HERALD of North-Western State Medical University named after I I Mechnikov,
Год журнала:
2024,
Номер
16(3), С. 44 - 59
Опубликована: Ноя. 6, 2024
BACKGROUND:
Solute
and
water
transport
by
peritoneal
membrane
has
significant
variation
between
patients;
the
function
changes
significantly
over
time.
This
affects
treatment
outcomes
requires
individual
approaches.
AIM:
To
evaluate
influence
of
baseline
state,
its
dynamics
during
dialysis
possibility
long-term
modification.
MATERIALS
AND
METHODS:
The
solutes
(in
equilibrium
test,
PET)
mini-PET)
was
evaluated
in
a
prospective
interventional
open-label
study
with
historical
control
among
96
unselected
consecutive
patients
admitted
three
centers
unified
program
monitoring
protection.
RESULTS:
Compared
to
matched
standard
arm,
increase
solute
slower
(by
9.5%)
observation
group.
Ultrafiltration
classical
PET
decreased
more
slowly
28%).
At
ultrafiltration
satisfactory
(the
proportion
less
400
ml
7.6%);
small
pores
did
not
decrease
(−1.1
±
5.9
ml/year),
total
32.1
8.2
ml/year)
due
free
29.9
7.6
ml/year).
Negative
associated
glucose
load
monthly
greater
than
2.68
kg/month.
More
one
case
peritonitis
rapid
decline
transport.
comorbidity
increased
34
patients,
median
first/last
scores
5
(4–6)
6
(4–7)
points;
(Wilcoxon
Z
=
−5.423;
p
0.001).
When
analyzed
separately
category,
worsening
index
observed
only
for
high
average
transporters
(Z
−2.754,
0.006
−3.357,
0.001,
respectively).
CONCLUSIONS:
interaction
transport,
primarily
cardiovascular
disease
is
certainly
two-way:
deterioration
balance
loss
effective
leads
volume
overload
progression
disease.
On
other
hand,
contributes
damage.
most
sensitive
interventions
effectiveness
protection
preventing
separate
measuring
through
ultrapores,
which
simultaneously
reveals
feature
progressive
fibrosis,
potential
precursor
encapsulating
sclerosis.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 813 - 813
Опубликована: Янв. 19, 2025
During
long-term
peritoneal
dialysis,
fibrosis
(PF)
often
happens
and
results
in
ultrafiltration
failure,
which
directly
leads
to
the
termination
of
dialysis.
The
accumulation
extracellular
matrix
produced
from
an
increasing
number
myofibroblasts
was
a
hallmark
characteristic
PF.
To
date,
glucose
degradation
products
(GDPs,
i.e.,
methylglyoxal
(MGO))
that
appeared
during
heating
storage
dialysate
are
considered
be
key
components
initiating
PF,
but
how
GDPs
lead
activation
myofibroblast
fibrotic
peritoneum
has
not
yet
been
fully
elucidated.
In
this
study,
mesothelial
cell
line
(MeT-5A)
fibroblast
(MRC-5)
were
used
investigate
transcriptomic
proteomic
changes
unveil
underlying
mechanism
MGO-induced
Our
data
MGO-stimulated
cells
showed
upregulation
genes
involved
pro-inflammatory,
apoptotic,
pathways.
While
no
phenotypic
noted
on
fibroblasts
after
direct
MGO,
supernatant
promoted
change
into
proto-myofibroblasts,
activated
first
stage
toward
myofibroblasts.
conclusion,
study
fibroblast-to-proto-myofibroblast
transition;
however,
additional
involvement
other
factors
or
(e.g.,
macrophages)
may
needed
complete
transformation
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 26, 2025
This
study
aimed
to
investigate
the
potential
relationship
between
baseline
glucose
lymphocyte
ratio
(GLR)
levels
and
first
episode
of
peritonitis
in
patients
treated
with
peritoneal
dialysis
(PD).
A
total
314
PD
were
included
divided
into
three
groups
based
on
GLR
tertiles:
tertile
1
(GLR
≤
4.23);
2
(4.23
<
5.96),
3
>
5.96).
