Natural Compounds for Preventing Age-Related Diseases and Cancers

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7530 - 7530

Опубликована: Июль 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Язык: Английский

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JAG1/Notch Pathway Inhibition Induces Ferroptosis and Promotes Cataractogenesis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 307 - 307

Опубликована: Янв. 1, 2025

Cataracts remain the leading cause of visual impairment worldwide, yet underlying molecular mechanisms, particularly in age-related cataracts (ARCs), are not fully understood. The Notch signaling pathway, known for its critical role various degenerative diseases, may also contribute to ARC pathogenesis, although specific involvement is unclear. This study investigates regulating ferroptosis lens epithelial cells (LECs) and impact on progression. RNA sequencing anterior capsule samples from patients revealed a significant downregulation signaling, coupled with an upregulation ferroptosis-related genes. Notch1 expression decreased, while markers increased age-dependent manner. In vitro, alleviated by decreasing ferritin heavy chain 1 (FTH1) p53 levels enhancing nuclear factor erythroid 2-related 2 (Nrf2), glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11). Conversely, inhibition exacerbated ferroptosis, as evidenced reduced Nrf2, GPX4, SLC7A11 expression. These findings suggest that promotes LECs impairing Nrf2/GPX4 antioxidant thereby contributing development. offers new insights into pathogenesis highlights pathway potential therapeutic target preventing or mitigating

Язык: Английский

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Notch signaling pathway in osteogenesis, bone development, metabolism, and diseases

The FASEB Journal, Год журнала: 2025, Номер 39(4)

Опубликована: Фев. 22, 2025

Abstract The skeletal system provides vital importance to support organ development and functions. Notch signaling pathway possesses well‐established functions in cellular homeostasis. comprises five typical ligands ( JAG1 , JAG2, DLL1, DLL3, DLL4), four receptors 1‐4), intracellular domains (NICD1‐4). Each component of the has been demonstrated be fundamental osteoblast differentiation bone formation. dysregulation is highly linked with disorders or diseases at developmental postnatal stages. Recent studies have highlighted elements system, as well its interaction signaling, such Wnt/β‐catenin, BMP, TGF‐β, FGF, autophagy, hedgehog (Hh) construct a potential gene regulatory network orchestrate osteogenesis ossification. Our review provided comprehensive summary insights targeting for innovative drug discovery targets therapeutic interventions treat disorders, osteoporosis osteoarthritis. An in‐depth molecular mechanistic strategy modulate associated will encouraged consideration trigger enhanced approaches by defining Notch‐regulating drugs clinical use.

Язык: Английский

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Strategy for drug repurposing in fibroadipogenic replacement during muscle wasting: application to duchenne muscular dystrophy

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Март 26, 2025

Background Understanding the cell functionality during disease progression or drugs’ mechanism are major challenges for precision medicine. Predictive models describing biological phenotypes can be challenging to obtain, particularly in scenarios where sample availability is limited, such as case of rare diseases. Here we propose a new method that reproduces fibroadipogenic expansion occurs muscle wasting. Methods We used immortalized progenitor cells (FAPs) and differentiated them into fibroblasts adipocytes. The successfully identified FAPs differentiation fate using accurate measurements changes specific proteins, which ultimately constitute valid cellular vitro platform drug screening. Results were confirmed primary well comparison with omics data from proteomics genomic studies. Our allowed us screen 508 different drugs 2 compounds libraries. Out these 508, 4 reduced fibrogenesis adipogenesis ≥30% cells. After selecting optimal dose each compound, inhibitory effect on FAP was by healthy subjects (n = 3) DMD patients 3). final selected hits fibrogenic samples. inhibition more evident samples than creating an map tested drugs, validated signalling pathways involved analysing proteomic Conclusion present molecular targets approved helps predicting therapeutic option may affect differentiation. This allows study potential circuits after treatment providing insights action degeneration. accuracy demonstrated comparing signal pathway activity obtained patient-derived

Язык: Английский

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Osteosarcopenia, osteoarthritis and frailty: a two-sample Mendelian randomization study

Aging Clinical and Experimental Research, Год журнала: 2025, Номер 37(1)

Опубликована: Апрель 21, 2025

Abstract Background Musculoskeletal disease, which has a complicated relationship with frailty, is common clinical problem among elderly individuals. Aims This study evaluated the potential causal relationships between osteosarcopenia, osteoarthritis and frailty by Mendelian Randomization (MR) analysis. Methods employed two-sample MR approach to investigate frailty. Published summary statistics were used obtain instrumental variables at genome-wide significance level. Results Among age groups osteoporosis, high total bone mineral density (TBMD) (45—60, OR = 0.966, 95% CI 0.940–0.993, P 0.013) TBMD (over 60, 0.974, 0.954–0.994, 0.011) reduced risk of Similarly, forearm BMD (FA-BMD), ultradistal (UFA-BMD), Heel-BMD different sites also (OR 0.936–0.996, 0.028; 0.975, 0.953–0.997, 0.029; 0.981, 0.967–0.995, 0.008). characteristics related sarcopenia, grip strength in left hand, right appendicular lean mass, walking pace all protective factors for 0.788, 0.721–0.862, < 0.001; 0.800, 0.737–0.869, 0.955, 0.937–0.974, 0.000; 0.480, 0.388–0.593, 0.001), low those over 60 years significantly positively correlated 1.168, 1.059–1.289, 0.002). The results revealed specific joint including KOA 1.086, 1.017–1.160, 0.014), HOA 1.028, 1.007–1.049, 0.009), KOA/HOA 1.082, 1.053–1.113, 0.000), increasing Conclusion Osteosarcopenia, exhibit significant effects, rendering them Therefore, practice, patients osteosarcopenia should be required undergo relevant interventions reduce

Язык: Английский

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Cancer Stem Cells: Robust Features and Therapeutic Targets

Interdisciplinary cancer research, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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