Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Год журнала:
2025,
Номер
unknown, С. 167791 - 167791
Опубликована: Март 1, 2025
Kidney
stones
represent
a
highly
prevalent
urological
disorder
worldwide,
with
high
incidence
and
recurrence
rates.
Calcium
oxalate
(CaOx)
crystal-induced
kidney
injury
serves
as
the
foundational
mechanism
for
formation
progression
of
CaOx
stones.
Regulated
cell
death
(RCD)
such
ferroptosis,
necroptosis,
pyroptosis
are
essential
in
pathophysiological
process
injury.
Ferroptosis,
newly
discovered
RCD,
is
characterized
by
its
reliance
on
iron-mediated
lipid
peroxidation.
Necroptosis,
widely
studied
programmed
necrosis,
initiates
necrotic
phenotype
that
resembles
apoptosis
appearance.
Pyroptosis,
type
RCD
involves
gasdermin
protein,
accompanied
inflammation
immune
response.
In
recent
years,
increasing
amounts
evidence
has
demonstrated
significant
processes
involved
Herein,
we
summed
up
roles
Furthermore,
delved
into
curative
potential
targeting
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 28, 2025
CircRNAs
are
closely
related
to
ferroptosis
in
gastric
cancer
cells;
however,
the
mechanism
by
which
circRNAs
regulate
carcinogenesis
remains
unknown.
CircRNA-encoded
novel
peptides
functional
products
translated
from
open
reading
frames
(ORFs)
within
circular
RNAs,
demonstrating
that
not
only
serve
as
non-coding
regulators
but
also
have
capacity
encode
biologically
active
peptides.
Compared
with
noncancerous
cells,
cells
greater
iron
requirements,
and
occurs
response
radiotherapy,
chemotherapy,
immunotherapy;
therefore,
activation
may
be
a
potential
strategy
overcome
shortcomings
of
conventional
therapy.
A
mouse
model
was
constructed,
bioinformatics
analysis
performed
analyze
characterize
involved
cancer.
The
inhibitory
effect
hsa_circ_0002301
on
tumors
confirmed
both
vitro
vivo.
presence
expression
HECTD1-463aa
were
verified
using
mass
spectrometry,
protein
blotting,
immunofluorescence
staining.
molecular
investigated
spectrometry
immunoprecipitation.
We
designed
synthesized
antibodies
specific
for
small
encoded
verify
its
purified
constructing
overexpression
vectors
FLAG
tags
used
liquid
chromatography–tandem
(LC‒MS/MS)
detect
characterized
In
addition,
HECTD1
binding
identified
immunoprecipitation
(Co-IP)
spectrometry.
found
inhibited
HECTD1-mediated
GPX4
ubiquitination
HECTD1,
an
important
regulator
cell
death
ferroptotic
cells.
competitively
inhibits
degradation
through
proteins
affect
level
Molecules,
Год журнала:
2025,
Номер
30(6), С. 1211 - 1211
Опубликована: Март 8, 2025
Neurodegenerative
diseases
are
a
group
of
that
share
common
features,
such
as
the
generation
misfolded
protein
deposits
and
increased
oxidative
stress.
Among
them,
amyotrophic
lateral
sclerosis
(ALS),
whose
pathogenesis
is
still
not
entirely
clear,
complex
neurodegenerative
disease
linked
both
to
gene
mutations
affecting
different
proteins,
superoxide
dismutase
1,
Tar
DNA
binding
43,
Chromosome
9
open
frame
72,
Fused
in
Sarcoma,
altered
iron
homeostasis,
mitochondrial
dysfunction,
stress,
impaired
glutamate
metabolism.
The
purpose
this
review
highlight
molecular
targets
ALS
ferroptosis.
Indeed,
many
pathways
implicated
hallmarks
ferroptosis,
recently
discovered
type
iron-dependent
programmed
cell
death
characterized
by
reactive
oxygen
species
(ROS)
lipid
peroxidation.
Iron
accumulation
results
dysfunction
levels
ROS,
peroxidation,
ferroptosis
triggers;
addition,
inhibition
Xc−
system
reduced
cystine
accumulation,
leading
excitotoxicity
GPx4
synthesis.
These
potential
involvement
ALS,
providing
new
biochemical
could
be
exploited
treatment
using
polyphenols.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Год журнала:
2025,
Номер
unknown, С. 167791 - 167791
Опубликована: Март 1, 2025
Kidney
stones
represent
a
highly
prevalent
urological
disorder
worldwide,
with
high
incidence
and
recurrence
rates.
Calcium
oxalate
(CaOx)
crystal-induced
kidney
injury
serves
as
the
foundational
mechanism
for
formation
progression
of
CaOx
stones.
Regulated
cell
death
(RCD)
such
ferroptosis,
necroptosis,
pyroptosis
are
essential
in
pathophysiological
process
injury.
Ferroptosis,
newly
discovered
RCD,
is
characterized
by
its
reliance
on
iron-mediated
lipid
peroxidation.
Necroptosis,
widely
studied
programmed
necrosis,
initiates
necrotic
phenotype
that
resembles
apoptosis
appearance.
Pyroptosis,
type
RCD
involves
gasdermin
protein,
accompanied
inflammation
immune
response.
In
recent
years,
increasing
amounts
evidence
has
demonstrated
significant
processes
involved
Herein,
we
summed
up
roles
Furthermore,
delved
into
curative
potential
targeting
