Physiological Research,
Год журнала:
2024,
Номер
Suppl. 3, С. S671 - S684
Опубликована: Дек. 31, 2024
Disproportion
between
reactive
oxygen
species
(ROS)
production
and
the
body's
antioxidant
system
can
cause
oxidative
stress,
which
is
considered
a
common
denominator
in
various
pathological
conditions,
including
cardiovascular
diseases,
aging,
cognitive
disorders.
The
generation
of
free
radicals,
occurs
through
partial
reduction
oxygen,
quickly
overwhelm
endogenous
capacity
cell.
This
causes
lipid,
protein,
DNA
RNA
damage,
inflammation,
overall
cell
degeneration,
be
mitigated
by
antioxidants.
However,
their
use
human
medicine
did
not
bring
expected
effect.
Molecular
hydrogen
(H2),
due
to
its
unique
physical
chemical
properties,
provides
number
benefits
for
alleviating
stress.
H2
superior
conventional
antioxidants
as
it
selectively
reduce
(.)OH
radicals
while
preserving
important
ROS
that
are
otherwise
used
normal
signaling.
Key
words
Oxidative
Cardiovascular
hydrogen,
ROS,
Inflammation.
Abstract
Hydrogen
as
a
therapeutic
agent
has
attracted
great
deal
of
attention
because
its
superior
outcome
on
many
diseases,
including
inflammatory
injury,
tumors,
metabolic
disorders,
and
neurological
diseases.
Photocatalytic
hydrogen
evolution
emerged
promising
strategy
for
production
delivery.
This
review
article
presents
the
recent
developments
in
design
synthesis
conjugated
polymer
materials,
linear
polymers
crosslinked
photocatalytic
evolution.
Particularly,
we
focus
this
development
photocatalysts
resulting
therapy
fields
anti‐inflammatory,
free
radical
scavenging,
cancer
treatment.
Finally,
discusses
future
research
perspective
materials
potential
clinical
applications
agent.
Depression and Anxiety,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
The
escalating
global
prevalence
of
type
2
diabetes
mellitus
(T2DM)
and
mental
disorder
(MD)
including
schizophrenia,
bipolar
disorder,
major
depressive
anxiety
highlights
the
urgency
for
comprehensive
therapeutic
strategies.
Aerobic
exercise
(AE)
is
a
viable
adjunct
therapy,
providing
significant
benefits
individuals
dealing
with
both
T2DM
MD.
This
review
consolidates
evidence
on
AE's
role
in
alleviating
physiological
psychological
effects
these
comorbid
conditions.
It
delves
into
pathophysiological
connections
between
various
MD,
depression,
anxiety,
disorder-emphasizing
their
reciprocal
exacerbation.
Key
neurophysiological
mechanisms
through
which
AE
confers
are
explored,
neuroinflammation
modulation,
brain
structure
neuroplasticity
enhancement,
growth
factor
expression
regulation,
hypothalamic-pituitary-adrenal
(HPA)/microbiota-gut-brain
(MGB)
axis
normalization.
Clinical
results
indicate
that
significantly
improves
metabolic
parameters
patients
substantial
argument
integrating
treatment
plans.
Future
research
should
aim
to
establish
detailed,
personalized
prescriptions
explore
long-term
this
population.
underscores
potential
complement
existing
modalities
enhance
management
Physiological Research,
Год журнала:
2024,
Номер
Suppl. 3, С. S671 - S684
Опубликована: Дек. 31, 2024
Disproportion
between
reactive
oxygen
species
(ROS)
production
and
the
body's
antioxidant
system
can
cause
oxidative
stress,
which
is
considered
a
common
denominator
in
various
pathological
conditions,
including
cardiovascular
diseases,
aging,
cognitive
disorders.
The
generation
of
free
radicals,
occurs
through
partial
reduction
oxygen,
quickly
overwhelm
endogenous
capacity
cell.
This
causes
lipid,
protein,
DNA
RNA
damage,
inflammation,
overall
cell
degeneration,
be
mitigated
by
antioxidants.
However,
their
use
human
medicine
did
not
bring
expected
effect.
Molecular
hydrogen
(H2),
due
to
its
unique
physical
chemical
properties,
provides
number
benefits
for
alleviating
stress.
H2
superior
conventional
antioxidants
as
it
selectively
reduce
(.)OH
radicals
while
preserving
important
ROS
that
are
otherwise
used
normal
signaling.
Key
words
Oxidative
Cardiovascular
hydrogen,
ROS,
Inflammation.
