Опубликована: Янв. 1, 2024
Язык: Английский
Journal of the American Nutrition Association, Год журнала: 2025, Номер unknown, С. 1 - 17
Опубликована: Фев. 12, 2025
Objective Chronic liver diseases are accountable for approximately 2 million deaths annually. The current study aimed to test the putative prophylactic role of Kalanchoe pinnata against hepatic stress.
Язык: Английский
Процитировано
0
Natural Product Communications, Год журнала: 2025, Номер 20(3)
Опубликована: Март 1, 2025
Diabetes mellitus is a long-term metabolic condition marked by chronically high levels of glucose in the blood due to insufficient synthesis insulin or impaired function. Throughout history, several civilizations have used traditional medicinal plants treat and control diabetes. This paper offers thorough review, date, antidiabetic natural compounds origin, specifically highlighting their reported modes mechanisms action therapeutic possibilities, with view fast-tracking possibility transition pharmaceutical products for human use. Phytochemicals such as flavonoids, alkaloids, terpenoids, glycosides notable effects. They been shown via many processes, including boosting secretion, improving sensitivity, blocking absorption \gastrointestinal-tract, regulating carbohydrate metabolism. Unlike earlier reviews, this current one, addition chemistry proposed action, also x-rays effectiveness safety these chemicals combining evidences from laboratory research, animal experiments, clinical trials. Several substances, Demethoxycurcumin, Trigonelline, Ginsenosides, progressed trials, while others like Allicin Polypeptide-p at bedside. Bisdemethoxycurcumin, Vicine, Gymnemosides, are now preclinical trial phase, suggesting that research still ongoing there promise future application. The review highlights evolution diabetes management, potential improve treatment. It suggests incorporating plant-derived into treatments, reducing dependence on drugs adverse
Язык: Английский
Процитировано
0
Arabian Journal of Chemistry, Год журнала: 2025, Номер 0, С. 1 - 16
Опубликована: Март 31, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(8), С. 1299 - 1299
Опубликована: Апрель 8, 2025
Astragalus membranaceus, a plant that has been utilized in traditional Chinese medicine for centuries, is widely regarded as one of the most valuable herbs this medicinal tradition. It commonly referred to “yellow leader”, designation stems from yellow hue its significant organ, root, and adaptogenic properties. The renowned abundance active components, including polysaccharides, flavonoids, saponins, an array trace elements. demonstrated administration can prevent cellular aging, owing diverse range actions provide protection body both external internal factors. antioxidant, immunomodulatory, anti-inflammatory, regenerative properties contribute maintenance good skin condition, preventing atrophy subcutaneous tissue degeneration facial bones. Systemic encompass function cardiovascular, nervous, respiratory, digestive, excretory, immune, endocrine systems. This article reviews composition membranaceus beneficial effects root extract substances on whole body, with particular focus anti-aging skin.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3867 - 3867
Опубликована: Апрель 19, 2025
Medicinal plants, recognized as significant natural resources, have gained prominence in response to the increasing global demand for herbal medicines, necessitating large-scale production of these plants and their derivatives. are exposed a variety internal external factors that interact influence biosynthesis accumulation secondary metabolites. With rapid development omics technologies such genomics, transcriptomics, proteomics, metabolomics, multi-omics become important tools revealing complexity functionality organisms. They conducive further uncovering biological activities metabolites medicinal clarifying molecular mechanisms underlying Also, artificial intelligence (AI) technology accelerates comprehensive utilization high-dimensional datasets offers transformative potential analysis. However, there is currently no systematic review summarizing genomic metabolite plants. Safflower (Carthamus tinctorius L.) has rich diverse bioactive flavonoids, among which Hydroxysafflor yellow A (HSYA) specific safflower emerging medication treating wide range diseases. Hence, progress been made study an excellent example regulation recent years. Here, we on understanding main at level, summarize various types contents, with particular focus flavonoids. This aims provide insight into regulatory from perspective genomics.
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(9), С. 1913 - 1913
Опубликована: Апрель 25, 2025
Liver diseases, including chronic inflammation and related metabolic dysfunction-associated steatotic liver disease (MASLD), fibrosis cirrhosis remain a growing global health burden. Currently, available pharmacotherapy for dysfunction has limited efficacy. Kaempferol, naturally occurring flavonoid, demonstrated significant hepatoprotective effects in preclinical models. This substance activates the SIRT1/AMPK signalling pathway, improves mitochondrial function, inhibits proinflammatory cytokine production via TLR4/NF-κB suppression attenuates hepatic stellate cell activation by modulating TGF-β/Smad pathway. In addition, kaempferol regulates composition of gut microbiota, thus improving bile acid metabolism alleviating steatosis fibrosis. review presents an integrated analysis recent vitro vivo studies on mode action utility hepatoprotection.
Язык: Английский
Процитировано
0
Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 10421 - 10440
Опубликована: Дек. 1, 2024
Despite advancements in cancer treatment through surgery and drugs, hepatocellular carcinoma (HCC) remains a significant challenge, as reflected by its low survival rates. The mammalian target of rapamycin (mTOR) signaling pathway plays crucial role regulating the cell cycle, proliferation, apoptosis, metabolism. Notably, dysregulation leading to activation mTOR is common HCC, making it key focus for in-depth research current therapeutic strategies. This review focuses on downstream effectors HCC autophagy, metabolic reprogramming. Moreover, emphasizes potential natural products modulators pathway. When incorporated into combination therapies, these have been demonstrated augment efficacy surmount drug resistance. These pathways such pathways. Examples include 11-epi-sinulariolide acetate, matrine, asparagus polysaccharide. Their inhibitory effects processes suggest valuable directions development more effective Various ability inhibit suppress progression. phytochemicals, functioning inhibitors, hold great promise anti-HCC agents, especially context overcoming chemoresistance enhancing outcomes therapies.
Язык: Английский
Процитировано
2
Phytomedicine Plus, Год журнала: 2024, Номер unknown, С. 100638 - 100638
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1
Current Nutrition Reports, Год журнала: 2024, Номер unknown
Опубликована: Сен. 20, 2024
Язык: Английский
Процитировано
1
Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown
Опубликована: Окт. 5, 2024
Язык: Английский
Процитировано
1