Differences in Fatty Acid Metabolism between MCDD and HFD Induced Metabolic Dysfunction-associated Fatty Liver Disease Model Mice DOI Creative Commons
Jiaxuan Wang, Xinzhu Liu, Zhen Guo

и другие.

Biological Procedures Online, Год журнала: 2025, Номер 27(1)

Опубликована: Апрель 14, 2025

The global incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing annually, which has become a major public-health concern. MAFLD typically associated with obesity, hyperlipemia, or syndrome. Dietary induction one the most common methods for preparing animal models MAFLD. However, there are phenotypic differences between methionine-choline-deficient diet (MCDD) and high fat (HFD) models. To explore in hepatic acid metabolism MCDD HFD induced MAFLD, we analyzed serum tissue from two We found that accumulation function damage were pathological features both Furthermore, model, expression transport proteins increased, while efflux mRNA decreased, along decrease blood lipid levels. In uptake proteins, an increase Impaired oxidation increased play key roles pathogenesis inverse changes de novo lipogenesis may represent important mechanism leads to

Язык: Английский

Mitochondrial Quality Control: Its Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) DOI Creative Commons
Soyeon Shin, Jaeyoung Kim, Ju‐Yeun Lee

и другие.

Journal of Obesity & Metabolic Syndrome, Год журнала: 2023, Номер 32(4), С. 289 - 302

Опубликована: Дек. 5, 2023

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty disease, is characterized by hepatic steatosis and metabolic dysfunction often associated with obesity insulin resistance. Recent research indicates a rapid escalation in MASLD cases, projections suggesting doubling the United States 2030. This review focuses on central role of mitochondria pathogenesis explores potential therapeutic interventions. Mitochondria are dynamic organelles that orchestrate energy production metabolism critically involved MASLD. Dysfunctional contribute to lipid accumulation, inflammation, fibrosis. Genetic associations further underscore relationship between mitochondrial dynamics susceptibility. Although U.S. Food Drug Administration-approved treatments for remain elusive, ongoing clinical trials have highlighted promising strategies target dysfunction, including vitamin E, metformin, glucagon-like peptide-1 receptor agonists. In preclinical studies, novel therapeutics, nicotinamide adenine dinucleotide

Язык: Английский

Процитировано

27
Association between TyG index trajectory and new-onset lean NAFLD: a longitudinal study DOI Creative Commons
Haoshuang Liu, Jingfeng Chen, Qian Qin

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Фев. 27, 2024

Objective The purpose of this manuscript is to identify longitudinal trajectories changes in triglyceride glucose (TyG) index and investigate the association TyG with risk lean nonalcoholic fatty liver disease (NAFLD). Methods Using data from 1,109 participants Health Management Cohort study, we used Latent Class Growth Modeling (LCGM) develop trajectories. a Cox proportional hazard model, relationship between incident NAFLD was analyzed. Restricted cubic splines (RCS) were visually display dose-response NAFLD. We also deployed machine learning (ML) via Light Gradient Boosting Machine (LightGBM) predict NAFLD, validated by receiver operating characteristic curves (ROCs). LightGBM model create an online tool for medical use. In addition, assessed abdominal ultrasound after excluding other fat causes. Results median age population 46.6 years, 440 (39.68%) men. Three distinct identified: “low stable” (TyG ranged 7.66 7.71, n=206, 18.5%), “moderate 8.11 8.15, n=542, 48.8%), “high 8.61 8.67, n=363, 32.7%). trajectory as reference, associated increased lean-NAFLD ( HR : 2.668, 95% CI 1.098-6.484). After adjusting baseline age, WC, SBP, BMI, ALT, slightly 1.767 :0.730-4.275) 2.668 :1.098-6.484), respectively. RCS analysis showed significant nonlinear χ 2 = 11.5, P =0.003). demonstrated high accuracy (Train AUC 0.870, Test 0.766). An based on our developed assist clinicians assessing risk. Conclusion serves promising noninvasive marker implications clinical practice public health policy.

Язык: Английский

Процитировано

10
Early and accurate diagnosis of steatotic liver by artificial intelligence (AI)-supported ultrasonography DOI
Sérgio Santoro, Mohamad Khalil,

Hala Abdallah

и другие.

