Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies
Cells,
Год журнала:
2024,
Номер
13(16), С. 1354 - 1354
Опубликована: Авг. 14, 2024
Autophagy,
an
evolutionarily
conserved
cellular
mechanism
essential
for
maintaining
internal
stability,
plays
a
crucial
function
in
female
reproductive
ability.
In
this
review,
we
discuss
the
complex
interplay
between
autophagy
and
several
facets
of
health,
encompassing
pregnancy,
ovarian
functions,
gynecologic
malignancies,
endometriosis,
infertility.
Existing
research
emphasizes
significance
embryo
implantation,
specifically
endometrium,
highlighting
its
necessity
ensuring
proper
fetal
development.
Although
some
knowledge
has
been
gained,
there
is
still
lack
on
specific
molecular
impacts
quality
oocytes,
growth
follicles,
general
health.
Autophagy
role
maturation,
quality,
development
oocytes.
It
also
involved
aging,
contributing
to
reductions
that
occur
with
age.
This
review
explores
physiological
functions
system,
participation
toxicity,
important
connections
endometrium
embryo.
addition,
study
investigates
possibility
emerging
treatment
approaches
aim
modify
autophagy,
using
both
natural
substances
synthetic
molecules,
improve
fertility
outcomes.
Additionally,
intends
inspire
future
exploration
into
intricate
health
by
reviewing
recent
studies
pinpointing
areas
where
current
lacking.
Subsequent
investigations
should
prioritize
conversion
these
discoveries
practical
uses
medical
field,
which
could
potentially
result
groundbreaking
therapies
infertility
other
difficulties
related
reproduction.
Therefore,
gaining
comprehensive
understanding
many
effects
would
not
only
further
field
biology
but
open
new
possibilities
diagnostic
methods.
Язык: Английский
Emerging Role of Hypoxia-Inducible Factors (HIFs) in Modulating Autophagy: Perspectives on Cancer Therapy
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1752 - 1752
Опубликована: Фев. 19, 2025
Hypoxia-inducible
factors
(HIFs)
are
master
regulators
of
cellular
responses
to
low
oxygen
levels
and
modulate
autophagy,
a
conserved
process
essential
for
maintaining
homeostasis.
Under
hypoxic
conditions,
HIFs
regulate
the
expression
autophagy-related
genes
influence
autophagic
flux
stress
responses.
Dysregulated
hypoxia-induced
autophagy
promotes
cancer
cell
survival,
metabolism,
metastasis,
thereby
contributing
treatment
resistance.
Targeting
HIF-mediated
pathways
or
modulating
processes
offers
potential
improve
traditional
therapies
overcome
drug
Pharmacological
inhibitors
either
alone
in
combination
with
other
treatments,
may
disrupt
pro-survival
mechanisms
within
tumor
microenvironment.
Further
research
is
needed
elucidate
intricate
interplay
between
HIF
signaling
machinery
cells.
Understanding
these
could
pave
way
novel
therapeutic
strategies
enhance
outcomes
combat
This
review
highlights
complex
relationship
development
therapy,
offering
insights
into
how
targeting
patient
outcomes.
Язык: Английский
Advancements in Autophagy Modulation for the Management of Oral Disease: A Focus on Drug Targets and Therapeutics
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2645 - 2645
Опубликована: Ноя. 19, 2024
Autophagy
is
an
intrinsic
breakdown
system
that
recycles
organelles
and
macromolecules,
which
influences
metabolic
pathways,
differentiation,
thereby
cell
survival.
Oral
health
essential
component
of
integrated
well-being,
it
critical
for
developing
therapeutic
interventions
to
understand
the
molecular
mechanisms
underlying
maintenance
oral
homeostasis.
However,
because
complex
dynamic
relationship
between
autophagy
health,
associated
treatment
modalities
have
not
yet
been
well
elucidated.
Determining
how
affects
at
level
may
enhance
understanding
prevention
targeted
diseases.
At
level,
hard
soft
tissues
develop
interactions
epithelial
mesenchymal
cells.
Aging
contributes
progression
various
disorders
including
periodontitis,
cancer,
periapical
lesions
during
aging.
levels
decrease
with
age,
thus
indicating
a
possible
association
In
this
review,
we
critically
review
aspects
their
significance
in
context
diseases
lesions,
periodontal
conditions,
candidiasis.
A
better
its
can
guide
us
new
preventative
strategies
management
Язык: Английский
Folic-Acid-Conjugated Poly (Lactic-Co-Glycolic Acid) Nanoparticles Loaded with Gallic Acid Induce Glioblastoma Cell Death by Reactive-Oxygen-Species-Induced Stress
Polymers,
Год журнала:
2024,
Номер
16(15), С. 2161 - 2161
Опубликована: Июль 30, 2024
Glioblastoma
(GBM)
conventional
treatment
is
not
curative,
and
it
associated
with
severe
toxicity.
Thus,
natural
compounds
anti-cancer
properties
lower
systemic
toxicity,
such
as
gallic
acid
(GA),
have
been
explored
alternatives.
However,
GA’s
therapeutic
effects
are
limited
due
to
its
rapid
metabolism,
low
bioavailability,
permeability
across
the
blood–brain
barrier
(BBB).
This
work
aimed
develop
poly
(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(NPs)
modified
folic
(FA),
receptor
overexpressed
in
BBB
GBM
cells,
for
GA
delivery
enhance
efficacy.
The
preparation
of
NPs
was
optimized
by
a
central
composite
design
(CCD).
obtained
showed
physicochemical
features
suitable
drug
internalization
tumor
cells
(sizes
below
200
nm,
monodispersity,
negative
surface
charge)
ability
maintain
slow
sustained
release
40
days.
