Cellular Physiology and Biochemistry, Год журнала: 2025, Номер 59(S1), С. 1 - 24
Опубликована: Янв. 3, 2025
Thiazide, thiazide-like, and loop diuretics are primarily known for inhibiting members of the SLC12A family Cl– transporters, which include Na+Cl– cotransporter (NCC), Na+K+2Cl– cotransporters (NKCC1 NKCC2) K+Cl– symporters (KCC1-4). While main pharmacological effect these is diuresis, achieved by promoting excretion excess water salt through kidneys, they have intriguing effects beyond their traditional ones cannot be solely attributed to on renal transport. Of particular interest role in modulating inflammatory processes. These appear exert both pro- anti-inflammatory effects, potentially influencing various pathways involved immune responses. For example, NKCC1 has been implicated regulation pro-inflammatory cytokines, such as interleukin-1β (IL1β), interleukin-8 (IL8) tumor necrosis factor α (TNFα), critical mediators cell activity during inflammation. The underlying mechanisms contributes inflammation may involve key signaling pathways, that mediated nuclear kappa B (NFκB). This pathway crucial activation assembly inflammasome, well regulating phagocytic cells. In addition, can control (or controlled by) reactive oxygen species oxidative stress, contribute pathogenesis conditions well. Diuretics help mitigate inflammation-related tissue damage scavenging boosting antioxidant defenses, thereby restoring redox balance inflamed tissues. Despite precise molecular thiazide, thiazide-like modulate responses remain poorly understood warrant further investigation. aspect profile highlights potential therapeutic use scope diuretic functions.
Язык: Английский