Life,
Год журнала:
2024,
Номер
14(12), С. 1566 - 1566
Опубликована: Ноя. 29, 2024
Amino
acids
are
basic
building
blocks
of
structural
proteins
and
enzymes.
They
also
act
as
signaling
molecules
fuel.
characterized
essential
if
sufficient
quantities
must
be
supplied
exogenously
or
non-essential
they
can
endogenously
synthesized.
Appropriate
intake
amino
not
only
prevents
the
development
metabolic
diseases
but
reduce
progression
some
disease
states.
strongly
associated
with
retinal
metabolism
in
physiology
pathology.
Nonetheless,
there
is
a
lack
robust
clinical
studies
supporting
benefits
acid
supplementation
retinopathy.
In
this
review,
we
summarize
preclinical
evidence
concerning
potential
supplementing
taurine
histidine
to
provide
protection
against
diabetic
retinopathy,
glaucoma,
age-related
macular
degeneration.
We
suggest
further
directions
for
studying
acid-based
therapeutic
interventions
eye
diseases.
Medicine,
Год журнала:
2023,
Номер
102(40), С. e35285 - e35285
Опубликована: Окт. 6, 2023
Diabetes
mellitus
is
a
complex
chronic
metabolic
disease
characterized
by
hyperglycemia
and
various
complications.
According
to
the
different
pathophysiological
mechanisms,
these
complications
can
be
classified
as
microvascular
or
macrovascular
complications,
which
have
long-term
negative
effects
on
vital
organs
such
eyes,
kidneys,
heart,
brain,
lead
increased
patient
mortality.
major
global
health
issue,
its
incidence
prevalence
significantly
in
recent
years.
Moreover,
expected
continue
rise
more
people
adopt
Western
lifestyle
diet.
Thus,
it
essential
understand
epidemiology,
pathogenesis,
risk
factors,
treatment
of
vascular
aid
patients
managing
effectively.
This
paper
provides
comprehensive
review
literature
clarify
above
content.
Furthermore,
this
also
delves
into
correlation
between
novel
long
noncoding
RNAs,
gut
microbiota,
nonalcoholic
fatty
liver
disease,
with
diabetic
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 14, 2024
Abstract
Ulcerative
colitis
(UC)
is
increasingly
common,
and
it
gradually
become
a
kind
of
global
epidemic.
UC
type
inflammatory
bowel
disease
(IBD),
lifetime
recurrent
disease.
as
common
has
financial
burden
for
many
people
the
potential
to
develop
into
cancer
if
not
prevented
or
treated.
There
are
multiple
factors
such
genetic
factors,
host
immune
system
disorders,
environmental
cause
UC.
A
growing
body
research
have
suggested
that
intestinal
microbiota
an
factor
play
important
role
in
occurrence
development
Meanwhile,
evidence
date
suggests
manipulating
gut
microbiome
may
represent
effective
treatment
prevention
management
In
addition,
main
clinical
drugs
treat
amino
salicylate
corticosteroid.
These
always
some
side
effects
low
success
rate
when
treating
patients
with
Therefore,
there
urgent
need
safe
efficient
methods
Based
on
this,
probiotics
prebiotics
be
valuable
order
promote
wide
application
This
review
aims
summarize
recent
literature
aid
better
understanding
how
contributes
while
evaluating
prospecting
therapeutic
effect
based
previous
publications.
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1601 - 1601
Опубликована: Июль 18, 2024
Obesity,
along
with
metabolic
disorders
such
as
dyslipidemia
and
insulin
resistance,
increases
the
risk
of
cardiovascular
disease,
diabetes,
various
cancers,
other
non-communicable
diseases,
thereby
contributing
to
higher
mortality
rates.
The
intestinal
microbiome
plays
a
crucial
role
in
maintaining
homeostasis
influencing
human
metabolism.
This
study
enrolled
82
young
obese
individuals,
who
were
stratified
into
groups
or
without
disturbances.
No
significant
differences
alpha
beta
diversity
microbiota
observed
among
groups.
Insulin
resistance
was
characterized
by
an
increase
number
Adlercreutzia
Dialister
well
decrease
Collinsella,
Coprococcus
Clostridiales.
dyslipidemia+insulin
had
no
gut
microbiota.
Dietary
patterns
also
influenced
microbial
composition,
high
protein
intake
increasing
Leuconostoc
Akkermansia,
fiber
boosting
Lactobacillus
Streptococcus.
genus
Erwinia
associated
visceral
fat
serum
glucose
high-density
lipoprotein
cholesterol.
Our
findings
highlight
association
between
composition
disturbances
they
suggest
that
dietary
modifications
may
promote
healthy
reduce
developing
disorders.
Medicine,
Год журнала:
2024,
Номер
103(39), С. e39866 - e39866
Опубликована: Сен. 27, 2024
Recent
studies
reveal
that
alterations
in
gut
microbiota
play
a
significant
role
the
progression
of
various
diseases,
including
those
affecting
eyes.
The
association
between
and
eye
health
is
an
emerging
focus
research.
This
review
seeks
to
summarize
connection
microbiome
specific
conditions,
such
as
ocular
surface
funduscopic
disorders
immune-mediated
diseases.
Gut
may
influence
these
conditions
by
regulating
immune
system
or
altering
metabolites,
thereby
contributing
disease
development.
Strategies
like
probiotics,
antibiotics,
dietary
modifications,
fecal
transplants
show
promise
addressing
issues.
examines
how
be
linked
pathogenesis
providing
fresh
therapeutic
perspectives
for
ophthalmology.
