Biocatalysis and Agricultural Biotechnology, Год журнала: 2023, Номер 53, С. 102874 - 102874
Опубликована: Окт. 1, 2023
Язык: Английский
Journal of Cellular and Molecular Medicine, Год журнала: 2023, Номер 27(6), С. 737 - 762
Опубликована: Фев. 24, 2023
Abstract In recent years, drug manufacturers and researchers have begun to consider the nanobiotechnology approach improve delivery system for tumour cancer diseases. this article, we review current strategies delivery, which mainly focuses on sustaining biocompatibility, biodistribution, active targeting. The conventional therapy using cornerstone drugs such as fludarabine, cisplatin etoposide, paclitaxel has its own challenges especially not being able discriminate between versus normal cells eventually led toxicity side effects in patients. contrast approach, nanoparticle‐based provides target‐specific controlled release of drug, a better therapeutic window treatment options by focusing eradication diseased via targeting sparing passive Additionally, tumours associated with brain is hampered impermeability blood–brain barriers drugs, poor survival Nanoparticle‐based offers superior target breaching barriers. Herein, provide an overview properties nanoparticles that are crucial nanotechnology applications. We address potential future applications specific or desired areas. particular, use nanomaterials, biostructures, methods targeted explored.
Язык: Английский
Процитировано
34
ACS Applied Bio Materials, Год журнала: 2023, Номер 6(10), С. 3959 - 3983
Опубликована: Сен. 12, 2023
Applications of nanotechnology have increased the importance research and nanocarriers, which revolutionized method drug delivery to treat several diseases, including cancer, in past few years. Cancer, one world's fatal has drawn scientists' attention for its multidrug resistance various chemotherapeutic drugs. To minimize side effects agents on healthy cells develop technological advancement systems, scientists developed an alternative approach delivering drugs at targeted site by integrating it inside nanocarriers like synthetic polymers, nanotubes, micelles, dendrimers, magnetic nanoparticles, quantum dots (QDs), lipid nano-biopolymeric substances, etc., shown promising results both preclinical clinical trials cancer management. Besides that, especially biopolymeric received much from researchers due their cost-effectiveness, biodegradability, treatment efficacy, ability target crossing blood-brain barrier. This review emphasizes fabrication processes, therapeutic theragnostic applications, different targeting vitro vivo, conclude with challenges opportunities future exploration using onco-therapy improved availability reduced toxicity.
Язык: Английский
Процитировано
29
Sustainability, Год журнала: 2023, Номер 15(20), С. 14792 - 14792
Опубликована: Окт. 12, 2023
Drought stress threatens global food security and requires creative agricultural solutions. Recently, phyto-synthesized nanoparticles NPs have garnered attention as a way to reduce crop drought. This extensive research examines how improve growth biochemistry in drought-stressed situations. The review begins with an introduction highlighting the urgency of addressing challenges posed by It also highlights significance synthesized from photosynthesis this context. Its purpose is underscore importance sustainable farming practices. approach contrasted conventional methods, elucidating ecological economic advantages NPs. discusses nanoparticles, including titanium dioxide, iron oxide, gold, silver, copper. In addition, we their ability enhance resistance. primary focus elucidate effects on plant development under drought stress. Noteworthy outcomes encompass improvements seed germination, seedling growth, water absorption, photosynthesis, chlorophyll content, activation antioxidant defense mechanisms, modulation hormonal responses. These results potential agents for enhancing mitigating assesses risks using agriculture. Considerations include non-target organisms, soil, environmental impacts. Further needed determine long-term effects, dangers, benefits Nanoparticles offer targeted improving tolerance, outpacing traditional methods ethics balance. Their mechanisms range nutrient delivery molecular regulation. However, impact remains understudied. critical identifying gaps advancing practices amid scarcity.
Язык: Английский
Процитировано
26
Environmental Research, Год журнала: 2023, Номер 231, С. 116148 - 116148
Опубликована: Май 20, 2023
Язык: Английский
Процитировано
24
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(4), С. 1946 - 1965
Опубликована: Март 1, 2024
Various nanomaterials have recently become fascinating tools in cancer diagnostic applications because of their multifunctional and inherent molecular characteristics that support efficient diagnosis image-guided therapy. Zein nanoparticles are a protein derived from maize. It belongs to the class prolamins possessing spherical structure with conformational properties similar those conventional globular proteins like ribonuclease insulin. gained massive interest over past couple years owing natural hydrophilicity, ease functionalization, biodegradability, biocompatibility, thereby improving oral bioavailability, nanoparticle targeting, prolonged drug administration. Thus, zein becoming promising candidate for precision delivery. This review highlights clinical significance applying nanosystems theragnostic─moreover, role delivery, anticancer agents, gene Finally, difficulties potential uses these NPs treatment detection discussed. will pave way researchers develop theranostic strategies medicine utilizing nanosystems.
