Association between the use of statins and in-hospital mortality risk in patients with sepsis-induced coagulopathy during ICU stays: a study based on medical information mart for intensive care database

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Июль 25, 2024

Abstract Background The objective of this study was to explore the correlation between statin administration in intensive care unit (ICU) setting and in-hospital mortality risk patients suffering from sepsis-induced coagulopathy (SIC). Methods Utilizing a retrospective cohort design, investigation collected data Medical Information Mart for Intensive Care (MIMIC)-IV spanning 2008 2019. diagnosis SIC established based on score 4 or above. Statin usage during ICU period extracted prescription records keywords medications. primary endpoint analyzed within ICU, characterized by any death occurring admission. Results During follow-up, which had median duration approximately 7.28 days, 18.19% 4,777 died ICU. linked with decrease [hazard ratio (HR): 0.73, 95% confidence interval (CI): 0.60–0.89, P = 0.002]. Relative rosuvastatin, use atorvastatin (HR: 0.54, CI: 0.34–0.85, 0.008) simvastatin 0.55, 0.33–0.92, 0.024), as well combinations multiple statins 0.36, 0.15–0.86, 0.022), associated reduction risk. Subgroup analysis also suggested that atorvastatin, simvastatin, combination an advantage over rosuvastatin reducing older than 65 years age respiratory failure cardiogenic shock (all < 0.05). Conclusion present supports potential benefits stays. encourages clinicians consider ongoing exploration enhanced outcomes critical settings.

Язык: Английский

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Impact of statin therapy on CD40:CD40L signaling: mechanistic insights and therapeutic opportunities

Pharmacological Reports, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Язык: Английский

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Therapeutic Modulation of Arginase with nor-NOHA Alters Immune Responses in Experimental Mouse Models of Pulmonary Tuberculosis including in the Setting of Human Immunodeficiency Virus (HIV) Co-Infection

Tropical Medicine and Infectious Disease, Год журнала: 2024, Номер 9(6), С. 129 - 129

Опубликована: Июнь 6, 2024

L-arginine metabolism is strongly linked with immunity to mycobacteria, primarily through the antimicrobial activity of nitric oxide (NO). The potential modulate tuberculosis (TB) outcomes interventions that target pathways are limited by an incomplete understanding mechanisms and inadequate in vivo modeling. These gaps knowledge compounded for HIV Mtb co-infections, where activation arginase-1 due infection may promote survival replication both HIV. We utilized vitro systems determine how arginase inhibition using Nω-hydroxy-nor-L-arginine (nor-NOHA) alters pathway relative immune responses disease following infection. Treatment nor-NOHA polarized murine macrophages (RAW 264.7) towards M1 phenotype, increased NO, reduced RAW macrophages. In Balb/c mice, pulmonary metabolite spermine association a trend CFU lung. humanized system (HIS) plasma heightened response Mtb. cytokine Mtb/HIV lung tissue but did not significantly alter bacterial burden or viral load. Our results suggest modulators have as host-directed therapies augment antibiotics TB chemotherapy.

Язык: Английский

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[Changes and significance of oxidized phospholipids and endothelial nitric oxide synthase in the acute stage of Kawasaki disease].

PubMed, Год журнала: 2024, Номер 26(8), С. 829 - 834

Опубликована: Авг. 15, 2024

To investigate the changes in serum levels of oxidized phospholipids (OxPLs) and endothelial nitric oxide synthase (eNOS) their association with coronary artery disease (CAL) children acute stage Kawasaki (KD), as well clinical significance OxPLs eNOS.

Язык: Английский

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THE ROLE OF PHARMACOGENOMIC STUDIES IN INCREASING THE EFFECTIVENESS AND SAFETY OF CLINICAL APPLICATION OF STATINS

Clinical and Preventive Medicine, Год журнала: 2024, Номер 5, С. 109 - 123

Опубликована: Июль 18, 2024

Introduction. Currently, hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) are among the most widely used hypolipidemic drugs worldwide. However, to date, problems of insufficient effectiveness statin therapy and development unwanted side effects in patients remain not fully resolved. The identification key variants genes whose protein products involved metabolism their effect on carriers during may improve efficacy treatment help prevent effects, therefore be a valuable tool for clinicians when monitoring progress patients. whom these medicines were prescribed. Aim. To summarize information available literature that affect safety statins treatment. Materials methods. An assessment current role genetic was made. search performed Scopus, Web Science, Google Scholar, PubMed databases. Results. chemical structure described. review impact ABCB1, ABCG2, CYP3A4, CYP3A5, SLCO1B1 is presented. These have been shown associated with pharmacodynamics pharmacokinetics statins, which safe use. Conclusions. Since recent studies demonstrated influence transporters such as OATP BCRP, well cytochrome P450 system, further large-scale focusing drug needed. focused finding correlations between polymorphic encoding aforementioned CYP enzymes statins. presented data emphasize importance pharmacogenetic can useful minimize negative consequences taking who risk alleles.

Язык: Английский

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Pulse wave analysis as a tool to assess endothelial function following lipid lowering intervention in hypercholesterolemia

Microvascular Research, Год журнала: 2024, Номер unknown, С. 104772 - 104772

Опубликована: Ноя. 1, 2024

Язык: Английский

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