European Journal of Internal Medicine, Год журнала: 2024, Номер 125, С. 57 - 66

Опубликована: Март 14, 2024

Язык: Английский

Процитировано

10
Lean or diabetic subtypes predict increased all-cause and disease-specific mortality in metabolic-associated fatty liver disease DOI Creative Commons
Goh Eun Chung, Su Jong Yu, Jeong‐Ju Yoo

и другие.

BMC Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Янв. 4, 2023

Abstract Background Metabolic-associated fatty liver disease (MAFLD) encompasses diverse groups with potentially heterogeneous clinical outcomes. We investigated the risk of all-cause and disease-specific mortality in MAFLD subgroups. Methods Using Korean National Health Insurance Service database, participants were divided into four subgroups: no MAFLD, MAFLD-diabetes, MAFLD-overweight/obese, MAFLD-lean. Hazard ratios (HRs) 95% confidence interval (CI) values for according to subgroups analyzed using Cox proportional hazards models. Results Among 9,935,314 participants, those MAFLD-diabetes showed highest mortality. The HRs (95% CI) 1.61 (1.59–1.63), 1.36 (1.34–1.38), 1.19 (1.18–1.20) MAFLD-lean, MAFLD-overweight/obese groups, respectively. magnitude cardiovascular cancer-related same pattern. liver-related MAFLD-lean group (HR: 2.84, CI: 2.72–2.97) was comparable that 2.85, 2.75–2.95). When stratified by body mass index, individuals underweight (HR, 5.03, 4.23–5.97). Conclusions had a higher than did group. Classifying based on metabolic phenotypes might help stratification patients MAFLD.

Язык: Английский

Процитировано

18
Inflammatory Bowel Disease Is an Independent Risk Factor for Metabolic Dysfunction–Associated Steatotic Liver Disease in Lean Individuals DOI Creative Commons
Samuel J. Martínez‐Domínguez, Sandra G. García, Carla J. Gargallo-Puyuelo

и другие.

Inflammatory Bowel Diseases, Год журнала: 2023, Номер unknown

Опубликована: Авг. 22, 2023

Abstract Background Despite classical association between metabolic dysfunction–associated steatotic liver disease (MASLD) and obesity, there is increasing evidence on the development of MASLD in lean individuals. The aim study was to assess prevalence risk factors significant fibrosis participants with inflammatory bowel (IBD). Methods This a cross-sectional, case-control including 300 cases IBD 80 controls without IBD, matched by sex age. All underwent ultrasound, transient elastography, laboratory tests. Results group showed significantly higher compared non-IBD (21.3% vs 10%; P = .022), but no differences were observed (4.7% 0.0%; 1.000). No found who overweight/obese (66.8% 70.8%; .442). In addition, (P < .001). an independent factor for (odds ratio [OR], 2.71; 95% confidence interval [CI], 1.05-7.01; .04), after adjusting classic prior history systemic steroid use. Nevertheless, related identified participants. When groups compared, levels homeostatic model assessment insulin resistance (OR, 1.49; CI, 1.11-1.98; .007) smoking 4.66; 1.17-18.49; .029). Conclusions group, factors.

Язык: Английский

Процитировано

18
Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus DOI Open Access
Karina Sato-Espinoza,

Perapa Chotiprasidhi,

Mariella R. Huamán

и другие.

World Journal of Hepatology, Год журнала: 2024, Номер 16(3), С. 452 - 464

Опубликована: Март 27, 2024

BACKGROUND The prevalence of metabolic-associated fatty liver disease (MAFLD) is a growing public health issue in people living with human immunodeficiency virus (PLWH). However, the pathophysiology MAFLD still unknown, and role genetic variables only now becoming evident. AIM To evaluate associations gene-polymorphism-related PLWH. METHODS study employed transient elastography controlled attenuation parameter ≥ 248 dB/m to identify patients from Super Tertiary Hospital central Thailand. Candidate single-nucleotide polymorphisms (SNPs) were genotyped using TaqMan® MGB probe 5' nuclease assays for seven MAFLD-related genes. Statistical analyses included SNP frequency analysis, Fisher's Exact Chi-square tests, odds ratio calculations, multivariable logistic regression. RESULTS G-allele carriers PNPLA3 (rs738409) exhibited two-fold rise MAFLD, increasing by 2.5 times infection. clinical features patterns imply that LEP rs7799039 A-allele had nine (P = 0.001) more significant chance developing aberrant triglyceride among CONCLUSION current shows an association between rs738409

Язык: Английский

Процитировано

9
Association between weight-adjusted waist index and non-alcoholic fatty liver disease: a population-based study DOI Creative Commons

Changhui Yu,

Shiming He,

Maobin Kuang

и другие.

