Ginsenoside Rh2(S) maintains cytoskeleton homeostasis and inhibits pyroptosis to resist cisplatin-induced cardiotoxicity through FGFR1/HRAS axis
Phytomedicine,
Год журнала:
2025,
Номер
138, С. 156425 - 156425
Опубликована: Янв. 24, 2025
Язык: Английский
Modulation of NLRP3 inflammasome-related-inflammation via RIPK1/RIPK3-DRP1 or HIF-1α signaling by phenothiazine in hypothermic and normothermic neuroprotection after acute ischemic stroke
Redox Biology,
Год журнала:
2024,
Номер
73, С. 103169 - 103169
Опубликована: Апрель 26, 2024
Inflammation
and
subsequent
mitochondrial
dysfunction
cell
death
worsen
outcomes
after
revascularization
in
ischemic
stroke.
Receptor-interacting
protein
kinase
1
(RIPK1)
activated
dynamin-related
(DRP1)
a
NLRPyrin
domain
containing
3
(NLRP3)
inflammasome-dependent
fashion
Hypoxia-Inducible
Factor
(HIF)-1α
play
key
roles
the
process.
This
study
determined
how
phenothiazine
drugs
(chlorpromazine
promethazine
(C+P))
with
hypothermic
normothermic
modality
impacts
RIPK1/RIPK3-DRP1
HIF-1α
pathways
providing
neuroprotection.
A
total
of
150
adult
male
Sprague-Dawley
rats
were
subjected
to
2
h
middle
cerebral
artery
occlusion
(MCAO)
followed
by
24
reperfusion.
8mg/kg
C+P
was
administered
at
onset
Infarct
volumes,
mRNA
expressions
HIF-1α,
RIPK1,
RIPK3,
DRP-1,
NLRP3-inflammation
cytochrome
c-apoptosis
assessed.
Apoptotic
death,
infiltration
neutrophils
macrophages,
function
evaluated.
Interaction
between
RIPK1/RIPK3
HIF-1α/NLRP3
determined.
In
SH-SY5Y
cells
oxygen/glucose
deprivation
(OGD),
effect
on
inflammation
apoptosis
examined.
significantly
reduced
infarct
(ATP
ROS
concentration,
citrate
synthase
ATPase
activity),
without
induced
hypothermia.
Overexpression
NLRP3-inflammasome
all
33°C
RIPK1
inhibitor
(Nec1s),
suggesting
via
RIPK1/RIPK3-DRP1pathway.
When
body
temperature
maintained
37°C,
(YC-1)
expression,
leading
reduction
dysfunction,
NLRP3
inflammasome
c-apoptosis,
as
well
interaction
NLRP3.
These
also
evidenced
vitro,
indicating
HIF-1α.
Hypothermic
neuroprotection
involve
different
pathways.
The
mediated
while
signaling.
provides
theoretical
basis
for
future
precise
exploration
Язык: Английский
The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity
Wenxin Zhang,
Hongbo Teng,
Tianyi Zhao
и другие.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 15, 2025
Cisplatin
is
extensively
employed
in
the
treatment
of
multiple
solid
malignant
tumors.
Nevertheless,
side
effects
such
as
cisplatin-induced
ototoxicity
(CIO)
pose
obstacles
to
tumor
therapy.The
important
natural
product
chiisanoside
from
Acanthopanax
sessiliflorus
has
abundant
activity
against
CIO.
In
this
study,
26
derivatives
were
screened,
and
compound
19
demonstrated
significant
protective
CIO
damage.
A
HEI-OC1
cell
injury
model
a
mouse
established.
The
regulatory
revealed
through
transcriptome
sequencing,
protein
expression
levels
analyzed
by
molecular
docking,
ELISA,
Western
blotting,
immunofluorescence.
It
was
found
that
inhibited
apoptosis,
alleviated
abnormal
hearing
spiral
ganglion
Transcriptome
sequencing
its
effects.
Compound
increased
autophagy
levels,
thereby
alleviating
mitochondrial
dysfunction
reducing
accumulation
reactive
oxygen
species
(ROS).In-depth
studies
have
inhibitor
3-methyladenine
(3-MA)
weakens
effect
on
inhibits
clearance
damaged
cells,
resulting
oxidative
stress
damage,
apoptosis
necrosis.
By
knocking
down
LRP6,
it
eliminated,
level
significantly
reduced,
ROS
production
induced,
after
cisplatin
exposure
promoted.
Finally,
LiCl
used
suppress
GSK3β.
inhibiting
GSK3β
could
protect
cells
damage
activating
autophagy.
These
findings
suggest
capable
preventing
via
LRP6/GSK3β
axis
consequently
stress,
offering
new
approach
for
treating
sensorineural
loss.
Язык: Английский
Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway
Neurochemical Research,
Год журнала:
2025,
Номер
50(2)
Опубликована: Апрель 1, 2025
Язык: Английский
Design and synthesis of matrine derivatives for anti myocardial ischemia–reperfusion injury by promoting angiogenesis
Bioorganic & Medicinal Chemistry,
Год журнала:
2024,
Номер
108, С. 117776 - 117776
Опубликована: Май 30, 2024
Язык: Английский
Synthesis of furanotriterpenoids from betulin and evaluation of Tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibitory properties of new semi-synthetic triterpenoids
European Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
276, С. 116724 - 116724
Опубликована: Июль 27, 2024
Язык: Английский
Chiisanoside from the Leaves of Acanthopanax sessiliflorus Can Resist Cisplatin-Induced Ototoxicity by Maintaining Cytoskeletal Homeostasis and Inhibiting Ferroptosis
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(46), С. 25720 - 25742
Опубликована: Ноя. 6, 2024
Ototoxicity
is
a
common
side
effect
of
cisplatin
cancer
treatment,
potentially
leading
to
hearing
loss.
This
study
demonstrated
the
significant
protective
activity
Acanthopanax
sessiliflorus
(A.
sessiliflorus)
leaves
against
cisplatin-induced
ototoxicity
(CIO),
investigated
active
compounds,
and
elucidated
their
mechanisms
in
countering
CIO.
UPLC-Q/TOF-MS
analysis
identified
79
compounds.
Network
pharmacology
screening
determined
that
chiisanoside
(CSS)
plays
crucial
role
combating
Transcriptomics
combined
with
network
experiments
revealed
CSS
activates
Dock1/PIP5K1A
pathway
suppress
actin-severing
protein
gelsolin,
protecting
hair
cells
from
cytoskeleton
damage.
also
SLC7A11/GPX4
via
TGFBR2,
reducing
lipid
peroxidation
intracellular
iron
accumulation
ferroptosis.
discovers
major
component
A.
reverses
CIO
by
regulating
actin
homeostasis
Dock1
inhibiting
ferroptosis
through
providing
theoretical
basis
for
expanding
treatment
targets
related
drug
development.
Язык: Английский