The
relationships
analyzed
using
Kaplan–Meier
curves
multivariable
Cox
regression
models.
Competitive
risk
analysis,
subgroup
sensitivity
analyses
performed
validate
robustness
findings.
During
a
median
follow-up
27
months,
123
(39.17%)
developed
peritonitis.
incidence
increased
higher
tertiles
(tertile
1:
32.08%,
2:
37.50%,
3:
48.08%).
revealed
significant
differences
cumulative
among
(Log-Rank
test,
P
=
0.018).
After
full
adjustment
for
confounding
factors,
remained
at
significantly
compared
those
(HR
2.633,
95%
CI
1.223–5.668,
0.013).
models
analysis
further
confirmed
this
association.
Our
suggests
that
elevated
is
associated
an
PD.
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 27, 2025
Peritoneal
dialysis
(PD)
is
considered
a
life-saving
treatment
for
end-stage
renal
disease.
However,
prolonged
PD
use
can
lead
to
the
development
of
peritoneal
fibrosis
(PF),
diminishing
its
efficacy.
mesothelial
cells
(PMCs)
are
key
initiators
PF
when
they
become
damaged.
Exposure
high
glucose‑based
fluids
(PDFs)
contributes
by
directly
affecting
highly
metabolically
active
PMCs.
Recent
research
indicates
that
PMCs
undergo
metabolic
reprogramming
exposed
high-glucose
PDFs,
including
enhanced
glycolysis,
impaired
oxidative
phosphorylation,
abnormal
lipid
metabolism,
and
mitochondrial
dysfunction.
Although
this
transition
temporarily
compensates
cellular
damage
maintains
energy
levels,
long-term
impact
on
tissue
concerning.
Multiple
studies
have
identified
close
association
between
shift
in
metabolism
PF,
may
promote
progression
through
various
molecular
mechanisms.
This
review
explores
recent
findings
regarding
role
mechanism
PMC
progression.
Moreover,
it
provides
summary
potential
therapeutic
strategies
aimed
at
processes,
glucose
function.
The
establishes
targeting
be
novel
strategy
preventing
treating
PD-associated
fibrosis.
Overview
associated
with
implications.
Under
physiological
conditions,
primarily
produce
ATP
OXPHOS
FAO
maintain
functions.
High-glucose
PDFs
induce
PMCs,
characterized
increased
polyol
pathway,
PPP,
inhibited
OXPHOS,
FAO,
exocytosis
deposition,
These
changes
multiple
pathways.
Potential
target
absorption,
restoration,
fatty
acid
oxidation;
phosphorylation;
PD,
dialysis,
PDF,
fluid;
PMC,
cell;
pentose
phosphate
pathway.
Journal of Food Biochemistry,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Background:
This
study
aimed
to
evaluate
the
effect
of
Shenbing
Decoction
III
(SBD
III)
and
its
key
Apigenin
on
peritoneal
dialysis
(PD)–induced
fibrosis
explore
underlying
mechanisms.
Methods:
Liquid
chromatography–mass
spectrometry
confirmed
presence
in
SBD
III.
Human
mesothelial
cells
(HMrSV5)
were
stimulated
with
PD
solution
(PDS)
induce
fibrosis,
treatment
was
administered.
Results:
PDS
decreased
cell
viability
increased
migration
invasion
capabilities
HMrSV5
cells.
It
also
reduced
E‐cadherin
expression,
while
increasing
expression
α‐SMA,
fibronectin,
collagen
I,
TGF‐β1.
effectively
counteracted
these
effects.
Additionally,
inhibited
PDS‐induced
upregulation
phosphorylation
transforming
growth
factor‐β‐activated
kinase
1
(TAK1),
p38,
nuclear
factor‐κB
(NF‐κB),
similar
effects
5z‐7‐oxozeaenol.
Chronic
kidney
disease
(CKD)
induced
mice
by
5/6
nephrectomy,
followed
treatment.
The
therapeutic
evaluated.
