The targeting of YAP by kaempferol regulates bone homeostasis and improves osteoporosis in rats

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский

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Exosome-Derived Uc.339 as a Potential Biomarker for Bone Metastasis from Pulmonary Adenocarcinoma

Tissue and Cell, Год журнала: 2025, Номер 93, С. 102747 - 102747

Опубликована: Янв. 18, 2025

Язык: Английский

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Rational engineering of an optimized near-infrared fluorogenic sensor for efficient discovery of potent Notum inhibitors as anti-osteoporosis agents

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137427 - 137427

Опубликована: Фев. 1, 2025

Язык: Английский

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Kaempferol promotes angiogenesis through HIF-1α/VEGF-A/Notch1 pathway in ischemic stroke rats

Neurochemistry International, Год журнала: 2025, Номер 185, С. 105953 - 105953

Опубликована: Фев. 21, 2025

Язык: Английский

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Prospective and challenges of locally applied repurposed pharmaceuticals for periodontal tissue regeneration

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Ноя. 13, 2024

Periodontitis is a persistent inflammatory condition that causes periodontal ligament degradation, pocket development, and alveolar bone destruction, all of which lead to the breakdown teeth’s supporting system. triggered by accumulation various microflora (especially anaerobes) in pockets, release toxic substances digestive enzymes stimulate immune can be efficiently treated using variety techniques, both regional systemic. Effective therapy dependent on lowering microbial biofilm, minimizing or eradicating pockets. Nowadays, local drug delivery systems (LDDSs) as an adjuvant phase I attractive option since it controls release, resulting improved efficacy lesser adverse reactions. Choosing right bioactive agent mode foundation efficient disease management approach. The objective this paper shed light issue successful regeneration, drawbacks currently implemented interventions, describe potential locally delivered repurposed drugs tissue regeneration. Because multiple etiology periodontitis, patients must get customized treatment with primary goal infection control. Yet, not always replace lost tissues, becomes more challenging defect gets worse. Pharmaceutical repurposing offers viable, economical, safe alternative for non-invasive, predictable This article clears way front researchers, decision-makers, pharmaceutical companies explore potential, effectiveness, efficiency pharmaceuticals generate effective, topical preparations

Язык: Английский

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Hydrolyzed egg yolk peptide alleviates ovariectomy-induced osteoporosis by regulating lipid metabolism

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 292, С. 139223 - 139223

Опубликована: Дек. 27, 2024

Язык: Английский

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Bone marrow derived mesenchymal stem cells restored GLUT1 expression in the submandibular salivary glands of ovariectomized rats

Archives of Oral Biology, Год журнала: 2024, Номер 166, С. 106048 - 106048

Опубликована: Июль 13, 2024

Язык: Английский

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