Application of cell therapy in rheumatoid Arthritis: Focusing on the immunomodulatory strategies of Mesenchymal stem cells
International Immunopharmacology,
Год журнала:
2025,
Номер
147, С. 114017 - 114017
Опубликована: Янв. 7, 2025
Язык: Английский
Mesenchymal Stromal Cell-Based Therapy: A Promising Approach for Autoimmune Diseases
Clinical Reviews in Allergy & Immunology,
Год журнала:
2025,
Номер
68(1)
Опубликована: Фев. 21, 2025
Язык: Английский
Extracellular vesicles as therapeutic agents in rheumatoid arthritis: a systematic review of current evidence
Xiaolei Miao,
Amirreza Ghafourian,
Mahdi Karimi Khaneghah
и другие.
Inflammopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Apigenin protects ischemic stroke by regulating intestinal microbiota homeostasis, regulates brain metabolic profile
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 7, 2025
Background
and
Objective
Ischemic
stroke
is
a
cerebrovascular
disease
with
highly
incidence.
Previous
research
has
demonstrated
that
apigenin
provides
protective
effects
against
ischemic
stroke.
However,
it
remains
unclear
whether
can
regulate
intestinal
flora
Methods
In
this
study,
we
evaluated
the
regulatory
of
on
microbiota
using
middle
cerebral
artery
occlusion
rat
model.
The
impact
brain
damage
in
rats
was
assessed
through
Nissl
staining,
hematoxylin
eosin
immunohistochemistry.
Additionally,
employed
16S
rRNA
sequencing
to
analyze
contents
utilized
non-targeted
metabolomics
investigate
metabolites,
thereby
exploring
its
mechanism
action.
AMPK
levels
were
detected
by
Western
blot
kit
used
detect
oxidative
stress
inflammation.
Results
intervention
resulted
significant
alterations
flora,
characterized
an
increase
abundance
probiotic
species
decrease
harmful
alongside
notable
changes
metabolite
profiles.
This
effect
attributed
apigenin’s
promotion
expression
enhancement
energy
metabolism
context
addition,
improved
inflammation
Conclusion
These
findings
suggest
exerts
signaling
pathway
modulating
associated
metabolites.
Consequently,
emerges
as
therapeutic
candidate
warranting
further
investigation.
Язык: Английский
Pretreatment of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes with Quercetin Enhances the Healing of Diabetic Skin Wounds by Modulating Host-Microbiota Interactions
Shuhui Wu,
Zhongsheng Zhou,
Yang Li
и другие.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12557 - 12581
Опубликована: Ноя. 1, 2024
Owing
to
the
distinctive
advantages
of
mesenchymal
stem
cell-derived
exosomes
(MSCs-exo),
these
vesicles
have
emerged
as
a
pivotal
research
focus
in
regenerative
medicine,
surpassing
their
MSC
counterparts.
Quercetin
(Qr),
widely
recognized
for
its
potent
anti-inflammatory
and
antioxidant
activities,
demonstrates
substantial
potential
enhancing
tissue
repair
processes.
This
study
delves
into
role
quercetin-pretreated
MSC-derived
(MSCs
Язык: Английский