Anxiogenic-like effects of coumarin, possibly through the GABAkine interaction pathway: Animal studies with in silico approaches DOI
Abdullah Al Shamsh Prottay,

Emamuzzaman,

Tawfik Rakaiyat Ripu

и другие.

Behavioural Brain Research, Год журнала: 2024, Номер 480, С. 115392 - 115392

Опубликована: Дек. 10, 2024

Язык: Английский

Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies DOI Creative Commons

Mst. Farjanamul Haque,

Heba A. S. El‐Nashar, Md. Showkoth Akbor

и другие.

Frontiers in Chemistry, Год журнала: 2024, Номер 12

Опубликована: Апрель 16, 2024

Introduction: D-pinitol, a naturally occurring inositol, has diverse biological activities like antioxidant, antimicrobial and anticancer activities. This study aimed to evaluate anti-inflammatory effect of d-pinitol in chick model. Additionally, silico studies were performed the molecular interactions with cyclooxygenase-2 (COX-2). Methods: The tested groups received (12.5, 25, 50 mg/kg) standard drugs celecoxib ketoprofen (42 via oral gavage prior formalin injection. Then, number licks was counted for first 10 min, paw edema diameter measured at 60, 90, 120 min. Results Discussion: significantly ( p < 0.05) reduced diameters, compared negative control. When combined celecoxib, it inflammatory parameters more effectively than individual groups. showed promising binding capacity COX-2. Taken together, exerted effects dose-dependent manner, possibly through COX-2 interaction pathway.

Язык: Английский

Процитировано

8
Sclareol exerts an anti-inflammatory effect, possibly through COXs inhibition pathway: In vivo and in silico studies DOI Creative Commons
Abdullah Al Shamsh Prottay, Mehedi Hasan Bappi, Md. Showkoth Akbor

и другие.

Pharmaceutical Science Advances, Год журнала: 2023, Номер 2, С. 100029 - 100029

Опубликована: Ноя. 23, 2023

Chronic and severe inflammation results in many diseases disorders humans. Currently, available conventional anti-inflammatory drugs have numerous mild-to-severe side effects. Thus, there is a need for safe, effective, affordable, alternative drugs. This study aimed to evaluate the effect of sclareol (SCL), diterpene alcohol that principal ingredient refined oil Salvia sclarea (L.), through vivo silico studies. For this, we examined individual combined effects SCL (5, 10, 20 mg/kg) standard celecoxib (CXB) or ketoprofen (KPN) at 42 mg/kg (p.o.) on formalin-induced inflammatory Swiss mice. Additionally, an analysis was conducted potential mechanism this study. potentiality standards interact with cyclooxygenase (COX-1 COX-2) receptors. Our findings suggest exhibits dose-dependent SCL-20 significantly reduced number paw licks edema diameters. Moreover, CXN-42 KPN-42 demonstrated better In comparison standards, revealed comparable binding interaction COX-1 COX-2 receptors molecular docking Furthermore, displayed remarkable pharmacokinetic characteristics. conclusion, dose-dependently diameters animals. may be responsible producing by interacting

Язык: Английский

Процитировано

19
Anxiolytic-like effect of daidzin possibly through GABAA receptor α2 and α3 subunits interaction pathway: in vivo and in silico studies DOI
Muhammad Torequl Islam, Abdullah Al Shamsh Prottay, Md. Showkoth Akbor

и другие.

Pharmacological Research - Natural Products, Год журнала: 2024, Номер unknown, С. 100090 - 100090

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

4
Anti-arthritic potential of linalool: in vitro, in vivo, and in silico mechanistic insights for safer therapeutic applications DOI

S U Ahammed,

Raihan Chowdhury, Md. Sakib Al Hasan

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

0
Daidzin Enhances the Anticonvulsion Effects of Carbamazepine and Diazepam, Possibly Through Voltage-Gated Sodium Channels and GABAA-Dependent Pathways DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Jannatul Ferdous

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Язык: Английский

Процитировано

0
GABAergic antidepressant effect of daidzin: in vivo approach with in silico receptor binding affinities DOI
Muhammad Torequl Islam, Md. Showkoth Akbor, Md. Shimul Bhuia

и другие.

In Silico Pharmacology, Год журнала: 2025, Номер 13(1)

Опубликована: Апрель 15, 2025

Язык: Английский

Процитировано

0
Tangeretin exerts and modulates the anxiolytic effects of the GABAkine drugs diazepam and flumazenil in mice: molecular interventions through animal behaviour and molecular dynamic simulations DOI
Zakir Husain,

Md. Saifiuzzaman,

Md. Shimul Bhuia

и другие.

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105469 - 105469

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

1
Anxiogenic-like effects of coumarin, possibly through the GABAkine interaction pathway: Animal studies with in silico approaches DOI
Abdullah Al Shamsh Prottay,

Emamuzzaman,

Tawfik Rakaiyat Ripu

и другие.

Behavioural Brain Research, Год журнала: 2024, Номер 480, С. 115392 - 115392

Опубликована: Дек. 10, 2024

Язык: Английский

Процитировано

0