Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 17, 2025
Melanoma
is
highly
invasive
and
resistant
to
conventional
treatments,
accounting
for
nearly
75%
of
skin
cancer-related
deaths
globally.
Traditional
therapies,
such
as
chemotherapy
immunotherapy,
often
exhibit
limited
efficacy
are
associated
with
significant
side
effects
due
systemic
drug
exposure.
Microneedles
(MNs),
an
emerging
delivery
system,
offer
multiple
advantages,
including
safety,
painlessness,
minimal
invasiveness,
controlled
release.
Among
these,
hydrogel
microneedles
(HMNs)
stand
out
their
extracellular
matrix-like
structure
swelling-induced
continuous
channels,
which
enable
the
direct
therapeutic
agents
into
tumor
microenvironment
(TME).
This
approach
enhances
bioavailability
while
reducing
toxicity,
establishing
HMNs
a
promising
platform
melanoma
treatment.
review
highlights
recent
advancements
in
therapy,
focusing
on
applications
biomarker
extraction
early
diagnosis
role
supporting
multimodal
treatment
strategies,
chemotherapy,
phototherapy,
targeted
combination
therapy.
Furthermore,
current
matrix
materials
fabrication
techniques
discussed.
Finally,
limitations
critically
analyzed,
recommendations
future
research
development
provided.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 18, 2025
Neoantigen-based
cancer
vaccine
therapy
represents
a
promising
precision
oncology
strategy
that
targets
unique
tumor-specific
mutations
to
elicit
robust
immune
response.
This
therapeutic
approach
is
designed
harness
the
host’s
response
against
neoantigens
eliminate
cells.
The
efficacy
of
neoantigen
vaccines
dependents
on
coordinated
action
diverse
cells,
including
T
lymphocytes,
dendritic
B
natural
killer
and
macrophages.
Each
cell
type
plays
distinct
crucial
role
in
recognizing,
targeting,
destroying
malignant
Understanding
mechanisms
governing
both
individual
collective
dynamics
for
success.
comprehensive
review
systematically
explores
neoantigen-specific
their
dynamic
interactions,
clinical
application
progress,
aiming
unveil
potential
value
future
development
treatment.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2923 - 2923
Опубликована: Март 24, 2025
Understanding
the
modulation
of
specific
immune
cells
within
tumor
microenvironment
(TME)
offers
new
hope
in
cancer
treatments,
especially
immunotherapies.
In
recent
years,
and
resistance
to
immunotherapy
have
become
critical
challenges
treatments.
However,
novel
strategies
for
emerged
as
promising
approaches
oncology
due
vital
roles
immunomodulators
regulating
progression
metastasis
modulating
immunological
responses
standard
care
With
progress
immuno-oncology,
a
growing
number
mechanisms
are
being
uncovered,
offering
potential
enhanced
clinical
near
future.
Thus,
gaining
comprehensive
understanding
broader
context
is
essential.
Herein,
we
particularly
summarize
paradoxical
role
tumor-related
cells,
focusing
on
how
targeted
their
actions
modulated
by
immunotherapies
overcome
immunotherapeutic
cells.
We
also
highlight
molecular
employed
tumors
evade
long-term
effects
agents,
rendering
them
ineffective.
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 456 - 456
Опубликована: Апрель 1, 2025
Advances
in
drug
delivery
systems
adapted
with
regenerative
medicine
have
transformed
healthcare
by
introducing
innovative
strategies
to
treat
(and
repair
many
instances)
disease-impacted
regions
of
the
human
body.
This
review
provides
a
comprehensive
analysis
latest
developments
and
challenges
integrating
technologies
medicine.
Recent
advances
technologies,
including
design
biomaterials,
localized
techniques,
controlled
release
guided
mathematical
models,
are
explored
illustrate
their
role
enhancing
therapeutic
precision
efficacy.
Additionally,
approaches
analyzed,
focus
on
extracellular
matrix
components,
stem
cell-based
therapies,
emerging
for
organ
regeneration
both
soft
hard
tissue
vitro
model
engineering.
In
particular,
also
discusses
applications
cellular
cells,
immune
endothelial
specialized
cells
such
as
chondrocytes
osteoblasts,
highlights
advancements
cell
methods
cell–cell
interaction
modulation.
addition,
future
directions
pivotal
trends
emphasizing
importance
interdisciplinary
collaboration
cutting-edge
innovations
provided
address
successful
outcomes
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 17, 2025
Melanoma
is
highly
invasive
and
resistant
to
conventional
treatments,
accounting
for
nearly
75%
of
skin
cancer-related
deaths
globally.
Traditional
therapies,
such
as
chemotherapy
immunotherapy,
often
exhibit
limited
efficacy
are
associated
with
significant
side
effects
due
systemic
drug
exposure.
Microneedles
(MNs),
an
emerging
delivery
system,
offer
multiple
advantages,
including
safety,
painlessness,
minimal
invasiveness,
controlled
release.
Among
these,
hydrogel
microneedles
(HMNs)
stand
out
their
extracellular
matrix-like
structure
swelling-induced
continuous
channels,
which
enable
the
direct
therapeutic
agents
into
tumor
microenvironment
(TME).
This
approach
enhances
bioavailability
while
reducing
toxicity,
establishing
HMNs
a
promising
platform
melanoma
treatment.
review
highlights
recent
advancements
in
therapy,
focusing
on
applications
biomarker
extraction
early
diagnosis
role
supporting
multimodal
treatment
strategies,
chemotherapy,
phototherapy,
targeted
combination
therapy.
Furthermore,
current
matrix
materials
fabrication
techniques
discussed.
Finally,
limitations
critically
analyzed,
recommendations
future
research
development
provided.