BMC Endocrine Disorders, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 18, 2024

Abstract Background Obesity is the most important driver of non-alcoholic fatty liver disease (NAFLD); nevertheless, relationship weight-adjusted waist index (WWI), a new obesity index, with NAFLD unclear. Methods This retrospective study used data from NAGALA project 1994 to 2016. WWI values were calculated using circumference (WC) and weight measurements participants. Three stepwise adjusted logistic regression models developed assess in whole population both sexes. Additionally, we also conducted series exploratory analysis test potential impact body mass (BMI), age, smoking status exercise habits on association NAFLD. Receiver operating characteristic (ROC) curves estimate cut-off points for identifying entire Results The current included 11,805 individuals who participated health screenings, including 6,451 men 5,354 women. After adjusting all non-collinear variables multivariable model, found significant positive correlation For each unit increase WWI, risk increased by 72% population, 84% men, 63% Furthermore, subgroup analyses revealed no discrepancies across varying ages, habits, (all P -interaction > 0.05), except different BMI groups ( < 0.05). Specifically, compared overweight/obese group, was significantly stronger non-obese especially men. Finally, based results ROC analysis, determined that point identify 9.7675 9.9987 Conclusions first establish between Moreover, assessing influence without may yield more valuable insights those are overweight or obese.

Язык: Английский

Процитировано

7
The relationship between serum uric acid level and non-alcoholic fatty liver disease in northern China: a retrospective cohort study DOI Creative Commons
Qianjun He, Xinyue Liu, Guoyong Ding

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 21, 2025

Язык: Английский

Процитировано

1
Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes DOI Open Access
Teresa Salvatore, Raffaele Galiero, Alfredo Caturano

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 24(1), С. 658 - 658

Опубликована: Дек. 30, 2022

Since early times, being overweight and obesity have been associated with impaired glucose metabolism type 2 diabetes (T2D). Similarly, a less frequent adult-onset in low body mass index (BMI) people has known for many decades. This form is mainly found developing countries, whereby the largest increase incidence expected coming years. The number of non-obese patients T2D also on rise among non-white ethnic minorities living high-income Western countries due to growing migratory flows. A great deal energy spent understanding mechanisms that bind T2D. Conversely, pathophysiologic features factors driving risk development are still much debated. To reduce global burden diabetes, we need understand why not all obese develop those obese. Moreover, through both an effective prevention implementation individualized clinical management it hoped this will help burden. purpose review take stock current knowledge about pathophysiology highlight which aspects worthy future studies.

Язык: Английский

Процитировано

25
Discovery of the First-in-Class Intestinal Restricted FXR and FABP1 Dual Modulator ZLY28 for the Treatment of Nonalcoholic Fatty Liver Disease DOI
Qiang Ren, Ya Chen,

Zongtao Zhou

и другие.

Journal of Medicinal Chemistry, Год журнала: 2023, Номер 66(9), С. 6082 - 6104

Опубликована: Апрель 20, 2023

The prevalence of nonalcoholic steatohepatitis (NASH) is increasing rapidly worldwide, and NASH has become a serious problem for human health. Recently, the selective activation intestinal farnesoid X receptor (FXR) was considered as more promising strategy treatment with lesser side effects due to reduced systemic exposure. Moreover, inhibition fatty acid binding protein 1 (FABP1) alleviated obesity by reducing dietary uptake. In this study, first-in-class restricted FXR FABP1 dual-target modulator ZLY28 discovered comprehensive multiparameter optimization studies. exposure might provide better safety decreasing on- off-target in vivo. mice, exerted robust anti-NASH inhibiting activating FXR-FGF15 signaling pathway ileum. With above attractive efficacy preliminary profiles, worthy further evaluation novel agent.

Язык: Английский

Процитировано

14