CKD
exhibited
body
weight
indices,
along
elevated
blood
urea
nitrogen,
urinary
creatinine,
protein
levels.
Fibrosis
observed
kidneys
peritoneum.
significantly
alleviated
Notably,
further
augmented
when
Conclusion:
ameliorated
inhibiting
epithelial–mesenchymal
transition
via
TAK1/p38MAPK/NF‐κB
pathway,
indicating
promising
pharmaceutical
candidates
for
CKD.
Biosensors,
Год журнала:
2025,
Номер
15(3), С. 193 - 193
Опубликована: Март 18, 2025
Peritoneal
dialysis
(PD)
is
a
vital
treatment
for
end-stage
renal
disease
patients,
but
its
efficacy
often
compromised
by
complications
such
as
infections
and
peritoneal
fibrosis.
Biological
field-effect
transistors
(BioFETs)
present
promising
solution
rapid,
sensitive,
non-invasive
detection
of
indicators
biomarkers
associated
with
these
complications,
potentially
enabling
early
intervention.
However,
BioFETs
are
yet
to
be
adopted
PD
monitoring.
This
review
presents
forward-looking
analysis
the
capacity
potential
integration
into
management
systems,
highlighting
their
monitor
both
routine
efficiency
metabolic
status,
well
specific
inflammation
We
examine
challenges
in
adapting
applications,
focusing
on
key
areas
improvement,
including
sensitivity,
specificity,
stability,
reusability,
clinical
integration.
Furthermore,
we
discuss
various
approaches
address
challenges,
which
crucial
developing
point-of-care
(PoC)
multiplexed
wearable
devices.
These
advancements
could
facilitate
continuous,
precise,
user-friendly
monitoring,
revolutionizing
complication
enhancing
patient
care.
Therapeutic Apheresis and Dialysis,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
The
number
of
published
medical
articles
on
peritoneal
dialysis
(PD)
has
been
increasing,
and
efficiently
selecting
information
from
numerous
can
be
difficult.
In
this
study,
we
examined
whether
artificial
intelligence
(AI)
text
mining
a
good
support
for
collecting
PD
information.
We
performed
analyzed
all
the
abstracts
case
reports
in
PubMed
database.
total,
3137
with
related
to
"peritoneal
dialysis"
1970
2021
were
identified.
A
total
280
347
relevant
words
extracted
abstracts.
Word
frequency
analysis,
word
dependency
transition
analysis
showed
that
peritonitis,
encapsulating
sclerosis,
child
have
important
keywords.
Theseanalyses
not
only
reflected
historical
background
but
also
anticipated
future
trends
study.
These
suggest
Archives of Dermatological Research,
Год журнала:
2025,
Номер
317(1)
Опубликована: Апрель 1, 2025
Individuals
with
type
2
diabetes
mellitus
(T2DM)
not
only
face
the
risk
of
difficult
wound
healing
after
trauma
or
surgery
but
also
struggle
scar
formation
healing.
However,
relationship
between
T2DM
and
hypertrophic
scars
(HS)
remains
unclear.
First,
data
sets
related
to
HS
were
downloaded
from
OpenGWAS
database.
Second,
inverse
variance-weighted
(IVW)
technique
was
employed
assess
causal
impact
on
utilizing
mendelian
randomization
(MR).
Finally,
sensitivity
analyses
reverse
MR
performed
determine
robustness
findings
examine
potential
for
causation.
A
positive
observed.
Three
suitable
datasets
analysis
obtained
using
ids
ebi-a-GCST006867,
ebi-a-GCST007515,
ebi-a-GCST007516
(A
total
206,572
cases
753,191
controls
included).
The
(finn-b-L12_HYPETROPHICSCAR)
dataset
comprised
766
207,482
controls.
IVW
model
results
showed
odds
ratio
(OR)
1.213
(95%
confidence
interval
(CI):
1.04-1.41,
p
=
0.0137),
1.300
CI:
1.05-1.61,
0.017),
1.284
1.03-1.60,
0.0276),
respectively.
stable
without
any
significant
bias
causality.