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Optic
neuritis
(ON)
is
an
inflammatory
condition
often
linked
to
autoimmune
disorders
like
multiple
sclerosis
(MS)
and
neuromyelitis
optica
spectrum
disorder
(NMOSD).
Despite
its
low
incidence,
ON
can
lead
severe,
irreversible
visual
impairment.
Emerging
evidence
suggests
the
gut
microbiota
(GM)
may
influence
through
complex
immune
metabolic
pathways,
yet
mechanisms
remain
underexplored.
This
study
employed
a
multi-omics
Mendelian
randomization
(MR)
approach
assess
causal
relationships
between
GM
taxa
ON.
We
analyzed
data
from
extensive
genetic
profiling,
examining
effect
473
taxa,
731
cells/traits,
1400
metabolites,
vitamin
B6,
Our
methodology
involved
two-sample
MR
analysis
establish
causality
mediation
explore
potential
therapeutic
strategies.
identified
27
with
direct
relationship
risk.
Further
highlighted
three
particularly
strong
associations.
Mediation
revealed
specific
pathways
which
these
exert
their
effects,
including
notable
interactions
B6
metabolism,
appeared
mediate
some
of
relationships.
found
that
could
be
method
by
acting
on
in
advances
our
understanding
etiology
highlights
as
target
for
The
significant
role
new
avenues
prevention
treatment,
emphasizing
need
further
research
into
diet-based
interventions.
Poultry Science,
Год журнала:
2025,
Номер
unknown, С. 105156 - 105156
Опубликована: Апрель 1, 2025
A
total
of
180
one-day-old
white-feathered
broiler
chicks
were
selected
and
randomly
divided
into
4
treatments,
namely
the
control
group
(CON),
Escherichia
coli
groups
(E.
coli),
2
g/kg
polyherbal
mixture
(PHM2),
(PHM4).
The
CON
E.
fed
a
basal
diet,
while
PHM2
PHM4
diet
supplemented
with
PHM,
respectively.
Each
had
3
replicates,
15
broilers
per
replicate.
On
day
17
experiment,
in
coli,
PHM2,
intraperitoneally
injected
0.8
mL
1
×
108
CFU/mL
O78.
Broilers
received
an
equivalent
volume
saline.
Chicks
euthanized
48
h
postinjection
for
collecting
serum,
liver,
spleen,
jejunum,
ileum,
ileal
mucosa,
cecal
contents.
Our
results
showed
that
PHM
significantly
reversed
weight
loss
decreased
diarrhea
rate
mortality
caused
by
infection
(P
<
0.05).
In
serum
infected
enhanced
antioxidant
capacity
0.05),
increased
levels
immunoglobulins
anti-inflammatory
cytokines
concentrations
proinflammatory
Meanwhile,
also
promoted
mRNA
expression
antioxidant-related
genes
apoptosis-related
ileum
addition,
repaired
intestinal
barrier
injury
to
further
reduce
d-lactate
(DAO)
lipopolysaccharide
(LPS)
More
importantly,
regulated
composition
microbiota,
especially
up-regulating
relative
abundance
beneficial
bacteria,
including
Faecalibacterium,
Bacteroides,
Butyricicoccus,
Lactobacillus,
down-regulating
pathogenic
Enterococcus,
Escherichia,
Shigella
These
bacteria
positively
correlated
function,
conclusion,
may
be
potential
preventive
strategy
coli-infected
poultry,
which
is
closely
related
its
modulation
gut
microbiota.
BMC Endocrine Disorders,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 21, 2025
The
association
between
thyroid-stimulating
hormone
(TSH)
and
type
2
diabetes
mellitus
(T2DM)
is
well
known.
However,
whether
TSH
related
to
nonproliferative
diabetic
retinopathy
(NPDR)
has
not
been
studied.
This
study
aimed
explore
the
relationship
NPDR
in
Chinese
patients
with
T2DM.
In
this
cross-sectional
study,
427
T2DM
were
enrolled.
individuals
classified
into
two
groups
according
fundus
oculi
examination:
non-diabetic
(NDR)
group
(n
=
224)
non-proliferative
203).
individuals'
demographic
clinical
data
collected
by
reviewing
medical
records
direct
interviews.
biochemical
parameters
compared
using
Student's
t
-
test
or
Mann‒Whitney
U
test,
anthropometric
measurements,
thyroid
function,
evaluated,
associations
assessed
logistic
regression
models.
No
significant
differences
age,
sex,
body
mass
index
(BMI),
incidence
of
alcohol
consumption,
duration
found
these
groups.
systolic
blood
pressure
(SBP),
smoking,
TSH,
urea
nitrogen
(BUN),
urinary
micro-albumin
(mALB)
significantly
higher
than
NDR
(P
<
0.05).
Individuals
had
levels
thyroxine
(T4),
glutamic
pyruvic
transaminase
(ALT),
fasting
C-peptide
(FCP),
2-hour
(2hCP)
Spearman's
correlation
analysis
revealed
that
serum
negatively
associated
HbA1c
all
(r=-0.11,
P
Serum
correlated
(r
-0.19,
0.01)
positively
0.14,
0.05)
group.
Multivariate
high
levels,
duration,
high-density
lipoprotein
cholesterol
(HDL-C),
glycosylated
hemoglobin
(HbA1c),
FCP,
SBP
[odds
ratio
(OR)
>
1,
0.05].
Receiver
operating
characteristic
curve
optimal
cutoff
point
for
predicting
was
2.235
mIU/L.
level
independently
population
A
may
be
a
potential
risk
factor
an
indicator
screening
microangiopathy.
registered
Clinical
Trial
Registry
(02/21/2025
ChiCTR2500097614).
