Targeting Iron-Sulfur Clusters in Cancer: Opportunities and Challenges for Ferroptosis-Based Therapy

Cancers, Год журнала: 2023, Номер 15(10), С. 2694 - 2694

Опубликована: Май 10, 2023

Iron dysregulation is a hallmark of cancer, characterized by an overexpression genes involved in iron metabolism and iron-sulfur cluster (ISC) biogenesis. Dysregulated homeostasis increases intracellular labile iron, which may lead to the formation excess cytotoxic radicals make it vulnerable various types regulated cell death, including ferroptosis. The inhibition ISC synthesis triggers starvation response, increasing lipid peroxidation ferroptosis cancer cells treated with oxidative stress-inducing agents. Various methods, such as redox operations, chelation, replacement redox-inert metals, can destabilize or limit function, providing potential therapeutic strategies for treatment. Targeting ISCs induce represents promising approach therapy. This review summarizes state-of-the-art overview cells, role modulation ferroptosis, targeting induction Further research necessary develop validate these clinical trials cancers, ultimately development novel effective treatments patients.

Язык: Английский

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The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Journal of Inflammation Research, Год журнала: 2023, Номер Volume 16, С. 381 - 389

Опубликована: Янв. 1, 2023

Abstract: Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types death mechanisms, it exhibits distinct biological and morphological features characterized by the loss peroxidase repair activity caused glutathione 4, presence redox-active iron, oxidation phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays key role in various liver diseases such as alcoholic injury, non-alcoholic steatohepatitis, cirrhosis, cancer. However, mechanism its regulation on chronic disease are controversial among different cells liver. Herein, we summarize current disease, aiming to outline blueprint an effective option for therapy. Keywords: ferroptosis, iron metabolism, oxidative stress,

Язык: Английский

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Iron metabolism and ferroptosis in nonalcoholic fatty liver disease: what is our next step?

AJP Endocrinology and Metabolism, Год журнала: 2024, Номер 326(6), С. E767 - E775

Опубликована: Март 20, 2024

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic with increasing prevalence worldwide. NAFLD could develop from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), NASH-related fibrosis, cirrhosis, and even hepatocellular carcinoma. However, mechanism of development has not yet been fully defined. Recently, emerging evidence shows that dysregulated iron metabolism marked by elevated serum ferritin, ferroptosis are involved in NAFLD. Understanding can shed light on mechanisms development. Here, we summarized studies process highlight potential medications therapies for treating

Язык: Английский

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BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion

Cell Reports, Год журнала: 2024, Номер 43(7), С. 114403 - 114403

Опубликована: Июнь 27, 2024

Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation. A model system constructed to induce ferroptosis re-expressing the transcription factor BACH1, potent inducer, in immortalized mouse embryonic fibroblasts (iMEFs). The transfer culture supernatant from ferroptotic iMEFs activates proliferation hepatoma cells and other suppresses cellular senescence-like features. BACH1-dependent secretion longevity FGF21 increased iMEFs. anti-senescent effects these are abrogated Fgf21 knockout. BACH1 promoting stress increases protein expression suppressing its autophagic degradation through transcriptional Sqstm1 Lamp2 repression. BACH1-induced obesity high-fat diet-fed mice short lifespan progeria mice. inhibition aging-related phenotypes can be physiologically significant regarding ferroptosis.

Язык: Английский

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Targeting cell death in NAFLD: mechanisms and targeted therapies

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Сен. 7, 2024

Язык: Английский

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