Luteolin: A promising multifunctional natural flavonoid for human diseases

Phytotherapy Research, Год журнала: 2024, Номер 38(7), С. 3417 - 3443

Опубликована: Апрель 26, 2024

Abstract Natural products are closely associated with human health. Luteolin (LUT), a flavonoid polyphenolic compound, is widely found in fruits, vegetables, flowers, and herbs. It noteworthy that LUT exhibits variety of beneficial pharmacological properties holds significant potential for clinical applications, particularly antitumor, anti‐convulsion, diabetes control, anti‐inflammatory, neuroprotection, anti‐oxidation, anti‐cardiovascular, other aspects. The mechanism action has been partially elucidated, including the mediation NF‐κB, toll‐like receptor, MAPK, Wnt/β‐catenin, PI3K/Akt, AMPK/mTOR, Nrf‐2, among others. review aimed to comprehensively consolidate essential information on natural sources, effects, therapeutic preventive potential, as well mechanisms LUT. objective establish theoretical basis continued development application

Язык: Английский

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Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116909 - 116909

Опубликована: Июнь 8, 2024

Lung cancer is a prevalent malignant tumor and leading cause of cancer-related fatalities globally. However, current treatments all have limitations. Therefore, there an urgent need to identify readily available therapeutic agent counteract lung development progression. Luteolin flavonoid derived from vegetables herbs that possesses preventive effects on various cancers. With the goal providing new directions for treatment cancer, we review here recent findings luteolin so as provide ideas anti-lung drugs. The search focused studies published between January 1995 2024 explored use in cancer. A comprehensive literature was conducted SCOPUS, Google Scholar, PubMed, Web Science databases using keywords "luteolin" "lung cancer." By collecting previous literature, found has multiple mechanisms effects, including promotion apoptosis cells; inhibition cell proliferation, invasion metastasis; modulation immune responses. In addition, it can be used adjuvant radio-chemotherapy helps ameliorate complications. This summarizes structure, natural sources, physicochemical properties pharmacokinetics luteolin, focuses mechanism

Язык: Английский

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Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1354 - 1354

Опубликована: Окт. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Язык: Английский

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Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Neuroscience, Год журнала: 2025, Номер 569, С. 161 - 183

Опубликована: Фев. 7, 2025

Язык: Английский

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Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 12, 2025

Luteolin is a flavonoid widely found in plants, including vegetables, botanical drugs, and fruits. Owing to its diverse pharmacological activities, such as anticancer, oxidative stress protection, anti-inflammatory, neuron-preserving effects, luteolin has attracted attention research medicine. exhibits therapeutic effects on various pulmonary disease models through multiple molecular mechanisms; these include inhibition of activation the PI3K/Akt-mediated Nuclear Factor kappa-B (NF-κB) MAPK signaling pathways, well promotion regulatory T cell (Treg) function enhancement alveolar epithelial sodium channel (ENaC) activity (alleviating inflammation responses). chronic obstructive (COPD), acute lung injury/acute respiratory distress syndrome (ALI/ARDS), fibrosis, allergic asthma, cancer. Luteolin, naturally occurring polyphenol, poorly water-soluble. The oral route may be ineffective because gut absorbs this type flavonoid. Therefore, although significant biological activity, clinical application limited by challenges associated with poor water solubility low bioavailability, which are critical factors for efficacy application. These can addressed modifying chemical structure enhancing pharmaceutical formulations. We summarized advancements improving bioavailability luteolin, diseases their related mechanisms, aim providing new ideas researchers.

Язык: Английский

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Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Poultry Science, Год журнала: 2024, Номер 103(7), С. 103817 - 103817

Опубликована: Май 1, 2024

Cadmium (Cd) is a common environmental pollutant associated with an increased incidence of renal metabolic diseases. Luteolin (Lut), natural flavonoid, widely used for its multifaceted therapeutic properties in inflammatory However, whether Lut protects against Cd-induced nephrotoxicity still equivocal. The present study investigated the effects supplementation on oxidative stress, inflammation and metabolism their related mechanisms. Therefore, 40 chickens were treated Cd and/or automatic water free food intake 1 mo then kidney tissues collected to explore this issue. In study, exposure induced glycolipid disorders resultant damage by periodic acid Schiff (PAS) staining, Oil Red O total cholesterol (TC), triglyceride (TG), glucose (Glu) levels kidney, which significantly ameliorated Lut. Moreover, also normalized expression factors Cd-disturbed metabolism, improving homeostasis, contributing alleviating damage. Furthermore, demonstrated potential stress enhancing antioxidant capacity inhibiting cytokine production tissues. Mechanistically, activated AMPK/SIRT1/FOXO1 signaling pathway, attenuating responses, ameliorating disturbance. conclusion, these observations demonstrate that treatment activates decreases response, may contribute prevent disorder consequent

Язык: Английский

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Phytochemicals as Potential Lead Molecules against Hepatocellular Carcinoma

Current Medicinal Chemistry, Год журнала: 2024, Номер 31(32), С. 5199 - 5221

Опубликована: Янв. 12, 2024

Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, accounting for 85-90% cancer cases and a leading cause cancer-related mortality worldwide. The major risk factors HCC include hepatitis C B viral infections, along with chronic diseases, such as cirrhosis, fibrosis, non-alcoholic steatohepatitis associated metabolic syndrome. Despite advancements in modern medicine, there continuous rise annual global incidence rate HCC, it estimated to reach >1 million by 2025. Emerging research phytomedicine chemotherapy has established anti-cancer potential phytochemicals, owing their diverse biological activities. In this review, we report phytochemicals that have been explored combating hepatocellular possess great be used an alternative or conjunction existing treatment modalities. An overview pre-clinical observations, mechanism action molecular targets some these also incorporated.

