Identification of Clinical Value and Biological Effects of TTN Mutation in Hepatocellular Carcinoma DOI Creative Commons

Zhixue Zhang,

Yating Sun, Zhirui Zeng

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Abstract Hepatocellular carcinoma (HCC) is a malignant tumor of the digestive system and one leading causes cancer mortality worldwide. So far, various genetic mutations have been observed in hepatocellular related with tumorigenesis due to genomic instability. However, clinical characteristic therapeutic value HCC were extent unknown. In present study, by analyzing gene mutation landscape tissues from TCGA database, we demonstrated that TTN (titin) was high-frequency HCC, relevant poor prognosis HCC. had no relationship immune signature but linked change drug sensitivity GSK1904529A, nilotinib, 5-Fluorouracil (5-FU) sapitinib. Furthermore, through performing TIDE algorithm, CCK-8 assays, colony formation cell sphere-forming experiment, vivo transplantation experiment biological experiments investigated association between sensitivity. We found led increased stability protein, which depletion results decrease intracellular ferrous ion content, inhibiting ferroptosis pathway, significantly reduced 5-FU vitro vivo. These findings cause reduce 5-FU, reducing treatment efficacy. conclusion, our studies provided initial evidences can sever as biomarker for predicting prognosis, signature, molecular targets therapy It provides new idea solving resistance response treatment. Background: Methods: database Results: The research identified And leads decreasing levels, pathway. Conclusions: high frequency genes promotes protein stability, demonstrate weaken providing target address therapy.

Язык: Английский

lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer DOI Creative Commons
Asif Ahmad Bhat, Muhammad Afzal, Ehssan Moglad

и другие.

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Язык: Английский

Процитировано

9
Knocking Down Ferredoxin 1 Inhibits the Progression of Colorectal Cancer and Regulates Cuproptosis via Mediating the Hippo Signaling Pathway DOI Open Access
Ying Hu, Haihua Liu,

Xiaobin Tan

и другие.

Molecular Carcinogenesis, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

ABSTRACT Cuproptosis is a form of programmed cell death dependent on mitochondrial respiration and crucial in cancer treatment. The study attempted to screen cuproptosis‐associated genes colorectal (CRC) reveal regulatory pathways. Weighted gene co‐expression network analysis (WGCNA) was applied the modules based expression CRC patients. were screened at intersection cuproptosis data set. RNA sequencing performed assess transcriptome changes, followed by functional enrichment analyses potential Ferredoxin 1 (FDX1) knocked down vivo vitro experiments investigate effects FDX1 knockdown progression cuproptosis. found as highly expressed tumor cells. Knockdown regulated cells, inhibited growth, migration invasion. We 1956 upregulated DEGs 2201 downregulated si‐FDX1 which mainly enriched mitogen‐activated protein kinase (MAPK) signaling pathway, necrosis factor (TNF) pathway Hippo pathway. increasing levels dihydrolipoamide S‐succinyltransferase (DLST), lipoic acid synthetase (LIAS) phosphorylation Yes‐associated (pYAP)/YAP, transcriptional coactivator with PDZ‐binding domain (TAZ). inhibitor GA‐017 blocked this process. Knocking mediating shed new insights into development biomarkers for

Язык: Английский

Процитировано

1
Malondialdehyde and heavy metal contents in Piper betel: Possible risks of heavy metals in human health DOI
Md Muzammel Hossain,

Sunjida Jahan Tripty,

Md Zaki Azam Shishir

и другие.

Journal of Food Composition and Analysis, Год журнала: 2024, Номер 134, С. 106540 - 106540

Опубликована: Июль 14, 2024

Язык: Английский

Процитировано

6
Multifunctional Copper (I) Oxide Nanoparticles: Photocatalytic Degradation of Tetracycline, Antibacterial, and Anticancer Activities DOI
Soumen Rakshit,

Tamanna Roy,

Angshuman Jana

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(4)

Опубликована: Янв. 1, 2025

Abstract The increasing use of metal oxide nanoparticles demands a better understanding their health impact. Here, we report the synthesis copper (I) (Cu 2 O NPs) using cost‐effective chemical methods and assessed photocatalytic, antibacterial, anticancer properties. X‐ray diffraction (XRD) pattern verified its cubic structure. average crystallite size 11 nm was obtained Scherrer method. Fourier transform infrared (FTIR) spectroscopy confirmed formation Cu NPs. spherical morphology through field emission scanning electron microscopy (FESEM) analysis. High‐resolution transmission (HRTEM) estimated to be around 15 nm. photoelectron (XPS) spectra NPs showed peaks at 931.75 951.82 eV, corresponding 2p 3/2 1/2 , respectively. UV–vis revealed optical direct bandgap (2.33 eV) Under light irradiation, catalyst achieved tetracycline (TC) degradation efficiency 80% within 75 min. antibacterial properties against Klebsiella pneumoniae Bacillus subtilis agar disk diffusion have been investigated. also exhibited significant activity MCF‐7 cancer cells MTT assay, with an IC 50 value 18.88 µg/mL.