In
vitro
studies
using
human
cell
line
(U215)
revealed
NPs’
accumulate
target
further
promoting
antiproliferative
activity
inducing
production
intracellular
reactive
oxygen
species
(ROS).
Furthermore,
encapsulation
developed
nanosystems
conferred
higher
protection
healthy
cells.
Язык: Английский
Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2405 - 2405
Опубликована: Окт. 21, 2024
Apigenin
is
an
organic
flavonoid
abundant
in
some
plants
such
as
parsley,
chamomile,
or
celery.
Recently,
it
has
been
investigated
for
several
of
its
pharmacological
characteristics,
ability
to
act
antioxidant,
reduce
inflammation,
and
inhibit
the
growth
cancer
cells.
The
purpose
this
review
provide
a
summary
existing
knowledge
regarding
effects
apigenin
on
female
reproductive
systems
dysfunctions.
can
influence
processes
by
regulating
multiple
biological
events,
including
oxidative
processes,
cell
proliferation,
apoptosis,
renewal
viability,
ovarian
blood
supply,
release
hormones.
It
could
stimulate
folliculogenesis,
well
embryonal
proliferation
which
lead
increase
fertility
hormones,
may
exert
health.
Furthermore,
activities
cells
alleviate
pathological
changes
system
caused
environmental
pollutants,
harmful
medications,
cancer,
polycystic
syndrome,
ischemia,
endometriosis.
Therefore,
have
potential
biostimulator
therapeutic
agent
certain
diseases.
Язык: Английский
In‐silico and In‐vitro Investigation of Flavonoids and Alkaloids from Artocarpus heterophyllus, Tinospora cordifolia, and Glycosmis pentaphylla as Potential NF‐κB Inhibitors in Oral Cancer
Komal Nagesh Gotsurve,
Joyeeta Das,
Suraj Kutre
и другие.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Abstract
Oral
cancer
is
a
global
health
concern,
particularly
because
of
its
aggressive
tissue
invasion
and
metastases,
holding
16
th
position
on
occurrence
among
all
carcinoma
worldwide.
The
aberrated
transcription
factor
NF‐
κ
B1
influences
development
spread
oral
cancer,
making
it
potential
therapeutic
target.
This
study
investigated
the
few
natural
compounds
from
Artocarpus
heterophyllus
,
Tinospora
cordifolia
Glycosmis
pentaphylla
in
treatment
cancer.
Two
FDA‐approved
drugs
(5‐fluorouracil,
Docetaxel)
compounds,
including
Artocarpin,
Artocarpanone,
Cycloartocarpin
;
Berberine,
Hydrastine,
Magnoflorine,
Palmatine
Chloride,
Tetrahydropalmatine
5‐Hydroxyarborinine,
5‐Hydroxynoracronycine,
1‐Hydroxy‐3‐methoxy‐10‐methyl‐9‐acridone,
Des‐N‐methylacronycine,
Des‐N‐methylnoracronycine,
Kokusagenine,
Noracronycin,
Skimmianine
were
examined
using
in‐silico
techniques.
Among
studied,
Hydrastine
shown
highest
binding
energy
(−6.87
kcal/mol)
against
B1,
surpassing
other
drugs,
standards
5‐fluorouracil
(−4.04
docetaxel
(−2.4
kcal/mol).
Further
molecular
dynamics
simulations
in‐vitro
experiments
verified
Hydrastine's
exceptional
anti‐cancer
activity.
results
well‐aligned
with
findings
revealing
considerable
cytotoxicity,
apoptosis
induction,
cell
cycle
arrest.
revealed
compounds’
as
safer,
more
effective
alternatives
to
current
therapeutics,
opening
up
new
avenues
for
treatment.
Язык: Английский
Neurotrophic Effects of Foeniculum vulgare Ethanol Extracts on Hippocampal Neurons: Role of Anethole in Neurite Outgrowth and Synaptic Development
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12701 - 12701
Опубликована: Ноя. 26, 2024
Foeniculum
vulgare
Mill,
commonly
known
as
fennel,
is
an
aromatic
herb
traditionally
used
for
culinary
and
medicinal
purposes,
with
potential
therapeutic
effects
on
neurological
disorders.
However,
limited
research
has
focused
its
neurotrophic
impact,
particularly
neuronal
maturation
synaptic
development.
This
study
investigates
the
of
F.
ethanol
extracts
(FVSE)
rat
primary
hippocampal
neurons.
Results
show
that
FVSE
prominent
component,
anethole,
significantly
promote
neurite
outgrowth
in
a
dose-dependent
manner.
Optimal
axonal
dendritic
growth
occurred
at
concentrations
40
µg/mL
20
µM
respectively,
without
causing
cytotoxicity,
underscoring
safety
health.
Additionally,
enhances
formation
synapses,
essential
communication.
Network
pharmacology
analysis
revealed
components
influence
critical
pathways,
including
PI3K-AKT
Alzheimer’s
disease
pathways.
Specifically,
modulates
key
proteins,
tropomyosin
receptor
kinase
(Trk),
glycogen
synthase
3
(GSK3βser9),
phosphatidylinositol
3-kinase
(PI3K),
extracellular
signal-regulated
protein
(Erk1/2).
Anethole
was
found
to
play
role
regulating
these
which
confirmed
by
immunocytochemistry
experiments
demonstrating
effect
promoting
In
conclusion,
this
highlights
properties
FVSE,
anethole
emerging
bioactive
compound.
These
findings
provide
valuable
insights
into
fennel
treating
disorders,
offering
basis
future
interventions
survival.
Язык: Английский