Neutrophil-targeted liposomal platform: A shift in novel approach for early detection and treatment of cancer metastasis DOI Creative Commons
Cong Li, Kexin Zhang,

Zehua Cheng

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(5), С. 100949 - 100949

Опубликована: Авг. 23, 2024

Tumor metastasis is responsible for 90% of cancer-associated deaths, and its early detection may decrease the likelihood mortality. Studies have demonstrated that results from interaction between "seeds" (tumor cells) "soil" (pre-metastatic niche, PMN). As first most abundant immune cells to be recruited PMN, neutrophils play a key role in ultimate formation metastatic foci through mechanisms such as supporting tumor cell growth, promoting angiogenesis, shaping an immune-suppressive microenvironment. In this study, two distinct types sialic acid (SA)-modified liposomes were prepared target regulate pro-metastatic l-selectin receptor. One these liposomes, named ICG@SAL, was used encapsulate indocyanine green (ICG) specifically designed cancer metastasis. The other liposome, referred ABE/Cur@SAL, co-loaded abemaciclib (ABE) curcumin (Cur), with intention suppressing progression tumor. Fluorescence imaging mouse spontaneous model indicated ICG@SAL faster targeting stronger accumulation organs than unmodified ICG (ICG@CL). This suggested could detect at stage. therapy experimental lung ABE/Cur@SAL inhibit regulatory T (Treg) proliferation, enhance effector activity reduce tumorigenic factor release, implying Overall, our work provided sensitive convenient approach diagnosis treatment employed metastasis, while development when identified.

Язык: Английский

STAT6 as a biomarker of trastuzumab resistance in patients with metastatic HER2-positive breast cancer DOI Creative Commons
О. І. Vynnychenko, Yuliia Moskalenko, Roman Moskalenko

и другие.

Український радіологічний та онкологічний журнал, Год журнала: 2025, Номер 33(1), С. 29 - 40

Опубликована: Март 31, 2025

Background. Breast cancer is the leading cause of cancer-related deaths among women worldwide, including in Ukraine. Transcription factors play a vital role normal development breast and may serve as potential biological markers to identify patients who are resistant trastuzumab. Purpose – investigate link between STAT6 expression effectiveness trastuzumab treatment with metastatic HER2-positive cancer. Materials Methods. The study involved 78 diagnosed inclusion criteria for included histologically immunohistochemically confirmed cancer, disease, trastuzumab, availability an archival tumor tissue sample, aged over 18 years, absence severe comorbidities that could lead death within next two years. Immunohistochemical analyses were performed on all samples using monoclonal rabbit antibodies against (clone EP325, Cell Marque, ready-to-use). Statistical analysis was conducted Stata V.18.0 software. Results. detected 71 out (91.0%). Among these, 33 (42.3%) exhibited low expression, while 38 (48.7%) had high expression. Loss expressions observed 7 (9.0%). Most did not have regional metastases (χ2 = 8.0451, p 0.018) low-grade tumors 5.9757, 0.048). loss majority experienced disease progression 53.3959, 0.0001). median progression-free survival low, 4.2, 14.1, 13.9 months, respectively (Log-rank Additionally, overall these groups 17.8, 31.4, 25.3 0.0002). Conclusions. In 9.0% exhibit linked resistance poorer rates.

Язык: Английский

Процитировано

0
The therapeutic potential of andrographolide in cancer treatment DOI Open Access

Jiaxuan Hu,

Yi Li, Xin Xie

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 180, С. 117438 - 117438

Опубликована: Сен. 19, 2024

Язык: Английский

Процитировано

3
Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages DOI Creative Commons
Yuchen Ma,

Xiaoli Qian,

Qun Yu

и другие.

Molecules, Год журнала: 2024, Номер 30(1), С. 123 - 123

Опубликована: Дек. 31, 2024

Inosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the effects inosine, particularly its ability to inhibit development colorectal cancer (CRC) cells CT26 through modulation macrophage phenotypes. Aside from already reported inosine on T cells, in this study, vitro experiments revealed that could modulate phenotype. The M1/M2 polarization were investigated at cellular level. Its role regulating CRC proliferation and migration was further examined. In addition, tumor mouse model established assess mechanism action by weight measurement, immunohistochemistry, immunofluorescence. significantly increased M1 markers CD86 iNOS enhanced anti-tumor activity macrophages, effectively inhibiting progression metastasis potential. vivo, had significant inhibitory activity. It also reduced expression Ki-67 promoted macrophages.

Язык: Английский

Процитировано

0
Macrophage subtypes inhibit breast cancer proliferation in culture DOI Creative Commons
Sophia R.S. Varady, Daniel Greiner, Minna Roh‐Johnson

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 1, 2024

Abstract Macrophages are a highly plastic cell type that adopt distinct subtypes and functional states depending on environmental cues. These can vary wildly, with macrophages capable of displaying opposing functions. We sought to understand how macrophage exist two ends spectrum influence the function other cells. used co-culture system primary human probe effects breast cancer proliferation. Our studies revealed surprising phenotype in which both inhibited proliferation compared cells alone. Of particular interest, using different assays lines, we showed differentiating into “pro-tumor” subtype findings inconsistent prevailing interpretation promote suggest re-evaluation these interpretations made.

Язык: Английский

Процитировано

0
Neutrophil-targeted liposomal platform: A shift in novel approach for early detection and treatment of cancer metastasis DOI Creative Commons
Cong Li, Kexin Zhang,

Zehua Cheng

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(5), С. 100949 - 100949

Опубликована: Авг. 23, 2024

Tumor metastasis is responsible for 90% of cancer-associated deaths, and its early detection may decrease the likelihood mortality. Studies have demonstrated that results from interaction between "seeds" (tumor cells) "soil" (pre-metastatic niche, PMN). As first most abundant immune cells to be recruited PMN, neutrophils play a key role in ultimate formation metastatic foci through mechanisms such as supporting tumor cell growth, promoting angiogenesis, shaping an immune-suppressive microenvironment. In this study, two distinct types sialic acid (SA)-modified liposomes were prepared target regulate pro-metastatic l-selectin receptor. One these liposomes, named ICG@SAL, was used encapsulate indocyanine green (ICG) specifically designed cancer metastasis. The other liposome, referred ABE/Cur@SAL, co-loaded abemaciclib (ABE) curcumin (Cur), with intention suppressing progression tumor. Fluorescence imaging mouse spontaneous model indicated ICG@SAL faster targeting stronger accumulation organs than unmodified ICG (ICG@CL). This suggested could detect at stage. therapy experimental lung ABE/Cur@SAL inhibit regulatory T (Treg) proliferation, enhance effector activity reduce tumorigenic factor release, implying Overall, our work provided sensitive convenient approach diagnosis treatment employed metastasis, while development when identified.

Язык: Английский

Процитировано

0