This
study
systematically
explored
first
time,
provided
a
quantitative
effect
assessment.
consistency,
which
indicated
biological
mechanism
clinical
intervention
direction.
Clinical and Experimental Pharmacology and Physiology,
Год журнала:
2025,
Номер
52(7)
Опубликована: Май 25, 2025
ABSTRACT
AZ505,
a
highly
selective
inhibitor
of
SMYD2,
exhibits
an
antifibrotic
effect
in
renal
fibrosis.
Its
on
peritoneal
fibrosis
remains
unexplored.
In
this
study,
we
investigated
its
effects
the
development
induced
by
chlorhexidine
gluconate
(CG)
murine
model.
We
found
that
SMYD2
and
trimethylated
histone
substrate
H3K36
(H3K36me3)
were
expressed
tissue
following
CG
injection,
administration
AZ505
remarkably
inhibited
their
expression,
along
with
attenuating
CG–induced
expression
collagen
I
fibronectin.
Moreover,
also
significantly
reduced
CD31
(marker
angiogenesis)
CD68‐positive
macrophage
infiltration
CG‐injured
peritoneum.
further
CG‐induced
epithelial‐to‐mesenchymal
transition
(EMT)
mesothelial
cells,
manifested
decreasing
α‐smooth
muscle
antigen
(α‐SMA)
Vimentin
restoring
E‐cadherin
accompanied
suppressing
two
transcription
factors,
Snail
Twist.
Finally,
phosphorylation
AKT
increased
phosphatase
tensin
(PTEN),
key
phosphatase.
These
data
suggest
may
protect
against
inhibiting
EMT,
inflammation
angiogenesis,
due
to
blockade
methylation
modification
catalysed
SMYD2.
Peritoneal Dialysis International,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 28, 2024
Peritoneal
dialysis
adoption
and
technique
survival
is
affected
by
limitations
related
to
peritoneal
membrane
longevity
metabolic
alterations.
Indeed,
almost
all
fluids
exploit
glucose
as
an
osmotic
agent
that
rapidly
diffuses
across
the
membrane,
potentially
resulting
in
abnormalities
such
hyperglycemia,
hyperinsulinemia,
obesity,
hyperlipidemia.
Moreover,
glucose-degradation
products
generated
during
heat
sterilization,
other
than
itself,
induce
significant
morphological
functional
changes
peritoneum
leading
ultrafiltration
failure.
The
partial
substitution
of
with
agents
characterized
a
better
local
systemic
biocompatibility
has
been
suggested
potential
strategy
innovate
fluids.
approach
aims
minimize
glucose-associated
toxicity,
preserving
welfare
counteracting
common
comorbidities.
In
this
work,
we
report
clinical
trial
design
ELIXIR,
phase
III
randomized,
controlled,
blinded
outcome
assessment
study
comparing
Xylocore
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2377 - 2377
Опубликована: Окт. 17, 2024
Dyslipidemia
is
a
common
metabolic
complication
in
patients
undergoing
peritoneal
dialysis
(PD)
and
has
traditionally
been
viewed
primarily
terms
of
cardiovascular
risk.
Current
guidelines
do
not
recommend
initiating
lipid-lowering
therapy
due
to
insufficient
evidence
its
benefits
on
mortality.
However,
the
impact
dyslipidemia
PD
may
extend
beyond
concerns,
influencing
PD-related
outcomes
such
as
ultrafiltration
rate,
residual
kidney
function,
technique
survival,
overall
This
review
challenges
traditional
perspective
by
discussing
dyslipidemia’s
potential
role
complications,
which
account
for
observed
link
between
increased
all-cause
mortality
patients.
It
explores
pathophysiology
PD,
molecular
mechanisms
linking
membrane
dysfunction,
summarizes
clinical
supporting
this
hypothesis.
In
addition,
paper
examines
therapeutic
strategies
manage
improve
function
patient
outcomes.
The
calls
future
research
investigate
contributor
dysfunction
develop
targeted
interventions