Harnessing the Potential of Exosomes in Therapeutic Interventions for Brain Disorders
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2491 - 2491
Опубликована: Март 11, 2025
Exosomes,
which
are
nano-sized
natural
vesicles
secreted
by
cells,
crucial
for
intercellular
communication
and
interactions,
playing
a
significant
role
in
various
physiological
pathological
processes.
Their
characteristics,
such
as
low
toxicity
immunogenicity,
high
biocompatibility,
remarkable
drug
delivery
capabilities—particularly
their
capacity
to
traverse
the
blood–brain
barrier—make
exosomes
highly
promising
vehicles
administration
treatment
of
brain
disorders.
This
review
provides
comprehensive
overview
exosome
biogenesis
isolation
techniques,
strategies
loading
functionalization
exosomes,
exosome-mediated
barrier
penetration
mechanisms,
with
particular
emphasis
on
recent
advances
exosome-based
Finally,
we
address
opportunities
challenges
associated
utilizing
system
brain,
summarizing
barriers
clinical
translation
proposing
future
research
directions.
Язык: Английский
Extracellular vesicles as therapeutic modulators of neuroinflammation in Alzheimer’s disease: a focus on signaling mechanisms
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Апрель 25, 2025
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
the
accumulation
of
amyloid-beta
(Aβ)
plaques
and
tau
tangles,
which
contribute
significantly
to
neuroinflammation,
central
driver
pathogenesis.
The
activation
microglia
astrocytes,
coupled
with
complex
interactions
between
Aβ
pathologies
innate
immune
response,
leads
cascade
inflammatory
events.
This
process
triggers
release
pro-inflammatory
cytokines
chemokines,
exacerbating
neuronal
damage
fostering
cycle
chronic
inflammation
that
accelerates
neurodegeneration.
Key
signaling
pathways,
such
as
nuclear
factor-kappa
B
(NF-κB),
Janus
kinase/signal
transducer
activator
transcription
(JAK/STAT),
mitogen-activated
protein
kinase
(MAPK),
phosphoinositide
3-kinase/protein
(PI3K/Akt),
are
involved
in
regulating
production
these
mediators,
offering
potential
therapeutic
targets
for
AD.
Recently,
extracellular
vesicles
(EVs)
have
emerged
promising
tool
AD
therapy,
due
their
ability
cross
blood-brain
barrier
(BBB)
deliver
agents.
Despite
challenges
standardizing
EV-based
therapies
ensuring
safety,
EVs
offer
novel
approach
modulating
neuroinflammation
promoting
neuroregeneration.
review
aims
highlight
intricate
relationship
emerging
role
therapeutics
advancing
treatment
strategies.
Язык: Английский
Role of Extracellular Vesicles in the Progression of Brain Tumors
Biology,
Год журнала:
2024,
Номер
13(8), С. 586 - 586
Опубликована: Авг. 2, 2024
Brain
tumors,
and,
in
particular,
glioblastoma
(GBM),
are
among
the
most
aggressive
forms
of
cancer.
In
spite
advancement
available
therapies,
both
diagnosis
and
treatments
still
unable
to
ensure
pathology-free
survival
GBM
patients
for
more
than
12–15
months.
At
basis
poor
ability
cope
with
brain
we
can
consider:
(i)
intra-tumor
heterogeneity;
(ii)
heterogeneity
tumor
properties
when
compare
different
patients;
(iii)
blood–brain
barrier
(BBB),
which
makes
difficult
isolation
tumor-specific
biomarkers
delivering
therapeutic
drugs
brain.
Recently,
it
is
becoming
increasingly
clear
that
cancer
cells
release
large
amounts
extracellular
vesicles
(EVs)
transport
metabolites,
proteins,
classes
RNAs,
DNA,
lipids.
These
structures
involved
pathological
process
characterize
any
particular
form
Moreover,
EVs
able
cross
BBB
directions.
Starting
from
these
observations,
researchers
now
evaluating
possibility
use
purified
organic
fluids
(first
all,
blood
saliva),
order
obtain,
through
non-invasive
methods
(liquid
biopsy),
biomarkers,
perhaps,
also
obtaining
nanocarriers
targeted
drugs.
Язык: Английский
Extracellular vesicles as delivery vehicles and therapeutic agents for glioblastoma treatment: A systematic review of in vitro and in vivo preclinical studies
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
unknown, С. 101043 - 101043
Опубликована: Март 1, 2025
Язык: Английский
Extracellular Vesicle-Based Drug Delivery Systems in Cancer Therapy
Jiahao Wu,
Z.X. Jin,
Tao Fu
и другие.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(10), С. 4835 - 4835
Опубликована: Май 19, 2025
Extracellular
vesicles
(EVs)
are
lipid
bilayer-enclosed
particles
secreted
by
cells
and
ubiquitously
present
in
various
biofluids.
They
not
only
mediate
intercellular
communication
but
also
serve
as
promising
drug
carriers
that
capable
of
delivering
therapeutic
agents
to
target
through
their
inherent
physicochemical
properties.
In
this
review,
we
summarized
the
recent
advances
EV
isolation
techniques
innovative
drug-loading
strategies.
Furthermore,
emphasized
distinct
advantages
applications
EVs
derived
from
different
cellular
sources
cancer
treatment.
Finally,
critically
evaluated
ongoing
clinical
trials
utilizing
for
delivery
systematically
assessed
both
opportunities
challenges
associated
with
implementing
EV-based
systems
therapy.
Язык: Английский
Isolation of Tumour‐Derived Extracellular Vesicles From the Plasma of Dogs Affected by Intracranial Tumours Showing Heterologous and Cross‐Species Tropism: A Pilot Study
Veterinary and Comparative Oncology,
Год журнала:
2024,
Номер
22(4), С. 621 - 628
Опубликована: Сен. 23, 2024
Canine
and
human
brain
tumours
exhibit
similar
incidence
rates
prognoses.
Recent
studies
have
demonstrated
that
extracellular
vesicles
derived
from
patients
(PDEVs)
can
be
loaded
with
contrast
agents
tumour
tropism
in
murine
models.
We
showed
a
previous
study
gadolinium-labelled
EVs
canine
gliomas
(cPDEVs)
selectively
targets
glioblastoma
cells
animal
As
further
step,
we
investigated
the
potential
heterologous
cross-species
of
cPDEVs
tumours.
With
perspective
imminent
clinical
application
as
both
markers
drug
delivery
tools,
successfully
established
isolation
protocol
for
confirmed
aseptic
conditions
procedure
therefore
sterility
isolated
EVs.
To
assess
functionality
tool,
they
were
indocyanine
green
(ICG)
injected
into
models
cancer
vivo
fluorescence
biodistribution
studies.
Biodistribution
analysis
mice
revealed
ICG-loaded
subcutaneous
accumulated
exclusively
neoplastic
tissue,
even
when
evaluated
24
h
post-injection,
thus
showing
selective
nanoparticles.
these
tests,
safe
isolating
loading
autologous
various
markers,
thereby
paving
way
testing
phase.
These
significant
findings
suggest
use
theranostic
tool
management
tumours,
promising
implications
translational
medicine
applications
future.
Язык: Английский