Enhancing antitumor immunity: the role of immune checkpoint inhibitors, anti-angiogenic therapy, and macrophage reprogramming

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 7, 2025

Cancer treatment has long been hindered by the complexity of tumor microenvironment (TME) and mechanisms that tumors employ to evade immune detection. Recently, combination checkpoint inhibitors (ICIs) anti-angiogenic therapies emerged as a promising approach improve cancer outcomes. This review delves into role immunostimulatory molecules ICIs in enhancing anti-tumor immunity, while also discussing therapeutic potential strategies cancer. In particular, we highlight critical endoplasmic reticulum (ER) stress angiogenesis. Moreover, explore macrophage reprogramming bolster with focus on restoring phagocytic function, modulating hypoxic environments, targeting cytokines chemokines shape responses. By examining underlying combining therapies, recent clinical trials discuss biomarkers guide predict efficacy.

Язык: Английский

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Interventions in cytokine signaling: novel horizons for psoriasis treatment

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 15, 2025

Intricate interactions between immune cells and cytokines define psoriasis, a chronic inflammatory skin condition that is immunological-mediated. Cytokines, including interleukins (ILs), interferons (IFNs), tumor necrosis factors (TNFs), chemokines, transforming growth factor-β (TGF-β), are essential for controlling cellular activity immunological responses, maintaining homeostasis contributing to the pathogenesis of psoriasis. These molecules modulate microenvironment by either promoting or suppressing inflammation, which significantly impacts therapeutic outcomes. Recent research indicates treatment strategies targeting chemokines have significant potential, offering new approaches regulating system, inhibiting progression reducing adverse effects traditional therapies. This review consolidates current knowledge on cytokine chemokine signaling pathways in psoriasis examines their significance treatment. Specific attention given like IL-17, IL-23, TNF-α, underscoring necessity innovative therapies these address processes. emphasizes principal part -pathological process explores challenges opportunities they present intervention. Furthermore, we examine recent advancements targeted therapies, with particular focus monoclonal antibodies, ongoing clinical trials.

Язык: Английский

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Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression

World Journal of Clinical Oncology, Год журнала: 2024, Номер 15(2), С. 195 - 207

Опубликована: Фев. 19, 2024

Interferon-gamma (IFN-γ) plays a dual role in cancer; it is both pro- and an antitumorigenic cytokine, depending on the type of cancer. The deregulation IFN-γ canonic pathway associated with several disorders, including vulnerability to viral infections, inflammation, cancer progression. In particular, interplay between lung adenocarcinoma (LUAD) infections appears exist association signaling. this mini-review, we investigated status signaling expression level its components LUAD. Interestingly, reduction

Язык: Английский

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Exercise accelerates recruitment of CD8+ T cell to promotes anti-tumor immunity in lung cancer via epinephrine

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Апрель 15, 2024

Abstract Background and purpose In recent years, there has been extensive research on the role of exercise as an adjunctive therapy for cancer. However, potential mechanisms underlying anti-tumor in lung cancer remain to be fully elucidated. As such, our study aims confirm whether exercise-induced elevation epinephrine can accelerate CD8 + T cell recruitment through modulation chemokines thus ultimately inhibit tumor progression. Method C57BL/6 mice were subcutaneously inoculated with Lewis cells (LLCs) establish a subcutaneous model. The randomly divided into different groups performed moderate-intensity program treadmill 5 consecutive days week, 45 min day. blood samples tissues collected after IHC, RT-qPCR, ELISA Western blot. addition, another group received daily treatment two weeks (0.05 mg/mL, 200 µL i.p.) (EPI, n = 8) replicate effects tumors vivo. treated concentrations (0, 5, 10, 20 µM) detect effect chemokine levels via RT-qPCR. Results This reveals that both pre- post-cancer effectively impede Exercise led increase EPI infiltration tumor. Exercise-induced is involved regulation Ccl5 Cxcl10 further leading enhanced inhibiting Conclusion training enhance immunity individuals. These findings will provide valuable insights future application clinical practice.

Язык: Английский

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S100A8/9 modulates perturbation and glycolysis of macrophages in allergic asthma mice

PeerJ, Год журнала: 2024, Номер 12, С. e17106 - e17106

Опубликована: Апрель 18, 2024

Allergic asthma is the most prevalent phenotype and associated with disorders of immune cells glycolysis. Macrophages are common type in lungs. Calprotectin (S100A8 S100A9) two pro-inflammatory molecules that target Toll-like receptor 4 (TLR4) substantially increased serum patients severe asthma. This study aimed to determine effects S100A8/A9 on macrophage polarization glycolysis allergic

Язык: Английский

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