Research progress on the regulatory and pharmacological mechanism of chemical components of Dendrobium
Heliyon,
Год журнала:
2024,
Номер
10(18), С. e37541 - e37541
Опубликована: Сен. 1, 2024
Язык: Английский
Future Research Directions for Dendrobium nobile
CABI eBooks,
Год журнала:
2025,
Номер
unknown, С. 255 - 272
Опубликована: Март 24, 2025
Язык: Английский
Analgesic and Anti-inflammatory Properties of Dendrobium nobile
CABI eBooks,
Год журнала:
2025,
Номер
unknown, С. 118 - 142
Опубликована: Март 24, 2025
Язык: Английский
A Dendrobium chrysotoxum extract erianin induce AML cells death by activating PPARɑ and downregulating PI3K/AKT signaling pathways
Toxicon,
Год журнала:
2025,
Номер
261, С. 108371 - 108371
Опубликована: Апрель 23, 2025
Язык: Английский
Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7973 - 7973
Опубликована: Июль 21, 2024
Erianin,
a
bibenzyl
compound
found
in
dendrobium
extract,
has
demonstrated
broad
anticancer
activity.
However,
its
mechanism
of
action
gastric
cancer
(GC)
remains
poorly
understood.
Язык: Английский
Design, synthesis and antitumor activity of novel 4-oxobutanamide derivatives
Caiju Wu,
Jingliang He,
Hanxue Li
и другие.
Bioorganic & Medicinal Chemistry Letters,
Год журнала:
2024,
Номер
113, С. 129978 - 129978
Опубликована: Сен. 26, 2024
Язык: Английский
Erianin suppresses the development of acute myeloid leukemia via PPARɑ and regulating PI3K/AKT signaling pathways
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
Abstract
Acute
myelogenous
leukemia
is
a
highly
invasiveness
hematological
malignancies
that
mainly
relies
on
chemotherapy
to
improve
survival
rate
at
present.Up
now,the
application
of
natural
products
has
been
widely
accepted
as
an
alternative
compared
with
conventional
chemotherapeutic
agents
due
their
relative
safety.In
our
research,we
attempted
explore
the
anti-AML
capacity
and
potential
mechanism
Erianin(Eri),
component
from
Chinese
herbal
medicine
Dendrobium
flaviflorum.We
verified
Erianin
inhibited
proliferation
AML
cells
induced
apoptosis.Erianin
can
block
cell
cycle
G2/M
phase
thourgh
regulation
cycle-related
proteins
P21,P27,P53
mRNA
expression.Mechanistically,
we
firstly
filtered
locked
PPARɑ
PIK3R1
through
network
pharmacology
analysis,
protein-protein
interaction
(PPI)
network,
GO
KEGG
pathway
enrichment
further
confirmed
good
binding
by
molecular
docking.Specifically,Erianin
transcriptional
level
activating
protein
PPARɑ,
thereby
inhibiting
PI3K/AKT
pathway.The
inhibitory
ability
was
partially
neutralized
GW6471,an
inhibitor
PPARɑ.It
also
worth
noting
revealed
vigoroso
coordinate
repression
LY294002
cells.
Overall,
these
evidences
indicated
exerted
influence
least
regulate
signaling
pathways.In
summarize,
demonstrated
potent
effect
mechanisms
Erianin,
which
suggested
hopeful
strategy
be
developed
into
novel
drug.
Язык: Английский
In situ identification of gastroprotective components from Dendrobium huoshanense using magnetic nanoparticles combined with biomaterials assisted EFISI-MS
P. Zhang,
Yuwen Guo,
Yuxing Xu
и другие.
Talanta,
Год журнала:
2024,
Номер
283, С. 127163 - 127163
Опубликована: Ноя. 6, 2024
Язык: Английский
Biological Characteristics of a Novel Bibenzyl Synthase (DoBS1) Gene from Dendrobium officinale Catalyzing Dihydroresveratrol Synthesis
Molecules,
Год журнала:
2024,
Номер
29(22), С. 5320 - 5320
Опубликована: Ноя. 12, 2024
Bibenzyl
compounds
are
one
of
the
most
important
bioactive
components
natural
medicine.
However,
Язык: Английский