Язык: Английский

Процитировано

0
Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy DOI

Jingjing Jiang,

Shengnan Hu, Kaibo Hu

и другие.

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Язык: Английский

Процитировано

0
Investigating cuproptosis and mitochondrial dysfunction in brain cells: uncovering novel mechanisms and biomarkers for Parkinson’s disease DOI

Q. Li,

Dongliang Li, Yinghong Li

и другие.

Metabolic Brain Disease, Год журнала: 2025, Номер 40(3)

Опубликована: Март 12, 2025

Язык: Английский

Процитировано

0
Cell Death Mechanisms Produced by Carbon‐Based Nanoparticles DOI Creative Commons
Santos-Adriana Martel-Estrada, Claudia Vargas-Requena,

Josue-Itan Sifuentes-Chavarría

и другие.

Journal of Nanotechnology, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Using carbon‐based nanoparticles, such as diamond, graphite, fullerene, and nanotubes, has increased their research possible strategies for drug delivery to control diseases, especially cancer. However, because these materials, when interacting with the living environment, release substances that are capable of inducing cell death by themselves, it is vital importance analyze type particle can induce. Although there different efforts describe kind nanoparticles used treat diseases cancer, no paper explains mechanisms induced nanoparticle systems. Therefore, this attempts gain cutting‐edge information on using nanopolymorphisms mechanism particles produce. In conclusion, carbon interact directly membranes, causing physical damage disturbing integrity membrane. This alteration mainly lead necrosis or apoptosis. The definition a predominant each depends dose‐dependent manner. Primarily, concentrations cytotoxicity were 100–500 μg/mL. several studies analyzed, was only find nanodiamonds proved not be cytotoxic.

Язык: Английский

Процитировано

0
Combining network pharmacology and experimental validation to investigate the role of preserved egg white in intervening in chronic atrophic gastritis DOI Creative Commons

Jingying Sun,

Yulin Wang,

Yuanyuan Zhang

и другие.

Food, Nutrition and Health., Год журнала: 2025, Номер 2(1)

Опубликована: Апрель 14, 2025

Abstract Chronic atrophic gastritis (CAG) is regarded as a transitional stage in the progression from to gastric tumors. Although preserved egg white (PEW) recognized for its anti-inflammatory properties, precise impact and mechanisms treating inflammation are not fully understood. This study employed an integrative approach, combining network pharmacology with experimental validation, elucidate therapeutic effects of PEW on CAG underlying mechanisms. Through pharmacology, potential targets associated signaling pathways were identified. The results indicated that peptides within involved intervention alongside 61 targets. KEGG enrichment analysis unveiled 99 pathways. Molecular docking revealed favorable binding properties between PEW’s main active compounds core model was established using N-Methyl-N´-nitro-N-nitrosoguanidine (MNNG) comprehensive method. Cellular experiments demonstrated significant reduction secretion IL-6 (41.73%), IL-8 (20.35%), TNF-α (31.49%)， while enhancing cell proliferation motility ( P < 0.05). Animal showed alignment rat tissue glands, increased pepsin activity, reduced inflammatory factors serum, regulation Bcl-2 NF-κB expression following treatment. These findings collectively highlight CAG, presenting promising alternative treatment approach.

Язык: Английский

Процитировано

0
Identification of Clinical Value and Biological Effects of TTN Mutation in Hepatocellular Carcinoma DOI Creative Commons

Zhixue Zhang,

Yating Sun, Zhirui Zeng

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Abstract Hepatocellular carcinoma (HCC) is a malignant tumor of the digestive system and one leading causes cancer mortality worldwide. So far, various genetic mutations have been observed in hepatocellular related with tumorigenesis due to genomic instability. However, clinical characteristic therapeutic value HCC were extent unknown. In present study, by analyzing gene mutation landscape tissues from TCGA database, we demonstrated that TTN (titin) was high-frequency HCC, relevant poor prognosis HCC. had no relationship immune signature but linked change drug sensitivity GSK1904529A, nilotinib, 5-Fluorouracil (5-FU) sapitinib. Furthermore, through performing TIDE algorithm, CCK-8 assays, colony formation cell sphere-forming experiment, vivo transplantation experiment biological experiments investigated association between sensitivity. We found led increased stability protein, which depletion results decrease intracellular ferrous ion content, inhibiting ferroptosis pathway, significantly reduced 5-FU vitro vivo. These findings cause reduce 5-FU, reducing treatment efficacy. conclusion, our studies provided initial evidences can sever as biomarker for predicting prognosis, signature, molecular targets therapy It provides new idea solving resistance response treatment. Background: Methods: database Results: The research identified And leads decreasing levels, pathway. Conclusions: high frequency genes promotes protein stability, demonstrate weaken providing target address therapy.

Язык: Английский

Процитировано

0