JPRAS Open, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Cancers, Год журнала: 2025, Номер 17(6), С. 953 - 953
Опубликована: Март 12, 2025
The liver is the most common site of metastasis colorectal cancer (CRC), and one major causes CRC-related deaths worldwide. tumor microenvironment, particularly extracellular matrix (ECM), plays a critical role in CRC chemoresistance. Based on findings from clinical basic research, this review attempts to offer complete understanding ECM suggest potential ways for therapeutic intervention. First, ECMs’ regulating cell fate explored. We then discuss hepatic fingerprint its influence metastatic behavior cells, highlighting key molecular interactions that promote metastasis. In addition, we examine how changes within niche contribute chemoresistance, focusing remodeling by stiffening activation specific signaling pathways. Understanding these mechanisms crucial development novel strategies overcome improve outcomes patients.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 20, 2025
ETS-1, a key member of the Erythroblast Transformation-Specific (ETS) transcription factor family, plays an important role in cell biology and medical research due to its wide expression profile strong transcriptional regulation ability. It regulates fundamental biological processes, including proliferation, differentiation, apoptosis, is involved tumorigenesis metastasis, promoting malignant behaviors such as angiogenesis, matrix degradation, migration. Given association between ETS-1 overexpression aggressive characteristics multiple malignancies, it represents promising therapeutic target cancer treatment. This study aims systematically analyze within tumor immune microenvironment, elucidating mechanisms initiation, progression, metastasis. also investigates differential across tissues adjacent normal tissues, exploring potential molecular marker for diagnosis prognosis.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 21, 2025
Heart aging involves a complex interplay of genetic and environmental influences, leading to gradual deterioration cardiovascular integrity function. Age-related physiological changes, including ventricular hypertrophy, diastolic dysfunction, myocardial fibrosis, increased arterial stiffness, endothelial are influenced by key mechanisms like autophagy, inflammation, oxidative stress. This review aims explore the therapeutic potential plant-derived bioactive antioxidants in mitigating heart aging. These compounds, often rich polyphenols, flavonoids, other phytochemicals, exhibit notable antioxidant, anti-inflammatory, cardioprotective properties. substances have intricate properties, ability scavenge ROS, enhance endogenous antioxidant defenses, regulate signaling pathways, impede fibrosis inflammation-promoting processes. By focusing on molecular linked cardiac aging, produced from plants provide significant promise reduce age-related decline improve general health. Through comprehensive analysis preclinical clinical studies, this work highlights associated with promising effects antioxidants. The findings may helpful for researchers identifying specific molecules preventive heart.
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер unknown, С. 1 - 13
Опубликована: Апрель 10, 2025
This review aims to explore the research progress and application prospects of mesenchymal stem cells (MSCs) in treatment ischemic cardiomyopathy (ICM). ICM is a severe heart disease characterized by death myocardial due long-term ischemia, leading impaired function. MSCs have become one promising therapeutic methods for treating their unique anti-inflammatory, anti-apoptotic, immunomodulatory, pro-angiogenic properties. Studies shown that can improve function promoting neovascularization, reducing cell apoptosis, inhibiting inflammatory responses, regulating immune reactions. Additionally, be sourced from various tissues, including bone marrow, adipose tissue, umbilical cord/placenta, with different sources possessing distinct characteristics effects. Clinical studies indicated MSC therapy physical capacity left ventricular ejection fraction (LVEF) patients intractable angina, enhance perfusion overall infarction. However, issues such as mechanisms MSCs, optimal source, infusion routes, dose optimization still require further research. Future need address these transform clinical trials routine practice, thereby revolutionizing management prognosis ICM.
Язык: Английский
Процитировано
0
JPRAS Open, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0