Язык: Английский

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Harnessing Luteolin's therapeutic potential in human disorders: Medicinal significance, biological, clinical properties and analytical aspects

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер 10, С. 100401 - 100401

Опубликована: Фев. 22, 2024

Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a common flavonoid in many fruits, vegetables, and medicinal herbs. Plants rich luteolin have been used Chinese traditional medicine for treating various diseases, such as hypertension, inflammatory disorders, cancer. Throughout history, herbal medicines employed to address range of health issues their associated complications. This review delves into the biological characteristics, pharmacological importance, clinical analytical aspects potential use. study explores properties relevance luteolin, drawing support from both applications scientific findings. The information on has curated reputable sources Science Direct, PubMed, Google Scholar, Google, Scopus. Additionally, this paper incorporates data books, journals, reports provide well-rounded understanding luteolin's properties. Scientific investigations underscored significance diverse luteolin. Research revealed efficacy exhibiting anti-inflammatory, antioxidant, anti-cancer, wound healing, antimicrobial, antiviral, COVID-19 related Furthermore, its effectiveness extends anti-aging, antiallergic, cardioprotective, arthritis, neuroprotective, periodontal disorder, renal hepatoprotective, eye obesity, cytotoxicity, genotoxicity. compounds versatility therapeutic agent accentuated by adept interaction with molecular targets, influencing crucial cellular pathways. article provides pertaining identification isolation samples, underscoring across spectrum health-related domains. present highlights importance showcasing applicability addressing human diseases mitigating side effects. ADAM, A disintegrin Metalloproteinase; AMPK, Adenosine monophosphate, Activated protein kinase; AOM, azoxymethane; AP, activator protein; ApoE, apolipoprotein E-deficient; AR, Androgen receptor; ASD, Autistic disorders; CCl4, Tetrachloromethane; ccRCC, Clear cell carcinoma; CIA, Collagen-induced arthritis; CK-MB, Creatine kinase-MB; COVID-19,Coronavirus disease 2019; COX-2, Cyclooxygenase-2; DEDD2, Death effector domain-containing 2; EGFR, Epidermal growth factor FZD6, Frizzled class receptor6; FZJDXJ, Fuzheng Jiedu Xiaoji formulation; GBM, Glioblastoma multiforme grade IV; H. pylori, Helicobacter pylori; HBV, Hepatitis B virus; HCC, Hepatocellular HGI, Hypertrophic factor; HIV, Human immunodeficiency HNF4α, Hepatocyte nuclear 4α; IgE, Immunoglobulin E; IL, Interleukin; iNOS, Inducible nitric oxide synthase; IRAK1, Inhibiting interleukin-1 receptor-associated JNK, Jun N terminal K. Ras, Kirsten rat sarcoma L7Gn, Luteolin-7-O-glucuronide; LDH, Lactate dehydrogenase; LIP, Labile iron pool; LPS, Lipopolysaccharide; LTL, Luteolin; MAPK, Mitogen-activated MDA, Malondialdehyde; MICs, Minimum inhibitory concentrations; MMP-1, Matrix metalloproteinase 1; MPTP, Mitochondrial permeability transition pores; MRSA, Methicillin-resistant staphylococcus aureus; MSH, Melanocyte-stimulating hormone; MTP, transmembrane potential; NAFLD, Non-alcoholic fatty liver disease; NF, NF-κB, Nuclear factor-kappa B; Nlrp3, NOD-like receptor family pyrin domain containing 3; NO, Nitric oxide; NRCMs, Neonatal cardiomyocytes; Nrf2, erythroid NSCLC, Non-small lung cancer; PARP, poly-ADP ribose polymerase; PC, Prostate PDEF, Prostate-derived Ets PEA, Palmitoylethanolamide; PFS, Progression-free survival; POD, Post-operative delirium; PSA, Prostate-specific antigen levels; qPCR, Quantitative Polymerase chain reaction; ROS, Reactive oxygen species; Rpt, Proteasome-regulated particles; RTPCR, Real-time reverse transcriptase-polymerase SARS-CoV-2, Severe acute respiratory syndrome coronavirus SOD, Superoxide dismutase; SREBP, Sterol regulatory element binding sT antigen, Soluble tumor antigen; STAT, Signal transducer transcription; Syk, Spleen Tyrosine Kinase; TACE, Transcatheter arterial chemoembolization; TCM, Traditional chinese medicines; TNF-α, Tumor necrosis factor-α; TRAIL, TNF apoptosis-inducing ligand; TXNIP, Thioredoxin interacting protein.

Язык: Английский

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In situ fabrication of Ag nanoparticles modified vertically-grown ZnO nanorods on carbon fiber paper electrode for simultaneous detection of luteolin, daidzein and baicalein

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 694, С. 134118 - 134118

Опубликована: Апрель 30, 2024

Язык: Английский

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Detoxification of Aflatoxin B₁ by Phytochemicals in Agriculture and Food Science

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(26), С. 14481 - 14497

Опубликована: Июнь 19, 2024

Aflatoxin B

Язык: Английский

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