World Journal of Cardiology,
Год журнала:
2025,
Номер
17(2)
Опубликована: Фев. 24, 2025
Metabolic
diseases
have
emerged
as
a
leading
cause
of
mortality
from
non-communicable
diseases,
posing
significant
global
public
health
challenge.
Although
the
association
between
ceramides
(Cers)
and
metabolic
is
well-established,
role
acid
sphingomyelinase
(ASMase)/Cer
pathway
in
these
remains
underexplored.
This
review
synthesizes
recent
research
on
biological
functions,
regulatory
mechanisms,
targeted
therapies
related
to
ASMase/Cer
conditions,
including
obesity,
diabetes,
non-alcoholic
fatty
liver
disease,
cardiovascular
disease.
The
effects
disease-related
indicators,
such
glycolipid
metabolism,
insulin
resistance,
inflammation,
mitochondrial
homeostasis
are
elucidated.
Moreover,
this
article
discusses
therapeutic
strategies
using
inhibitors
for
inverse
prevention
treatment
light
possible
efficacy
blockade
arresting
progression
diseases.
These
insights
offered
herein
should
provide
insight
into
contribution
offer
tools
develop
interventions
pathologies
their
severe
complications.
Journal of Fungi,
Год журнала:
2024,
Номер
10(9), С. 648 - 648
Опубликована: Сен. 13, 2024
Secondary
metabolism
is
one
of
the
important
mechanisms
by
which
fungi
adapt
to
their
living
environment
and
promote
survival
reproduction.
Recent
studies
have
shown
that
epigenetic
regulation,
such
as
DNA
methylation,
histone
modifications,
non-coding
RNAs,
plays
key
roles
in
fungal
secondary
affect
growth,
survival,
pathogenicity.
This
review
describes
recent
advances
study
regulation
metabolism.
We
discuss
way
markers
respond
environmental
changes
stimulate
production
biologically
active
compounds
fungi,
feasibility
these
new
findings
applied
develop
antifungal
strategies
optimize
In
addition,
we
deliberated
on
possible
future
directions
research
this
field.
A
deeper
understanding
regulatory
networks
a
focus
for
research.
Toxics,
Год журнала:
2022,
Номер
10(10), С. 579 - 579
Опубликована: Сен. 30, 2022
Recently,
growing
attention
has
focused
on
the
impact
of
air
pollution
gut
microbiota
as
a
possible
mechanism
by
which
pollutant
exposure
increased
risk
for
chronic
diseases,
evidenced
in
vivo
studies
demonstrating
important
exposure-induced
alterations
diversity
and
relative
abundance
bacterial
taxa.
This
systematic
review
provides
updated
state-of-art
findings
examining
human
microbiota.
Databases
PubMed,
Scopus,
Web
Science
were
searched
with
following
strategy:
“air
poll*”
AND
“gut
micro*”
OR
“intestinal
micro*”;
moreover,
total
10
included.
Overall,
there
is
evidence
that
short-term
long-term
to
pollutants
have
potential
alter
composition
microbiota;
some
also
correlated
adverse
health
effects
(impaired
fasting
glucose,
pregnancy
outcomes,
asthma
attacks)
via
and/or
function
However,
this
topic
still
scarce,
large
cohort
are
needed
globally.
World Journal of Cardiology,
Год журнала:
2025,
Номер
17(2)
Опубликована: Фев. 24, 2025
Metabolic
diseases
have
emerged
as
a
leading
cause
of
mortality
from
non-communicable
diseases,
posing
significant
global
public
health
challenge.
Although
the
association
between
ceramides
(Cers)
and
metabolic
is
well-established,
role
acid
sphingomyelinase
(ASMase)/Cer
pathway
in
these
remains
underexplored.
This
review
synthesizes
recent
research
on
biological
functions,
regulatory
mechanisms,
targeted
therapies
related
to
ASMase/Cer
conditions,
including
obesity,
diabetes,
non-alcoholic
fatty
liver
disease,
cardiovascular
disease.
The
effects
disease-related
indicators,
such
glycolipid
metabolism,
insulin
resistance,
inflammation,
mitochondrial
homeostasis
are
elucidated.
Moreover,
this
article
discusses
therapeutic
strategies
using
inhibitors
for
inverse
prevention
treatment
light
possible
efficacy
blockade
arresting
progression
diseases.
These
insights
offered
herein
should
provide
insight
into
contribution
offer
tools
develop
interventions
pathologies
their
severe
complications.