Язык: Английский
Процитировано
15
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 96, С. 105689 - 105689
Опубликована: Апрель 21, 2024
In the last few years, wound healing and development of "ideal" biomaterials that provide quick recovery minimize scarring have represented one most important priorities researchers. this direction, silk fibroin (SF) scaffolds gained substantial awareness, as a promising polymer owing to their increased biocompatibility, outstanding mechanical properties, biodegradability, especially tensile strength. Furthermore, SF is acknowledged accelerate process by encouraging cell growth proliferation, also migration different types cells are included in stages process. Therefore, metal oxide nanoparticles (NPs), such iron (FeO), copper (CuO), zinc (ZnO), or magnesium (MgO) NPs, been extensively researched for antimicrobial properties ability enhance tissue regeneration addition SF. When introduced within scaffolds, these NPs impart enhanced including improved scaffold stability durability. Moreover, presence could increase biocompatibility facilitating adhesion, migration, ultimately promoting processes. The incorporation other natural polymers into has thus emerged favorable method therapeutic potential developed biomaterial. This review aims an overview advancements containing applications.
Язык: Английский
Процитировано
14
Environmental science and engineering, Год журнала: 2024, Номер unknown, С. 13 - 43
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
12
Plants, Год журнала: 2024, Номер 13(2), С. 313 - 313
Опубликована: Янв. 20, 2024
Plants, as sessile organisms, uptake nutrients from the soil. Throughout their whole life cycle, they confront various external biotic and abiotic threats, encompassing harmful element toxicity, pathogen infection, herbivore attack, posing risks to plant growth production. Plants have evolved multifaceted mechanisms cope with exogenous stress. The defense hypothesis (EDH) theory elucidates that plants employ elements within tissues withstand natural enemies. Notably, essential non-essential trace metals metalloids been identified active participants in mechanisms, especially nanoparticle form. In this review, we compiled synthetized recent advancements robust evidence regarding involvement of against stresses include stressors (such drought, salinity, heavy metal toxicity) environmental invasion attack). We discuss underlying involved enhancement physiological, biochemical, molecular perspectives. By consolidating information, review enhances our understanding how contribute defense. Drawing on current advances elemental defense, propose an application prospect agricultural products solve issues, including soil pollution production, for sustainable development agriculture. Although studies focused advanced, precise mechanism under response still needs further investigation.
Язык: Английский
Процитировано
12
Food Chemistry Advances, Год журнала: 2024, Номер 4, С. 100680 - 100680
Опубликована: Май 22, 2024
Green-synthesised silver nanoparticles (AgNP) used to treat antibiotic-resistant bacteria. This article addresses the synthesis and characterization of based on Acacia nilotica plant extract, as well their antibacterial efficacy against human illnesses. The information homogeneous, spherical shaped AgNP with an average size 23.65 nm was confirmed by XRD, SEM, EDAX, TEM, UV-Vis spectroscopy, FTIR analysis. effectiveness produced various bacteria tested using MIC zone inhibition experiments, showing impressive inhibitory effects. These findings imply that environmentally friendly production method potent properties biosynthesized hold promise for upcoming bio-related uses.
Язык: Английский
Процитировано
8
Frontiers in Plant Science, Год журнала: 2025, Номер 15
Опубликована: Янв. 17, 2025
Ensuring global food security and achieving sustainable agricultural productivity remains one of the foremost challenges contemporary era. The increasing impacts climate change environmental stressors like drought, salinity, heavy metal (HM) toxicity threaten crop worldwide. Addressing these demands development innovative technologies that can increase production, reduce impacts, bolster resilience agroecosystems against variation. Nanotechnology, particularly application nanoparticles (NPs), represents an approach to strengthen enhance sustainability agriculture. NPs have special physicochemical properties, including a high surface-area-to-volume ratio ability penetrate plant tissues, which enhances nutrient uptake, stress resistance, photosynthetic efficiency. This review paper explores how abiotic impact crops role in bolstering resistance challenges. main emphasis is on potential boost tolerance by triggering defense mechanisms, improving growth under stress, yield. demonstrated addressing key challenges, such as leaching, declining soil fertility, reduced yield due poor water management. However, applying must consider regulatory concerns, accumulation, non-target organisms, consumer perceptions NP-enhanced products. To mitigate land should be integrated with precision agriculture technologies, allowing targeted nano-fertilizers nano-pesticides. Although further research necessary assess their advantages address present promising cost-effective for enhancing future.
Язык: Английский
Процитировано
1