Redefining Hepatocellular Carcinoma Treatment: Nanotechnology Meets Tumor Immune Microenvironment DOI
Chen Mi, Sai Liu, Zhida Chen

и другие.

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 47

Опубликована: Март 13, 2025

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, characterized by its complex pathogenesis and poor therapeutic outcomes. Despite recent advances in targeted molecular therapies, immune checkpoint inhibitors (ICIs), radiotherapy, conventional chemotherapy, five-year survival rate for this neoplasm remains dismally low. The progress nanotechnology has revolutionized cancer treatment years. These provide unprecedented opportunities to overcome current limitations different modalities. This review provides a comprehensive analysis how interfaces with tumor microenvironment (TIME) HCC can present new frontier interventions HCC. We critically overview latest developments nanoparticle-based delivery systems various drugs also other antitumor agents like thermal therapy radiotherapy. highlight unique ability nanoparticles modulate immunosuppressive (TME) enhance efficacy. Furthermore, we analyze emerging strategies that exploit nanoformulations biological barriers drug bioavailability treatment.

Язык: Английский

Resveratrol and capsaicin as safer radiosensitizers for colorectal cancer compared to 5-fluorouracil DOI Open Access
Samuel Amintas, Charles Dupin, Marie‐Alix Derieppe

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 183, С. 117799 - 117799

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

0
Iron Oxide Nanoparticles as Enhancers for Radiotherapy of Tumors DOI
Maria V. Shestovskaya, Anna L. Luss, Bezborodova Si

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

This research aimed to evaluate the potency of preparation based on heparinized iron oxide nanoparticles (hIONPs) in combination with radiation therapy, including magnetic delivery via applied field (AMF), sarcoma and cervical cancer models. For vitro studies, cells rhabdomyosarcoma (RD), fibrosarcoma (HT1080), (HeLa S3) were treated hIONPs analyzed for survival rate hIONP uptake. Then, cell morphology, cycle, increase reactive oxygen species, mitochondria depolarization, ability form colonies assessed combined treatment (hIONPs + 3Gy). vivo research, administered once hybrids CBAxC57Bl/6j mice, grafted (S37) (CC5) strains. The ultimate modes were: (1) i.v. (14 μg/kg) 5 Gy; (2) AMF (3) i.t. (2,8 Gy. overall rates, life expectancy, inhibition tumor growth (tumor inhibition), degree (T/C) determined, pathomorphological changes experimental groups. 3Gy) promotes multiple death high-severity peroxide effects compared other more sensitive than cells. vivo, an enhancing effect was revealed by radiotherapy magnetic-delivered hIONPs. S37 tumor, regimen characterized as having a high antitumor effect, ≪++++ ≫, 20% cure mice. CC5 accompanied growth, expectancy animals, significant ≪+++/++ ≫. From data obtained, it can be concluded that radiosensitizing potential may taken basis protocols.

Язык: Английский

Процитировано

0
Redefining Hepatocellular Carcinoma Treatment: Nanotechnology Meets Tumor Immune Microenvironment DOI
Chen Mi, Sai Liu, Zhida Chen

и другие.

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 47

Опубликована: Март 13, 2025

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, characterized by its complex pathogenesis and poor therapeutic outcomes. Despite recent advances in targeted molecular therapies, immune checkpoint inhibitors (ICIs), radiotherapy, conventional chemotherapy, five-year survival rate for this neoplasm remains dismally low. The progress nanotechnology has revolutionized cancer treatment years. These provide unprecedented opportunities to overcome current limitations different modalities. This review provides a comprehensive analysis how interfaces with tumor microenvironment (TIME) HCC can present new frontier interventions HCC. We critically overview latest developments nanoparticle-based delivery systems various drugs also other antitumor agents like thermal therapy radiotherapy. highlight unique ability nanoparticles modulate immunosuppressive (TME) enhance efficacy. Furthermore, we analyze emerging strategies that exploit nanoformulations biological barriers drug bioavailability treatment.

Язык: Английский

Процитировано

0