -1.26, -0.15), -1.8, -3.53, - 0.07)]. body mass index [BMI, MD: -1.84, -3.35, -0.33]. supplement maybe way improve LSM, steatosis More trials are needed determine efficacy And adverse events MTTs should further explored. https://www.crd.york.ac.uk/prospero/, CRD42023450093.

Язык: Английский

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