El gen estimulado por interferón 15 (ISG15) modula el fenotipo de células musculares lisas vasculares y el remodelado vascular patológico

Clínica e Investigación en Arteriosclerosis, Год журнала: 2025, Номер unknown, С. 500769 - 500769

Опубликована: Фев. 1, 2025

Язык: Английский

Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction

Basic & Clinical Pharmacology & Toxicology, Год журнала: 2025, Номер 136(5)

Опубликована: Март 31, 2025

ABSTRACT Excessive local inflammation is a common mechanism in many cardiovascular diseases (CVDs) such as hypertension, atherosclerosis and aortic aneurysms. In endothelial cells, inflammatory cytokines interferons, tumour necrosis factor alpha or interleukins increase oxidative stress contractile prostanoids the expression of adhesion molecules that reduce nitric oxide (NO) availability bind leucocytes, thereby impairing function. Despite this evidence, anti‐inflammatory therapies are not yet indicated for treatment most CVD. Resolution mediated by family specialized pro‐resolving mediators (SPMs) act on cognate G protein–coupled receptors to limit immune cell infiltration initiate tissue repair. SPMs, generated from omega‐3 omega‐6 polyunsaturated fatty acids, belong four major families: lipoxins, resolvins, protectins maresins. SPM expressed vascular cells where they regulate important processes phagocytosis polarization, production cytokines, NO prostacyclin, modulation smooth muscle phenotype. Growing evidence animal models demonstrates activation can protect function structure provide beneficial effects various We will review recent advances role SPMs (dys)function atherosclerosis,

Язык: Английский

Continuous infusion of Resolvin D2 in combination with Angiotensin-II show contrary effects on blood pressure and intracardiac artery remodeling

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 733, С. 150706 - 150706

Опубликована: Сен. 15, 2024

Язык: Английский