Disulfidptosis: A new type of cell death
APOPTOSIS,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 17, 2024
Abstract
Disulfidptosis
is
a
novel
form
of
cell
death
that
distinguishable
from
established
programmed
pathways
such
as
apoptosis,
pyroptosis,
autophagy,
ferroptosis,
and
oxeiptosis.
This
process
characterized
by
the
rapid
depletion
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
in
cells
high
expression
solute
carrier
family
7
member
11
(SLC7A11)
during
glucose
starvation,
resulting
abnormal
cystine
accumulation,
which
subsequently
induces
andabnormal
disulfide
bond
formation
actin
cytoskeleton
proteins,
culminating
network
collapse
disulfidptosis.
review
aimed
to
summarize
underlying
mechanisms,
influencing
factors,
comparisons
with
traditional
pathways,
associations
related
diseases,
application
prospects,
future
research
directions
Язык: Английский
Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment
Nadi Rostami Ravari,
Farzad Sadri,
Mohammad Ali Mahdiabadi
и другие.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 26, 2025
Lung
cancer
(LC)
is
a
highly
prevalent
and
deadly
type
of
characterized
by
intricate
molecular
pathways
that
drive
tumor
development,
metastasis,
resistance
to
conventional
treatments.
Recently,
ferroptosis,
controlled
mechanism
cell
death
instigated
iron-dependent
lipid
peroxidation,
has
gained
attention
for
its
role
in
LC
progression
treatment.
Noncoding
RNAs
(ncRNAs),
such
as
microRNAs
(miRNAs)
long
noncoding
(lncRNAs),
are
emerging
key
modulators
significantly
influencing
biology.
This
review
explores
how
ncRNAs
control
ferroptotic
affect
growth,
therapy
LC.
By
understanding
the
dual
functions
both
activating
inhibiting
we
aim
uncover
new
therapeutic
targets
strategies
These
insights
provide
promising
direction
development
ncRNA-based
treatments
designed
induce
potentially
improving
outcomes
patients
with
Язык: Английский
Absence of Cysteine and Iron Chelation Induces Ferroptosis in Triple-Negative Breast Cancer Cells
Breast Cancer Basic and Clinical Research,
Год журнала:
2025,
Номер
19
Опубликована: Янв. 1, 2025
Background:
Ferroptosis
is
a
recently
studied
form
of
programmed
cell
death
characterized
by
lipid
peroxides
accumulation
in
the
cells.
This
process
occurs
when
cell’s
antioxidant
capacity
disturbed
resulting
inability
to
detoxify
toxic
peroxides.
Two
major
components
that
regulate
ferroptosis
are
cysteine
and
iron.
Objective:
study
aimed
determine
effect
deficiency
iron
chelation
on
triple-negative
breast
cancer
(TNBC)
lipid-enriched
microenvironment.
Design:
The
has
laboratory-based
experimental
design.
used
MDA-MB-231
line
various
vitro
culture
systems
investigate
research
question.
Methods:
For
first
part
study,
we
subjected
cells
grow
cysteine-absent
adipocyte-conditioned
media.
In
second
half,
treated
with
chelator,
deferoxamine.
BODIPY
imaging
western
blot
were
carried
out
observe
under
2
conditions.
Results:
results
showed
absence
conditioned
media
was
able
reduce
formation
droplets,
which
increased
greater
access
free
fatty
acids
undergo
oxidation,
therefore
inducing
ferroptosis.
On
contrary,
deferoxamine
along
erastin
(ferroptosis-inducing
drug),
an
increase
content
observed,
later
Conclusion:
Our
show
alternative
function
deferoxamine,
one
regulating
droplets
other
ferroptosis,
although
inhibitor
same,
respectively.
Язык: Английский
Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 7, 2025
Introduction
Chondrocyte
ferroptosis
is
an
important
component
of
the
pathogenesis
osteoarthritis.
Paeonol,
main
pharmacologically
active
ingredient
Paeonia
suffruticosa
Andrews,
a
natural
radical
scavenger
with
potent
biological
activities,
including
antioxidant,
anti-inflammatory,
and
cartilage
protection
effects.
However,
molecular
mechanisms
underlying
its
role
in
regulating
chondrocytes
remain
unclear.
Methods
To
investigate
effect
paeonol
on
inflammation
through
interleukin-1β
(IL-1β),
proliferation
activity,
lipid
peroxidation
level,
endogenous
antioxidant
capacity,
mitochondrial
membrane
potential
were
evaluated
detail.
Intracellular
ferrous
ion
concentration
was
detected
by
FerroOrange
fluorescent
probe
staining.
Western
blotting
immunofluorescence
staining
used
to
detect
biomarker
proteins
ferroptosis,
inflammation,
AMPK/Nrf2/GPX4
signaling
pathway
proteins.
Results
The
results
showed
that
significantly
depressed
IL-1β-induced
chondrocytes.
Specifically,
protects
cell
viability,
reduces
damage,
maintains
function,
inhibits
pro-ferroptosis
pro-inflammation
In
addition,
anti-inflammatory
ability
partially
inhibited
after
addition
agonist
erastin,
suggesting
against
inflammatory
injury
part
inhibiting
ferroptosis.
Further
studies
activated
AMPK
phosphorylation
promoted
Nrf2
nuclear
translocation
Keap1
degradation.
Finally,
AMPK-Nrf2-GPX4
confirmed
be
mechanism
simultaneous
use
inhibitor.
Conclusion
These
indicate
chondrocytes,
partly
axis.
Язык: Английский
Targeting endothelial cells: A novel strategy for pulmonary fibrosis treatment
European Journal of Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 177472 - 177472
Опубликована: Март 1, 2025
Язык: Английский
The role of ferroptosis-related non-coding RNA in liver fibrosis
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 9, 2024
Liver
fibrosis
represents
a
reversible
pathophysiological
process,
caused
by
chronic
inflammation
stemming
from
hepatocyte
damage.
It
delineates
the
initial
stage
in
progression
of
liver
disease.
This
pathological
is
characterized
excessive
accumulation
extracellular
matrix
(ECM),
which
leads
to
significant
structural
disruption
and
ultimately
impairs
function.
To
date,
no
specific
antifibrotic
drugs
have
been
developed,
advanced
remains
largely
incurable.
transplantation
sole
efficacious
intervention
for
fibrosis;
nevertheless,
it
constrained
exorbitant
costs
risk
postoperative
immune
rejection,
underscoring
imperative
novel
therapeutic
strategies.
Ferroptosis,
an
emergent
form
regulated
cell
death,
has
identified
as
pivotal
regulatory
mechanism
development
intricately
linked
with
diseases.
Recent
investigations
elucidated
that
diverse
array
non-coding
RNAs
(ncRNAs),
including
microRNAs,
long
RNAs,
circular
are
involved
ferroptosis
pathway,
thereby
modulating
various
diseases,
fibrosis.
In
recent
years,
roles
ferroptosis-related
ncRNAs
attracted
escalating
scholarly
attention.
paper
elucidates
pathophysiology
fibrosis,
explores
mechanisms
underlying
ferroptosis,
involvement
ncRNA-mediated
pathways
pathology
aims
propose
strategies
prevention
Язык: Английский