Journal of Orthopaedic Surgery and Research,
Год журнала:
2024,
Номер
19(1)
Опубликована: Дек. 5, 2024
Low
back
pain
caused
by
intervertebral
disc
degeneration
(IDD)
has
emerged
as
a
significant
global
public
health
concern,
with
far-reaching
consequences
for
patients'
quality
of
life
and
healthcare
systems.
Although
previous
research
have
revealed
that
the
mechanisms
cell
apoptosis,
pyroptosis
necroptosis
can
aggravate
IDD
damage
mediating
inflammation
promoting
extracellular
matrix
degradation,
but
they
cannot
explain
connection
between
different
death
ion
metabolism
disorders.
The
latest
study
shows
such
cellular
senescence,
ferroptosis,
cuproptosis,
PANopotosis
similar
roles
in
progression
degeneration,
not
exactly
same
mechanism.
This
paper
summarizes
effects
various
patterns
on
disease
IDD,
related
molecular
signaling
pathways,
providing
new
perspectives
potential
clinical
intervention
strategies
prevention
treatment
IDD.
Advanced Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Abstract
Ferroptosis,
as
novel
type
of
regulated
cell
death
that
has
garnered
widespread
attention
over
the
past
decade,
witnessed
continuous
discovery
an
increasing
number
regulatory
mechanisms.
Trace
metal
elements
play
a
multifaceted
and
crucial
role
in
oncology.
Interestingly,
it
been
increasingly
evident
these
elements,
such
copper,
are
involved
regulation
iron
accumulation,
lipid
peroxidation
antiferroptotic
systems,
suggesting
existence
“nonferrous”
mechanisms
ferroptosis.
In
this
review,
comprehensive
overview
composition
mechanism
ferroptosis
is
provided.
The
interaction
between
copper
metabolism
(including
cuproptosis)
cancer,
well
roles
other
trace
(such
zinc,
manganese,
cobalt,
molybdenum)
specifically
focused.
Furthermore,
applications
nanomaterials
based
on
metals
cancer
therapy
also
reviewed
potential
strategies
for
co‐targeting
cuproptosis
explored.
Nevertheless,
light
intricate
ambiguous
nature
interactions,
ongoing
research
essential
to
further
elucidate
ferroptosis,
thereby
facilitating
development
therapeutic
targets
approaches
treatment.
Abstract
Background
Muscle-invasive
bladder
cancer
(MIBC)
is
a
prevalent
and
aggressive
malignancy.
Ferroptosis
cuproptosis
are
recently
discovered
forms
of
programmed
cell
death
(PCD)
that
have
attracted
much
attention.
However,
their
interactions
impacts
on
MIBC
overall
survival
(OS)
treatment
outcomes
remain
unclear.
Methods
Data
from
the
TCGA-BLCA
project
(as
training
set),
cBioPortal
database,
GEO
datasets
(GSE13507
GSE32894,
as
test
sets)
were
utilized
to
identify
hub
ferroptosis/cuproptosis-related
genes
(FRGs
CRGs)
develop
prognostic
signature.
Differential
expression
analysis
(DEA)
was
conducted,
followed
by
univariate
multivariate
Cox’s
regression
analyses
multiple
machine
learning
(ML)
techniques
select
genetic
features.
The
performance
signature
evaluated
using
Kaplan–Meier
(K–M)
receiver-operating
characteristics
(ROC)
curves.
Mutational
tumour
immune
microenvironment
landscapes
also
explored.
Real-time
quantitative
reverse
transcription
polymerase
chain
reaction
(RT-qPCR)
experiments
confirmed
patterns
genes,
functional
assays
assessed
effects
SCD
knockdown
viability,
proliferation,
migration.
Results
DEA
revealed
dysregulated
FRGs
CRGs
in
TCGA
cohort.
SCD,
DDR2,
MT1A
identified
genes.
A
based
sum
weighted
these
demonstrated
strong
predictive
efficacy
sets.
Nomogram
incorporating
this
accurately
predicted
1-,
3-,
5-year
probabilities
cohort
GSE13507
dataset.
Copy
number
variation
(CNV)
high
risk
score
level
groups
associated
with
immunosuppression
lower
purity.
associations
scores
immunotherapy
chemical
drugs
explored,
indicating
potential
for
guiding
patients.
three
validated
RT-qPCR
experiments.
Conclusions
Targeting
could
be
promising
therapeutic
approach
MIBC.
Our
model
offers
new
framework
subtyping
can
inform
personalized
strategies.
Journal of Orthopaedic Surgery and Research,
Год журнала:
2024,
Номер
19(1)
Опубликована: Дек. 5, 2024
Low
back
pain
caused
by
intervertebral
disc
degeneration
(IDD)
has
emerged
as
a
significant
global
public
health
concern,
with
far-reaching
consequences
for
patients'
quality
of
life
and
healthcare
systems.
Although
previous
research
have
revealed
that
the
mechanisms
cell
apoptosis,
pyroptosis
necroptosis
can
aggravate
IDD
damage
mediating
inflammation
promoting
extracellular
matrix
degradation,
but
they
cannot
explain
connection
between
different
death
ion
metabolism
disorders.
The
latest
study
shows
such
cellular
senescence,
ferroptosis,
cuproptosis,
PANopotosis
similar
roles
in
progression
degeneration,
not
exactly
same
mechanism.
This
paper
summarizes
effects
various
patterns
on
disease
IDD,
related
molecular
signaling
pathways,
providing
new
perspectives
potential
clinical
intervention
strategies
prevention
treatment
IDD.
